2022
MAKING ASPIRIN
C: EXPLORE MANUFACTURING TECHNIQUES AND
TESTING METHODS FOR AN ORGANIC SOLID
BY: AJMAL SHEKEB NOORMAL
,Making Aspirin By: Ajmal Shekeb Noormal
Scenario
I work as a lab technician for a pharmaceutical company's research and development
division. Aspirin is one of the goods produced by the company. In order for the
business to effectively manufacture aspirin, I am looking into how to generate it and
assess its purity. I'll make some aspirin and examine its purity. I'll have to contrast
your laboratory procedure with the large-scale industrial aspirin manufacturing
process used by the pharmaceutical business.
Aspirin
Acetylsalicylic acid (ASA), popularly known as aspirin, is a drug used to treat
inflammation, fever, and pain. Kawasaki illness, pericarditis, and rheumatic fever are
a few specific inflammatory disorders that aspirin is used to treat. When taken soon
after a heart attack, aspirin reduces the risk of dying. Long-term usage of aspirin is
also used to help those at high risk avoid further heart attacks, ischemic strokes, and
blood clots. Effects usually start within 30 minutes for pain or fever. Aspirin is a non-
steroidal anti-inflammatory medication (NSAID) that functions similarly to other
NSAIDs while additionally inhibiting platelet function.1
Salicylic acid, a natural compound derived from myrtle, willow, and meadow sweet
and linked to synthetic aspirin, has been utilized in herbal therapy since ancient times
(at least 2500 BCE).
Aspirin's function has evolved throughout the course of its history from herbal folk
medicine to front-line pain reliever to prospective applications as a life-saving
preventive drug. Thousands of clinicians and scientists from around the world have
worked hard to produce all these advancements.
These groups are present in aspirin
Chemical formula = C9H8O4 or CH3COOC6H4COOH or HC9H7O4
Salicylic acid is converted into aspirin chemically through acetylation with acetic
anhydride. Aspirin has a molecular weight of 180.16 g/mol. It comes in colourless to
white crystals or crystalline powder and has no smell.2
Aspirin is a common pain reliever that can be used for a number of aches and pains,
including toothaches, period pains, and headaches. When used to treat a cold or the
flu, they are also helpful since they lower high temperatures. Other medications, such
as those prescribed for the common cold and the flu, may also contain aspirin. Your
doctor may advise you to take a low dose of aspirin twice daily in the event of a stroke,
heart attack, or danger of either.3
There are hormones called prostaglandins that are released when the body is injured
or infected. They may result in a fever and swelling, which alerts the brain to pain,
1
, Making Aspirin By: Ajmal Shekeb Noormal
the body's normal reaction to injury. Aspirin suppresses the production of
prostaglandins, which reduces pain intensity and the impact of swelling and fevers. 3
Practical; Preparation of Aspirin:
Aim:
In this experiment, we use ethanoic anhydride to convert 2-hydroxybenzoic acid into
aspirin, recrystallisation and to test its purity against pure substance.
Equipment:
2-hydroxybenzoic acid
Weighing scale
Pear shaped flask
Condenser
Ethanoic anhydride
Concentrated phosphoric acid
Fume cupboard
Water bath
Water
Glass rod
Buchner funnel
Suction apparatus
Watch glass
Test tubes
Pure aspirin
Phenol
Iron (|||) chloride
Capillary tube
Bunsen burner
Heatproof mat
Desiccator
Glycerol
Thermometer
Method for preparation of aspirin:
Although the product is generated as part of a combination with a number of other
chemicals, the reaction proceeds efficiently in an acidic solution. Stage 1 below
describes the formation of the product, and Stage 2 describes the separation of
2
MAKING ASPIRIN
C: EXPLORE MANUFACTURING TECHNIQUES AND
TESTING METHODS FOR AN ORGANIC SOLID
BY: AJMAL SHEKEB NOORMAL
,Making Aspirin By: Ajmal Shekeb Noormal
Scenario
I work as a lab technician for a pharmaceutical company's research and development
division. Aspirin is one of the goods produced by the company. In order for the
business to effectively manufacture aspirin, I am looking into how to generate it and
assess its purity. I'll make some aspirin and examine its purity. I'll have to contrast
your laboratory procedure with the large-scale industrial aspirin manufacturing
process used by the pharmaceutical business.
Aspirin
Acetylsalicylic acid (ASA), popularly known as aspirin, is a drug used to treat
inflammation, fever, and pain. Kawasaki illness, pericarditis, and rheumatic fever are
a few specific inflammatory disorders that aspirin is used to treat. When taken soon
after a heart attack, aspirin reduces the risk of dying. Long-term usage of aspirin is
also used to help those at high risk avoid further heart attacks, ischemic strokes, and
blood clots. Effects usually start within 30 minutes for pain or fever. Aspirin is a non-
steroidal anti-inflammatory medication (NSAID) that functions similarly to other
NSAIDs while additionally inhibiting platelet function.1
Salicylic acid, a natural compound derived from myrtle, willow, and meadow sweet
and linked to synthetic aspirin, has been utilized in herbal therapy since ancient times
(at least 2500 BCE).
Aspirin's function has evolved throughout the course of its history from herbal folk
medicine to front-line pain reliever to prospective applications as a life-saving
preventive drug. Thousands of clinicians and scientists from around the world have
worked hard to produce all these advancements.
These groups are present in aspirin
Chemical formula = C9H8O4 or CH3COOC6H4COOH or HC9H7O4
Salicylic acid is converted into aspirin chemically through acetylation with acetic
anhydride. Aspirin has a molecular weight of 180.16 g/mol. It comes in colourless to
white crystals or crystalline powder and has no smell.2
Aspirin is a common pain reliever that can be used for a number of aches and pains,
including toothaches, period pains, and headaches. When used to treat a cold or the
flu, they are also helpful since they lower high temperatures. Other medications, such
as those prescribed for the common cold and the flu, may also contain aspirin. Your
doctor may advise you to take a low dose of aspirin twice daily in the event of a stroke,
heart attack, or danger of either.3
There are hormones called prostaglandins that are released when the body is injured
or infected. They may result in a fever and swelling, which alerts the brain to pain,
1
, Making Aspirin By: Ajmal Shekeb Noormal
the body's normal reaction to injury. Aspirin suppresses the production of
prostaglandins, which reduces pain intensity and the impact of swelling and fevers. 3
Practical; Preparation of Aspirin:
Aim:
In this experiment, we use ethanoic anhydride to convert 2-hydroxybenzoic acid into
aspirin, recrystallisation and to test its purity against pure substance.
Equipment:
2-hydroxybenzoic acid
Weighing scale
Pear shaped flask
Condenser
Ethanoic anhydride
Concentrated phosphoric acid
Fume cupboard
Water bath
Water
Glass rod
Buchner funnel
Suction apparatus
Watch glass
Test tubes
Pure aspirin
Phenol
Iron (|||) chloride
Capillary tube
Bunsen burner
Heatproof mat
Desiccator
Glycerol
Thermometer
Method for preparation of aspirin:
Although the product is generated as part of a combination with a number of other
chemicals, the reaction proceeds efficiently in an acidic solution. Stage 1 below
describes the formation of the product, and Stage 2 describes the separation of
2
