ATI Pharmacology Common Drugs Table

Heart - failure Digoxin (cardiac glycoside, used to treat dysrhythmias and heart failure) ● Therapeutic Levels 0.5-0.8 (Pg. 177) ● IV digoxin: infuse over AT LEAST 5min. ● WITHHOLD if HR LESS THAN 60/min ○ MUST auscultate apical pulse for one full minute ● Toxicity: Yellowing vision, blurry vision, anorexia, fatigue, weakness, N/V, GI effects, tinnitus, ● Narrow therapeutic range ● Positive inotrope (Increase force and efficiency of myocardial contraction), negative chronotrope (Decrease Heart rate) ● Hypokalemia leads to toxicity, hyper K leads to decreased effect ● Treatment is cholestyramine or Digibind ● To prevent “Digoxin-induced dysrhythmias, avoid hypokalemia and increased serum digoxin levels ○ Watch for n/v and general weakness. (hypokalemic) and caution with potassium supplements. ● Avoid any drug that affect potassium (loop diuretics, ACE Inh and ARBs)