BETA BLOCKERS
Adreno ceptors distribution t function
Heart controls rate force of contraction 1 cardiac
BI TCO when
conductivity primarily affinity
stimulated Higher affinity for adrenaline
Blood vessels arteries veins constriction
Primarily L1
skeletal blood vessels dilation primarily 132
Nonvascular smooth muscle Cgenerally constricts with
1 and dilates with 132
dilates C132
Airways
Increased renin secretion BZ
kidney
Peripheral sympathetic nerves When 132 stimulated
Increased NE production
When L2 stimulated WWE secretion
Adreno ceptor antagonists Drugs which occupy adreno
Ceptors and prevent the action of adrenaline epinephrine
and noradrenaline norepinephrine
Includes Beta blockers C lol alpha 1 blockers Cosin
, Classification of B blockers
A Via pharma codynamicproperties selection
Not partial agonist non selective propanol or
Not partial
agonist t Bl selective ate nolo
Partial agonist t non selective Pin do lol
Partial agonist t B 1 selective a Cebu to lol
Drugs with additional actions e g Sota lol is also a
class III anti arrythmic activity t carved it or is an
arteriolar vasodilator
B Via pharmacokinetic properties metabolism
Water soluble Ate not or Sota lol little metabolism
less
mainly eliminated by the kidneys long half lives
frequentdosage close reduced in renal impairment
Less
likely to cross blood brain barrier so less sleep disturbance
Lipid soluble Propanolor oxpremotor Extensive
metabolism
long half lives frequent administration
more
close lowered in hepative impairment More likely to cross
blood brain barrier so more sleep disturbance
Adreno ceptors distribution t function
Heart controls rate force of contraction 1 cardiac
BI TCO when
conductivity primarily affinity
stimulated Higher affinity for adrenaline
Blood vessels arteries veins constriction
Primarily L1
skeletal blood vessels dilation primarily 132
Nonvascular smooth muscle Cgenerally constricts with
1 and dilates with 132
dilates C132
Airways
Increased renin secretion BZ
kidney
Peripheral sympathetic nerves When 132 stimulated
Increased NE production
When L2 stimulated WWE secretion
Adreno ceptor antagonists Drugs which occupy adreno
Ceptors and prevent the action of adrenaline epinephrine
and noradrenaline norepinephrine
Includes Beta blockers C lol alpha 1 blockers Cosin
, Classification of B blockers
A Via pharma codynamicproperties selection
Not partial agonist non selective propanol or
Not partial
agonist t Bl selective ate nolo
Partial agonist t non selective Pin do lol
Partial agonist t B 1 selective a Cebu to lol
Drugs with additional actions e g Sota lol is also a
class III anti arrythmic activity t carved it or is an
arteriolar vasodilator
B Via pharmacokinetic properties metabolism
Water soluble Ate not or Sota lol little metabolism
less
mainly eliminated by the kidneys long half lives
frequentdosage close reduced in renal impairment
Less
likely to cross blood brain barrier so less sleep disturbance
Lipid soluble Propanolor oxpremotor Extensive
metabolism
long half lives frequent administration
more
close lowered in hepative impairment More likely to cross
blood brain barrier so more sleep disturbance
