Vernon Russel vSim.

Vernon Russel vSim/Vernon Russel vSim. Stoke is a syndrome of acute focal neurologic deficit from a vascular disorder that injures brain tissue. This can occur from, atherosclerosis, dissecting aneurysm, infectious vasculitis, syphilis, congenital defects, coronary artery spasm. The pathology process beings from increased blood levels of LDLs that can irritate or damage the inner layer of coronary vessels. The LDL enters the vessel after damaging the protective barrier, accumulates, and forms a fatty streak. Smooth muscle cells move to the inner layer to engulf the fatty substance, produce fibrous tissue, and stimulate calcium deposition. Eventually fatty streak transform into fibrous plaque and a coronary artery lesion develops. This lesion causes oxygen deprivation and forces the myocardium to do anaerobic metabolism instead of aerobic which leads to an accumulation of lactic acid and reduction of cellular pH. In hand, the combination of the hypoxia, reduced energy, and acidosis impairs the ventricular function, resulting in less blood being ejected from the heart with each contraction. These Plaques can rupture due to disruption of the fibrous cap, leading to acute events such as stroke. Risks factors include age, sex, race, prior stroke, family history, hypertension, smoking and in this patients case diabetes.