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Samenvatting overzicht interleukines, chemokines, cytokines...

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Overzicht van alle te kennen interleukines, chemokines, cytokines, CD's, interferonen en hun werking. In het rood staat door wat ze geproduceerd worden.

Institution
Universiteit Gent (UGent)
Course
Infectie En Afweer








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Institution
Universiteit Gent (UGent)
Study
Geneeskunde
Course
Infectie En Afweer
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Document information

Uploaded on
February 26, 2023
Number of pages
3
Written in
2022/2023
Type
Summary

Subjects

  • infectie en afweer
  • immunologie
  • bruno verhasselt
  • bart vandekerckhove
  • microbiologie
  • 3e bachelor eerste semester

Content preview

INTERLEUKINES
IL-1 - Permeabiliteit bv ↗
- Prod acute fase eiw
Macrofagen, endogene pyrogenen - Koorts
IL-2 - Prolif + diff CD8 T-cellen
-  geheugen T-cellen
Th1 - Treg
IL-4 - Fibrose
- M2 macrofaag
- Th2
- Stim IgE
Baso/eosinofielen, NKT, Th2,TEM -  parasieten
IL-6 - Metabolisatie vet + spieren : T↗
- Prod acute fase eiw
- Prod hepcidine
- Koorts
- Th17 + Tfh
DC, macrofagen, endogene pyrogenen - Myeloïde diff HSC
IL-7 - Vorming + in stand houding T-cellen
(α,β,γ herschikkingen)
- Homeostatische expansie T-cellen
IL-8 = CXCL8 - Chemo-attractant: rekrutering
neutrofielen
IL-10 - Anti-inflammatoir
Th2, Treg - M2 macrofaag
IL-12 - Activ NK
- Th1 diff
DC, Th17 - Stim macrofagen
IL-15 - NK vorming
- Overleving geheugen T-cellen
IL-17 - Rekrutering neutrofielen
Th17
IL-21 - Tfh
- GF B-cellen (kiemcentrum)
IL-22 - Prod defensines
Th17 - Epitheliale barrière
IL-23 - Th17
DC


CHEMOKINES
CCL2 = MCP-1 - Activ + attr monocyten
CXCL8 = IL-8 - Rekrutering neutrofielen
CXCL13 - B-cellen naar prim follikel
CCL19 - Attr lymfocyten + DC naar LN
CCL21 - B-cellen naar LN
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