Walden 6630 Psychopharmacology Midterm Study Guide Questions And Answers 2022/2023

Serotonin regulates - Answer - Mood, emotion, feeding, and reproductive behavior This class of antidepressants binds to presynaptic SERT and inhibits them from reuptake of serotonin to increase levels in the synaptic cleft to bind with postsysnaptic 5HT2 receptors - Answer - SSRIs First line therapy for MDD due to milder side effect profiles - Answer - SSRIs Six Common SSRIs - Answer - citalopram, escitalopram, fluoxetine, fluvoxamine, sertraline, paroxetine Onset of therapeutic benefit from SSRIs - Answer - 4-6 weeks In addition to MDD, SSRIs also treat - Answer - Chronic Anxiety, PTSD, OCD, and eating disorders (bulimia) Five Common side effects of SSRIs include - Answer - Anxiety, insomnia, GI distress, sexual dysfunction (ED), SIADH Severe side effect of SSRIs in children/adolescents under age 25 years old - Answer - suicidal ideation Life threatening adverse effect of SSRIs, especially when used in combination with other serotonergic drugs (SNRIs, TCAs, MAOIs, etc.) - Answer - Serotonin Syndrome Excess accumulation of serotonin resulting in overstimulation of the nervous system - Answer - Serotonin Syndrome Seven symptoms of Serotonin Syndrome - Answer - Flushing, hyperthermia, agitation, muscle rigidity, seizure, coma, HYPERreflexia The treatment for serotonin syndrome - Answer - Cyproheptadine (5-HT2 receptor antagonist) Cyproheptadine treats serotonin syndrome by - Answer - blocking 5-HT2 receptors (serotonin antagonist) When SSRIs or SNRIs are stopped abruptly, common symptoms of withdrawal include - Answer - Irritability, headaches, and insomnia Medicine specific side effect of citalopram - Answer - Prolonged QT interval (normal=0.4.-0.44 seconds) This SSRI is pregnancy category D due to associations with congenital heart defects - Answer - Paroxetine