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Chapter 04: Transport of Substances Through Cell Membranes
Hall: Guyton and Hall Textbook of Medical Physiology, 14th Edition
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MULTIPLE CHOICE
1. Which of the following correctly ranks the permeabilities of molecules for an artificial
lipid bilayer without any transporters or other protein structures in the membrane? a.
Nitrogen > Glucose > Sodium
b. Sodium > Glucose > Carbon dioxide
c. Urea > Oxygen > Water
d. Potassium > Ethanol > Water
e. Carbon dioxide > Glucose > Oxygen
ANS: A
2. Which of the following substances have a higher extracellular concentration compared to
the intracellular concentration? a. Sodium and chloride
b. Potassium and sodium
c. Calcium and potassium
d. Potassium and proteins
e. Chloride and potassium
ANS: A
3. Which of the following transport mechanisms requires a protein carrier?
a. Primary active transport and secondary active transport only
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b. Primary active transport only
c. Secondary active transport only
d. Primary active transport, secondary active transport, and facilitated diffusion
e. Facilitated diffusion only
ANS: D
4. A 43-year-old woman has serum potassium of 2.5 mEq/L (reference range: 3.5–5.0 mEq/L).
Which of the following sets of changes best describe the resting membrane potential (Vm) and
K+ Nernst potential (EK) in a typical neuron in this woman, compared to normal? (Assume
normal intracellular concentration of K+.) a. EK, less negative; Vm, less negative
b. EK, less negative; Vm, no change
c. EK, less negative; Vm, more negative
d. EK, more negative; Vm, less negative
e. EK, more negative; Vm, more negative
f. EK, more negative; Vm, no change
g. EK, no change; Vm, less negative
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h. EK, no change; Vm, more negative
ANS: E
5. A transmembrane gradient for which of the following ions is most likely to power secondary
active transport in the human body?
a. Calcium
b. Sodium
c. Potassium
d. Chloride
e. Magnesium
ANS: B
6. Which of the following best describes a reasonable clinical estimate of plasma osmolarity?
a. 2 plasma sodium concentration
b. 2 plasma potassium concentration
c. 1 plasma sodium concentration
d. 3 plasma potassium concentration
e. 2 plasma calcium concentration
f. 1 plasma chloride concentration ANS: A
7. An artificial membrane is created consisting of a lipid bilayer without protein molecules in the
membrane. The lipid composition of the membrane is the same as that of a normal, biological
membrane. Which of the following substances permeates the membrane more readily than
water molecules?
a. Carbon dioxide
b. Glucose
c. Glycerol G MRADESLAB.CO
d. Sodium
e. Urea ANS: A
8. A cell is equilibrated in an aqueous solution of 300 mOsm/L sodium chloride. Which of the
following best describes what will happen to cell volume when the cell is placed in an aqueous
solution of 300 mOsm/L calcium chloride? a. Decrease
b. Decrease and then increase
c. Increase
d. Increase and then decrease
e. No change ANS: E
9. The intracellular calcium ion concentration of ventricular muscle cells averages 10–4 mmol/L
during diastole. The calcium ion concentration in transverse tubules (T tubules) averages 2.5
mmol/L at rest. A protein transporter on the membrane of the T tubule exchanges sodium for
calcium. The transporter uses the transmembrane sodium gradient to fuel the exchange. Which
of the following transport mechanisms best describes this type of transporter? a. Facilitated
diffusion
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