Chemotherapy/Immunotherapy Certificate Course (ONS, ONCC)verified 2023

Chemotherapy/Immunotherapy Certificate Course (ONS, ONCC)verified 2023Alkylating agents Classification Break DNA helix strand, thereby interfering with DNA replication Altretamine (Hexalen) Alkylating Agent PO Ovarian CA Side effects- nausea, vomiting, skin rash, hypersensitivity reaction, diarrhea Dose limiting - neuro-toxicity, peripheral neuropathy, myelosuppression Bendamustine (Treanda/Bendeka) Alkylating agent IV CLL or Indolent NHL Side effects- pyrexia, nausea, vomiting, skin reactions, TLS, hepatotoxicity, vein irritation Dose limiting - myelosuppression Irritant and vesicant properties infusion reactions likely to occur in 2nd or subsequent infusions Busulfan (IV busulfex: PO Myleran) Alkylating Agent IV or PO CML and Stem cell prep Side effects - profound tachycardia, HTN, chest pain, hyperpigmentation, alopecia, infertility, confusion, suizures, mucositis, nausea, vomiting, insomnia, hyperglycemia, blurred vision, secondary malignancy, VOD (now sinusoidal obstruction syndrome) seizure prophylaxis central line only for IV Carboplatin Alkylating agent IV Ovarian CA Side effects - neutropenia, nausea, vomiting, hypersensitivity, mild alopecia, skin rash Dose Limiting - thrombocytopenia Irritant AUC dosing Chlorambucil (Leukeran) Alkylating agent PO CLL, HL, NHL Side effects - infertility, nausea, vomiting, secondary malignancy, hyperuricemia, pulmonary fibrosis, seizure Dose Limiting - myelosuppression, skin reactions empty stomach caution in pts with seisure history and within 1 month of radiation or other cytotoxic therapy