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Summary Genetics

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This is a summary sheet of everything you need to know on a genetics GCSE Combined Science Topic Test and GCSE Combined Science Paper 1

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January 31, 2026
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2025/2026
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CB3a Meiosis

1. Gametes are produced by meiosis
o Meiosis is a type of cell division that creates gametes (sperm and egg cells).
o It reduces the chromosome number by half, producing haploid cells (23
chromosomes in humans).
2. What happens in meiosis (overview)
o One diploid cell divides twice to form four haploid cells.
o Each gamete is genetically unique due to crossing over and independent
assortment.
3. Why haploid gametes are needed
o During fertilisation, two gametes fuse to form a zygote.
o If gametes weren’t haploid, the zygote would have double the
chromosomes.
4. What is an organism’s genome?
o The genome is the complete set of DNA, including all genes, in an organism.
o It contains instructions for building and maintaining the organism.
5. Function of genes
o Genes code for proteins, which carry out functions and determine traits.
o Each gene has a specific role, like eye colour or enzyme production.
6. Where genes are found

 Genes are located on chromosomes inside the nucleus of eukaryotic cells.

CB3b DNA

1. Where DNA is found
o DNA is found in the nucleus of eukaryotic cells, tightly coiled into
chromosomes.
2. Name the bases in DNA
o The four bases are:
o Adenine (A)
o Thymine (T)
o Cytosine (C)
o Guanine (G)
3. Base pairing rules
o A pairs with T
o C pairs with G
o These pairs are held together by hydrogen bonds.
4. How DNA strands are held together
o The bases form pairs in the middle, and the sugar-phosphate backbone runs
along the sides.
o Hydrogen bonds between base pairs keep the strands together.
5. Structure of DNA
o DNA is a double helix—two strands twisted like a ladder.
o The sides are made of sugar and phosphate; the rungs are base pairs.
6. Extracting DNA from fruit

Steps:

 Mash fruit to break cells
 Add detergent and salt to dissolve membranes
 Filter the mixture
 Add cold alcohol—DNA appears as white strands
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