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Samenvatting Overzichten Gezonde & zieke cellen 1 (GZC1)

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Universiteit Utrecht (UU)
Course
Gezonde en zieke cellen I









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Institution
Universiteit Utrecht (UU)
Study
Geneeskunde
Course
Gezonde en zieke cellen I
All documents for this subject (49)

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Uploaded on
February 13, 2023
Number of pages
6
Written in
2021/2022
Type
Summary

Subjects

  • gezonde
  • zieke
  • cellen
  • celbiologie

Content preview

Overzichten GZC 1
Naomi Janssen

Tumorsuppressor of oncogen
Tumorsuppressor Oncogen
PTEN* PI3-kinase
Rb-eiwit Ras-eiwit
P53 gen C-kit eiwit**
NF1 B-catenine
P21
APC
*PIP3 altijd actief  Bcl2 altijd actief  celdood niet geremd ongeremde celdeling
** receptor tyrosine kinase waar Gleevec (CML) effect op heeft

Celcyclus
Interfase
- G1-fase: celgroei en eiwitsynthese
- S-fase: DNA-replicatie
- G2-fase: celgroei en verdubbeling organellen
M-fase
- Profase: chromatine gecondenseerd tot chromosomen
- Prometafase: centrosomen maken connectie met chromosomen
- Metafase: chromosomen gaan naar midden van cel
- Anafase: zusterchromosomen uit elkaar getrokken (door microfibrillen)
- Telofase: duidelijke structuur DNA verdwijnt




*geel gemarkeerd is interfase

Cyclines
- Cycline D G1

, - Cycline E G1S
- Cycline A S & G2
- Cycline B G2 M & M




Uitzonderingen naamgeving tumoren




Carcinoma in situ = alleen in epitheel

Mesenchymaal




Epitheel
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