structure& function of amino acids and proteins

Notes Theiaminoiacidibalance Theicirculationiofiaminoiacidithroughoutithe iorgansiandicellsiofithe ihumanibody. iWeidivide iaminoiacid ibalanceiinto: • Systemiciaminoiacidibalance • Cellulariaminoiacidibalance Fromiaisystemicistandpoint, iwe'lliaddress… • Digestioniandiabsorptioniofitheiessentialiaminoiacidsiviaiprotein idigestioniandiabsorption. • Passageiviaitheiportaliveinitoitheiliver, iwhichiisitheimajoriorganithatimetabolizesiaminoiacidsiandimanages itheiriammonia iandicarbon iskeletons. • Passageiintoisystemiciarterialicirculationiintoikeyiextra–ihepaticiorgansi(eg, imuscleiandikidneys). Fromia icellularistandpoint, iwe'lliaddress… • Aminoiacidiuptakeiviaiaminoiacid–ispecificitransporters. • The iconcept iofithe iamino iacid ipool i– ithe ipool iofiamino iacidsiwithin ithe icytoplasm, iwhich idistributes itoiproteinsisynthesisiand ithe ibiosynthesisiofismall imolecules, iincluding ithe inucleic iacidsinecessaryifor itheiformation iofiDNAitranscription. systemiciaminoiacidibalance • Drawiaiheadiandineck, istomach, iproximalismalliintestine, iandipancreas. • Showithatidietaryiproteinientersiin iitsifoldedistate. • IndicateithatitheihighlyiacidicipHiofitheistomach i(~2)ifromitheiHCLidenaturesi(uncoils)itheiprotein. • Showithatiproteasesi(akaipeptidases), iwhich ioperateiiniaimoreineutralienvironmenti(pHi~6), ifromithe