Genomic Therapy (BIO318) | 25+ Verified Definitions on Viral Vectors, Gene Delivery, AAV, Gag/Pol/Env Genes

This document presents over 25 expert-verified key terms and definitions essential for mastering concepts in Genomic Therapy as covered in the BIO318 course. It serves as a precise glossary for students studying genetic medicine, gene therapy mechanisms, and biotechnology. The content includes clear definitions of fundamental terms such as germ-line vs. somatic gene therapy, in vivo vs. ex vivo delivery, transfection, transduction, and the use of mammalian artificial chromosomes (MACs) and viral vectors (e.g., AAV). Also featured are specialized molecular biology terms relevant to HIV-based vectors, such as the gag, pol, and env genes, which encode structural and enzymatic proteins crucial to retroviral gene delivery systems. Other concepts include LTR (long terminal repeats), transduction units (TUs), titre, and oncogenesis, providing a molecular and clinical bridge between therapy development and safety considerations. This document is a concise study tool ideal for: Undergraduate students in Genetics, Molecular Biology, or Biomedical Science Students in gene therapy, virology, or clinical genetics modules Graduate-level learners or lab interns needing to grasp therapeutic vector terminology Medical and pharmacy students learning gene-based therapeutic platforms Its compact structure makes it especially useful as a revision guide or glossary companion for lectures, exams, or lab discussions in genomic therapy and gene editing courses. Keywords: gene therapy, somatic therapy, germ-line therapy, transfection, transduction, AAV, in vivo, ex vivo, MACs, transduction units, therapeutic vectors, oncogenesis, mutagenesis, LTR, gag gene, pol gene, env gene, good manufacturing practices, HIV gene therapy