ABO Objectives questions with correct answers

Name the scientist who first described the ABO blood group - Answer Karl Landsteiner State the importance of the ABO blood group in transfusion medicine - Answer Most important system in transfusion. Only system with expected naturally occurring antibodies for antigens not present on the RBCs Describe the genetics of the formation of RBC antigens as it applies to the ABO(H) system - Answer Inherit ABO gene from each parent and it expresses co-dominant expression State the location of the gene where the alleles are located for the production the ABO(H) antigens - Answer Allele results from gene interaction at 3 loci List the other genes which controls the occurrence and location of ABO antigens besides ABO - Answer ABO, Hh, Sese genes control occurrence/location of A and B antigens List the class of enzymes of the precursor for the RBC antigens - Answer glycosyltransferases carbohydrate or oligosaccharide chains of type 2 precursor substance found on surface of RBCs - Answer paragloboside Describe how information from the gene is synthesized and finally expressed by the antigens - Answer ABO locus alleles produce transferases that differ from one another in their ability to convert H antigen. Genes