NURS 660 660_Exam3_painfulreview

What is the medication that is the antidote for alprazolam? (If someone ODs). a. In overdosed-administer Flumazenil (benzo antagonist)-Stahl-can reverse od or induce sz or withdrawal in pts dependent on benzos 2. What is the MOA of pregabalin that makes it alleviate pain for people with fibromyalgia or chronic fatigue? a. Gabapentin and Lyrica are analgesic adjuncts that bind to open conformation of VS calcium channels (prevent release of NTs including glutamate) in CNS tissue and stabilize neuronal membranes, thus interfering with the transmission of pain impulses rather than binding to opioid receptors b. “Fibro-Fog” – Dorsolateral pre frontal cortex and anterior thalamus. 3. Caffeine – what is an antagonist of caffeine? So caffeine promotes being awake and alert, and opposes the homeostatic drive. It’s an antagonist of what? a. Caffeine and theophylline can block adenosine effects-Caffeine antagonist is adenosine b. withhold caffeine for 5 half-lives prior to adenosine; avoid dietary caffeine for at least 12 hrs prior to pharm stress test c. The body will build up levels of adenosine due to caffeine using receptor sites.