NR 566 Week 7 Study Guide Complete Solution/TOP SCORE

NR 566 Week 7 Study Guide Chapter 48: Women as Patients Pharmacokinetic gender differences between men and women  These three medications have shown differences that are clearly significant betw ee n men and women  Propranolol (Inderal): early drug that showed a clear gender difference in metabolism (clearance) o PO doses: significantly higher (63%) rate of clearance in men than women o IV doses do not do this: indicates hepatic first pass metabolism o Women: show a significantly greater clinical response to PO doses  Verapamil (Isoptin, Calan): PO clears more quickly in men than women based on CYP3A4 o Higher absolute bioavailability in women causes greater pharmacodynamic effects on BP and HR in women  Erythromycin: more effective in women o More rapidly cleared in women than men r/t CYP 3A4