Medical-Surgical Nursing Fast Revision MCQs Study Guide & Practice Question Bank

Harrison's Principles of Internal Medicine
(Vol.1 & Vol.2)
22nd Edition
• Author(s)Joseph Loscalzo; Anthony S.
Fauci; Dennis L. Kasper; Stephen Hauser;
Dan Longo; J. Larry Jameson
Test Bank




Covered

PART 1: Foundations of Clinical Medicine

PART 2: Cardinal Symptoms & Clinical Presentations

PART 3: Clinical Pharmacology

PART 4: Oncology & Hematology

PART 5: Infectious Diseases

PART 6: Cardiovascular Disorders

PART 7: Respiratory Disorders

PART 8: Critical Care Medicine

PART 9: Kidney & Urinary Tract Disorders

PART 10: Gastrointestinal & Hepatobiliary Disorders

,PART 11: Immune-Mediated & Rheumatologic Disorders

PART 12: Endocrinology & Metabolism

PART 13: Neurologic & Psychiatric Disorders

PART 14: Toxicology & Environmental Injury

PART 15: Environmental & Occupational Medicine

PART 16: Genetics, Precision & Systems Medicine

PART 17–20: Special & Emerging Topics




Harrison’s Principles of Internal Medicine, 22nd ed.
1. Which principle best defines the modern practice of
medicine as described in Harrison’s?
A. Reliance on technological diagnostics over clinical judgment
B. Integration of scientific evidence with compassionate patient
care
C. Standardized protocols applied uniformly to all patients
D. Emphasis on curative treatment rather than prevention
Correct Answer: B
Rationale: Harrison’s emphasizes medicine as both a science
and a humanistic practice integrating evidence-based
knowledge with patient-centered care.
Citation: Harrison’s Principles of Internal Medicine, 22nd ed.,
Chapter 1 – The Practice of Medicine

,2. Which factor has the greatest impact on population health
outcomes?
A. Access to tertiary care centers
B. Genetic predisposition
C. Social and behavioral determinants
D. Advanced pharmaceutical therapies
Correct Answer: C
Rationale: Harrison’s identifies social, economic, and behavioral
factors as major drivers of population health outcomes.
Citation: Harrison’s, 22nd ed., Chapter 2 – Promoting Good
Health


3. Vaccine hesitancy is most commonly driven by which
concern?
A. Cost of immunization
B. Distrust in health systems and misinformation
C. Religious contraindications
D. Lack of vaccine availability
Correct Answer: B
Rationale: Harrison’s highlights misinformation and lack of trust
as primary contributors to vaccine opposition.
Citation: Harrison’s, 22nd ed., Chapter 3 – Vaccine Opposition
and Hesitancy

, 4. Clinical decision-making under uncertainty most relies on
which approach?
A. Intuition-based judgment
B. Algorithmic diagnosis alone
C. Probabilistic reasoning and risk assessment
D. Patient preference only
Correct Answer: C
Rationale: Harrison’s emphasizes probabilistic reasoning as
central to diagnostic and therapeutic decision-making.
Citation: Harrison’s, 22nd ed., Chapter 4 – Decision-Making in
Clinical Medicine


5. Precision medicine primarily aims to:
A. Replace population-based guidelines
B. Tailor care based on individual variability
C. Focus exclusively on genomic data
D. Eliminate clinical judgment
Correct Answer: B
Rationale: Precision medicine integrates genetic,
environmental, and lifestyle factors to individualize care.
Citation: Harrison’s, 22nd ed., Chapter 5 – Precision Medicine
and Clinical Care


6. An effective screening program must demonstrate: