Chapter 2: Review of Basic Principles of Pharmacology
Multiple Choice
Identify the choice that best completes the statement or answers the question.
__A__ 1. A patient’s nutritional intake and lab work reflects hypoalbuminemia.
This is critical to prescribing because:
A. Distribution of drugs to target
tissue may be affected
B. The solubility of the drug will not
match the site of absorption
C. There will be less free drug
available to generate an effect
D. Drugs bound to albumin are
readily excreted by the kidney
___C_ 2. Drugs that have a significant first-pass effect:
A. Must be given by the enteral
(oral) route only
B. Bypass the hepatic circulation
C. Are rapidly metabolized by the
liver and may have little if any
desired action
D. Are converted by the liver to
more active and fat-soluble forms
___B_ 3. The route of excretion of a volatile drug will likely be:
A. The kidneys
B. The lungs
C. The bile and feces
D. The skin
__C__ 4. Medroxyprogesterone (Depo Provera) is prescribed IM to create a
storage reservoir of the drug. Storage reservoirs:
A. Assure that the drug will reach its
intended target tissue
B. Are the reason for giving loading
doses
C. Increase the length of time a
drug is available and active
D. Are most common in collagen
tissues
__B__ 5. The NP chooses to give cephalexin every 8 hours based on knowledge
of the drug’s:
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https://www.coursehero.com/file/13633080/Ch02/
, A. Propensity to go to the target
receptor
B. Biological half-life
C. Pharmacodynamics
D. Safety and side effects
__A__ 6. Azithromycin dosing requires the first day’s dose be twice those of the
other 4 days of the prescription. This is considered a loading dose. A
loading dose:
A. Rapidly achieves drug levels in
the therapeutic range
B. Requires four to five half-lives to
attain
C. Is influenced by renal function
D. Is directly related to the drug
circulating to the target tissues
__C__ 7. The point in time on the drug concentration curve that indicates the
first sign of a therapeutic effect is the:
A. Minimum adverse effect level
B. Peak of action
C. Onset of action
D. Therapeutic range
__D__ 8. Phenytoin requires a trough level be drawn. Peak and trough levels are
done:
A. When the drug has a wide
therapeutic range
B. When the drug will be
administered for a short time
only
C. When there is a high correlation
between the dose and saturation
of receptor sites
D. To determine if a drug is in the
therapeutic range
___B_ 9. A laboratory result indicates the peak level for a drug is above the
minimum toxic concentration. This means that the:
A. Concentration will produce
therapeutic effects
B. Concentration will produce an
adverse response
C. Time between doses must be
shortened
This study source was downloaded by 100000827506713 from CourseHero.com on 08-06-2022 03:39:24 GMT -05:00
https://www.coursehero.com/file/13633080/Ch02/
Multiple Choice
Identify the choice that best completes the statement or answers the question.
__A__ 1. A patient’s nutritional intake and lab work reflects hypoalbuminemia.
This is critical to prescribing because:
A. Distribution of drugs to target
tissue may be affected
B. The solubility of the drug will not
match the site of absorption
C. There will be less free drug
available to generate an effect
D. Drugs bound to albumin are
readily excreted by the kidney
___C_ 2. Drugs that have a significant first-pass effect:
A. Must be given by the enteral
(oral) route only
B. Bypass the hepatic circulation
C. Are rapidly metabolized by the
liver and may have little if any
desired action
D. Are converted by the liver to
more active and fat-soluble forms
___B_ 3. The route of excretion of a volatile drug will likely be:
A. The kidneys
B. The lungs
C. The bile and feces
D. The skin
__C__ 4. Medroxyprogesterone (Depo Provera) is prescribed IM to create a
storage reservoir of the drug. Storage reservoirs:
A. Assure that the drug will reach its
intended target tissue
B. Are the reason for giving loading
doses
C. Increase the length of time a
drug is available and active
D. Are most common in collagen
tissues
__B__ 5. The NP chooses to give cephalexin every 8 hours based on knowledge
of the drug’s:
This study source was downloaded by 100000827506713 from CourseHero.com on 08-06-2022 03:39:24 GMT -05:00
https://www.coursehero.com/file/13633080/Ch02/
, A. Propensity to go to the target
receptor
B. Biological half-life
C. Pharmacodynamics
D. Safety and side effects
__A__ 6. Azithromycin dosing requires the first day’s dose be twice those of the
other 4 days of the prescription. This is considered a loading dose. A
loading dose:
A. Rapidly achieves drug levels in
the therapeutic range
B. Requires four to five half-lives to
attain
C. Is influenced by renal function
D. Is directly related to the drug
circulating to the target tissues
__C__ 7. The point in time on the drug concentration curve that indicates the
first sign of a therapeutic effect is the:
A. Minimum adverse effect level
B. Peak of action
C. Onset of action
D. Therapeutic range
__D__ 8. Phenytoin requires a trough level be drawn. Peak and trough levels are
done:
A. When the drug has a wide
therapeutic range
B. When the drug will be
administered for a short time
only
C. When there is a high correlation
between the dose and saturation
of receptor sites
D. To determine if a drug is in the
therapeutic range
___B_ 9. A laboratory result indicates the peak level for a drug is above the
minimum toxic concentration. This means that the:
A. Concentration will produce
therapeutic effects
B. Concentration will produce an
adverse response
C. Time between doses must be
shortened
This study source was downloaded by 100000827506713 from CourseHero.com on 08-06-2022 03:39:24 GMT -05:00
https://www.coursehero.com/file/13633080/Ch02/
