Psychopathology and Psychopharmacology Raboud Lecture 2

Psychopharmacology
& Psychopathology
SOW-PSB3BC16E


Part 1: Principles of psychopharmacology
Lecture 2: Modes of communication


Hanneke den Ouden

, Neurons use chemicals to communicate
the ones we give




,g÷ É÷¥±
""""

Behavioral systems


Circuits


Neurons


]
these are the main
excitatory and
Mono-aminen
Synapses mono amine
-



inhibitory neuro
-




transmitters



Molecules Amino acids
↓
3
they are mini blocks
OF protein

, Amino acid neurotransmitters: Excitation and inhibition:
Very similar molecules, opposite effects!
-




↓
GABA
C
more -

inhibition
> if it binds to a neuron,
it is
going to depress
action potential in that

↑
neuron and make it Less Very
likely that the neuron is similar
going to fire an action ''
in structure
potential .
+

↓
Glutamate more +
excitation
↳ more likely

4
↳ either an action
is released
potential
or not .

, Glutamate: excitation

Acts at virtually all neurons in the brain
a) Cortico - brainstem
b) Cortico - striatal
c) Thalamo - cortical
d) Cortico - thalamic
e) Cortico - cortical




→
Glutamate
everywhere
is .



→
5 Glutamate pathways are the motorways of
the brain → .
where info travels
.