VACCINEIMMUNOLOGY
Smallpox vaccines
I 796 inoculated an 8 old with fluid from
year boy
6
a cowpoxpustule weeks later
boy is exposed tosmallpox
No symptoms developed
How globaleradication was possible
Virus biology No animal resevoir
Lifelongimmunity
sub clinical cases rare
Infectivity does not precedesymptoms
One serotype
Good vaccine vaccinia virus
Global commitment
Er radicated in 1977
Rinderpest virus
Highly contagious virus of livestock
Up to 100 mortality
Caused Poverty t major economic losses
In 2011 it was officiallyeradicated
, Polio
Goals of vaccination against viruses
Induceimmunity that Prevents or limits viral disease
and causes no or limited associated morbidity1mortality
Induce herd immunity that Greatly reduces viral
circulation in agiven community and protects vulnerable
members of the community for whom the vaccine is proscribed
Virus eradication
Herd immunity vs
Smallpox vaccines
I 796 inoculated an 8 old with fluid from
year boy
6
a cowpoxpustule weeks later
boy is exposed tosmallpox
No symptoms developed
How globaleradication was possible
Virus biology No animal resevoir
Lifelongimmunity
sub clinical cases rare
Infectivity does not precedesymptoms
One serotype
Good vaccine vaccinia virus
Global commitment
Er radicated in 1977
Rinderpest virus
Highly contagious virus of livestock
Up to 100 mortality
Caused Poverty t major economic losses
In 2011 it was officiallyeradicated
, Polio
Goals of vaccination against viruses
Induceimmunity that Prevents or limits viral disease
and causes no or limited associated morbidity1mortality
Induce herd immunity that Greatly reduces viral
circulation in agiven community and protects vulnerable
members of the community for whom the vaccine is proscribed
Virus eradication
Herd immunity vs
