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Summary Radiotherapy lecture 2 Period 2 (MIRT)

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December 6, 2021
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RT summary 1.2b


- ICRU = International commission on radiation units and measurements
- For Radiotherapy 2 important reports :
o ICRU 50 : Prescribing, recording and reporting photon beam therapy
o ICRU 62 (the update): Supplement to ICRU 50, which is still valid.

Context:

- Consult  CT  Treatment planning  treatment delivery  Patient’s final visit
o Consult: radiation oncologist
o CT: position the patient, add the external body markers
o Patient’s final visit: after this for the radiation oncologist, the follow up treatment
starts.

Treatment goals:

- Radical treatment of malignant (curative treatment)
o Achieve permanent tumor control
o Volumes to be treated: Tumor + expected sub-clinical disease
- Palliative treatment of malignant disease
o Decrease of symptoms
o May include all or only part of tumor (as long as we can guarantee the decrease of
the symptoms)

GTV (Gross tumor volume):

- Gross demonstrates extend and localization of malignant
growth. (the tumor itself)
o Consist of:
 Primary tumor
 Metastatic lymph nodes
 Distant metastasis

! note : if tumor has been removed prior to radiotherapy no GTV
can be find.

- Determination of GTV:
o Clinical:
 Inspection
 Palpation
 Endoscopy
o Imaging techniques:
 X-ray
 Ultrasound
 MRI
 PET-CT
o Reason to determine GTV:

,  Staging of tumor according to TNM classification
 Define area for dose delivery, we should know what to treat
 GTV can be used to assess treatment response during or after the treatment.

CTV (clinical target volume):

- The clinical target volume is the margin around the GTV
to include microscopic spread of disease.
o There is always the chance that there are
malignant cells on microscopic levels.
- This volume must be treated thoroughly in order to
achieve the aim of radical therapy.
o So when we perscribe a treatment dose for the
patient we perscribe it for the CTV.



PTV (planning target volume)

- PTV is one of the most important structures.
- Around the CTV we expand a margin, we need that
margin for geometric variations and uncertainties.
o All uncertainties during treatment planning:
 In the positions
 Sizes
 Shapes
 Delineation
o All uncertainties during treatment delivery:
 Physical uncertainties
 Setup errors during positioning
 Patient movement
 Physical changes in the patient

!! whatever happens we have to guarantee, that our tumor and the CTV is in the high dose area of
our treatment prescription.



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