Pathophysiology: Exam #1 Practice
Questions with verified answers
Tay-Sachs disease - ANSWER-Tay-Sachs disease
Which of the following follows a multifactorial pattern of inheritence?
Coronary artery disease
Down Syndrome
Marfan Syndrome
Tay-Sachs disease - ANSWER-Coronary artery disease
Fortification of foods with folic acid has resulted in a significant reduction in the
incidence of - ANSWER-neural tube defects
Which of the following chromosomal abnormalities can result in an inheritable form of
trisomy?
Nondisjunction during meiosis
Balanced translocation
Insertion
Deletion - ANSWER-Balanced translocation
Which type of hemoglobin is produced during sickle-cell crisis? - ANSWER-HbS
Mitochondrial gene disorders are transmitted to - ANSWER-both daughters and sons
Mitochondrial genes produce proteins involved in - ANSWER-energy metabolism
What is a manifestation of Down Syndrome? - ANSWER-Epicanthal eye folds
Which prenatal test(s) diagnose Down Syndrome? - ANSWER-Karyotype
What is the risk of a mother with the genetic mutation that causes Fragile-X
syndrome passing the gene on to an offspring? - ANSWER-50% of males affected
Which chromosomal abnormality is incompatible with life? - ANSWER-Monosomy 21
Affects females only - ANSWER-Turner syndrome
The target of damage in Huntington's Disease - ANSWER-nerve tissue
Maternal serum alpha-fetoprotein (MSAFP) is a screening test for which condition? -
ANSWER-Spina Bifida
A patient comes to the clinic concerned about a painless lymph node in the neck. A
diagnosis of lymphoma is made. Which of the following would indicate the lymphoma
was Hodgkin lymphoma?
The location of the enlarged lymph nodes
The presence of Reed-Sternberg cells
, Spread to the spleen, liver, and bone marrow
The age of the patient - ANSWER-The presence of Reed-Sternberg cells
Which of the following genes, when mutated, is NOT implicated in the development
of neoplasms?
Carcinogenesis
Tumor suppressor genes
Oncogenesis
Mutator genes - ANSWER-Cancinogenes
Which of the following cells is least likely to develop into a neoplasia?
p53 gene
Rb gene
T21 gene - ANSWER-p53 gene
Which of the following is a characteristic of benign neoplasms?
Highly undifferentiated
Invasive
Destructive
Cell Overproliferation - ANSWER-Cell overproliferation
What is the most significant difference between acute lymphocytic and acute
myelogenous leukemia? - ANSWER-Cell type affected
Your grandfather has colon cancer but then it migrated to the liver. The affinity for
movement to another specific organ is called - ANSWER-Tropism
You are a public health official and want to make the greatest difference in reducing
cancer deaths across the globe. Which intervention would have the greatest impact?
- ANSWER-Smoking cessation programs
What sign/symptom might indicate that you are experiencing a paraneoplastic
syndrome? - ANSWER-Edema
What type of cancer would most likely spread through the process called seeding? -
ANSWER-Ovarian
Which of the following is an example of a strong acid?
Albumin
Inorganic phosphorus
Sodium
Lactate - ANSWER-Lactate
Fluid loss in response to hypervolemia is promoted by - ANSWER-Inhibiting the
secretion of aldosterone, promoting urinary sodium and water elimination
What ion is most closely related to water movement? - ANSWER-Sodium
Questions with verified answers
Tay-Sachs disease - ANSWER-Tay-Sachs disease
Which of the following follows a multifactorial pattern of inheritence?
Coronary artery disease
Down Syndrome
Marfan Syndrome
Tay-Sachs disease - ANSWER-Coronary artery disease
Fortification of foods with folic acid has resulted in a significant reduction in the
incidence of - ANSWER-neural tube defects
Which of the following chromosomal abnormalities can result in an inheritable form of
trisomy?
Nondisjunction during meiosis
Balanced translocation
Insertion
Deletion - ANSWER-Balanced translocation
Which type of hemoglobin is produced during sickle-cell crisis? - ANSWER-HbS
Mitochondrial gene disorders are transmitted to - ANSWER-both daughters and sons
Mitochondrial genes produce proteins involved in - ANSWER-energy metabolism
What is a manifestation of Down Syndrome? - ANSWER-Epicanthal eye folds
Which prenatal test(s) diagnose Down Syndrome? - ANSWER-Karyotype
What is the risk of a mother with the genetic mutation that causes Fragile-X
syndrome passing the gene on to an offspring? - ANSWER-50% of males affected
Which chromosomal abnormality is incompatible with life? - ANSWER-Monosomy 21
Affects females only - ANSWER-Turner syndrome
The target of damage in Huntington's Disease - ANSWER-nerve tissue
Maternal serum alpha-fetoprotein (MSAFP) is a screening test for which condition? -
ANSWER-Spina Bifida
A patient comes to the clinic concerned about a painless lymph node in the neck. A
diagnosis of lymphoma is made. Which of the following would indicate the lymphoma
was Hodgkin lymphoma?
The location of the enlarged lymph nodes
The presence of Reed-Sternberg cells
, Spread to the spleen, liver, and bone marrow
The age of the patient - ANSWER-The presence of Reed-Sternberg cells
Which of the following genes, when mutated, is NOT implicated in the development
of neoplasms?
Carcinogenesis
Tumor suppressor genes
Oncogenesis
Mutator genes - ANSWER-Cancinogenes
Which of the following cells is least likely to develop into a neoplasia?
p53 gene
Rb gene
T21 gene - ANSWER-p53 gene
Which of the following is a characteristic of benign neoplasms?
Highly undifferentiated
Invasive
Destructive
Cell Overproliferation - ANSWER-Cell overproliferation
What is the most significant difference between acute lymphocytic and acute
myelogenous leukemia? - ANSWER-Cell type affected
Your grandfather has colon cancer but then it migrated to the liver. The affinity for
movement to another specific organ is called - ANSWER-Tropism
You are a public health official and want to make the greatest difference in reducing
cancer deaths across the globe. Which intervention would have the greatest impact?
- ANSWER-Smoking cessation programs
What sign/symptom might indicate that you are experiencing a paraneoplastic
syndrome? - ANSWER-Edema
What type of cancer would most likely spread through the process called seeding? -
ANSWER-Ovarian
Which of the following is an example of a strong acid?
Albumin
Inorganic phosphorus
Sodium
Lactate - ANSWER-Lactate
Fluid loss in response to hypervolemia is promoted by - ANSWER-Inhibiting the
secretion of aldosterone, promoting urinary sodium and water elimination
What ion is most closely related to water movement? - ANSWER-Sodium
