Gastric cancer Lecture 25
Basics
1. Second most common cancer
2. Dramatic decline worldwide
3. Wide variation in incidence
4. Altered risk among migrants
5. Male-to-female ratio: 1.5 to 2.0
6. Median age: 70 in USA
• Incidence: 7/100.000 inhabitants
• 5-yr survival rate of gastric carcinoma is 12% overall
• 5-yr survival for early gastric cancers(usually detected incidentally with endoscopy in
populationwhere screening is recommended) is >35%
Alcohol Use and Gastric Cancer: Generally, no association between alcohol use and
gastric cancer, Exceptionally, increased risk in relation to a heavy use of red wine and
vodka drinking
Helicobacter pylori and Gastric Cancer: current interpretation
• A definite cause of gastric cancer
• African enigma
• No sex difference in H. pylori
Dietary Factors and Gastric Cancer
Protective Factor
-Convincing: Vegetables and fruits, refrigerators
-Probable: Vitamin C -Possible: Carotenoids, allium compounds,wholegrain
cereals, green tea
1
, So, what are the risk factors?
Helicobacter pylori
Alimentary
Genetics (e-cadherine) – 10%
Smoking
Alcohol
Preneoplastic
• Atrofic gastritis
• Intestinal metaplasia
• Dysplasia
• Gastric polyps (adenomatous)
• Gastric resection – 5%
• Ménétrier gastritis
Dietary Factors and Gastric Cancer
Protective Factor
- Convincing: Vegetables and fruits, refrigerators
-Probable: Vitamin C
- Possible: Carotenoids, allium compounds, wholegrain cereals, green tea
Risk Factor
- Convincing: None
- Probable: Salt/salting
- Possible: Starch, grilled meat and fish
Clinical signs
1) Anemia
2) Astenie
3) Loss of weight
4) Abdominal pain
5) Hemorrhage
6) Dysphagia
2
Basics
1. Second most common cancer
2. Dramatic decline worldwide
3. Wide variation in incidence
4. Altered risk among migrants
5. Male-to-female ratio: 1.5 to 2.0
6. Median age: 70 in USA
• Incidence: 7/100.000 inhabitants
• 5-yr survival rate of gastric carcinoma is 12% overall
• 5-yr survival for early gastric cancers(usually detected incidentally with endoscopy in
populationwhere screening is recommended) is >35%
Alcohol Use and Gastric Cancer: Generally, no association between alcohol use and
gastric cancer, Exceptionally, increased risk in relation to a heavy use of red wine and
vodka drinking
Helicobacter pylori and Gastric Cancer: current interpretation
• A definite cause of gastric cancer
• African enigma
• No sex difference in H. pylori
Dietary Factors and Gastric Cancer
Protective Factor
-Convincing: Vegetables and fruits, refrigerators
-Probable: Vitamin C -Possible: Carotenoids, allium compounds,wholegrain
cereals, green tea
1
, So, what are the risk factors?
Helicobacter pylori
Alimentary
Genetics (e-cadherine) – 10%
Smoking
Alcohol
Preneoplastic
• Atrofic gastritis
• Intestinal metaplasia
• Dysplasia
• Gastric polyps (adenomatous)
• Gastric resection – 5%
• Ménétrier gastritis
Dietary Factors and Gastric Cancer
Protective Factor
- Convincing: Vegetables and fruits, refrigerators
-Probable: Vitamin C
- Possible: Carotenoids, allium compounds, wholegrain cereals, green tea
Risk Factor
- Convincing: None
- Probable: Salt/salting
- Possible: Starch, grilled meat and fish
Clinical signs
1) Anemia
2) Astenie
3) Loss of weight
4) Abdominal pain
5) Hemorrhage
6) Dysphagia
2
