Medical-Surgical Nursing Practice MCQs – Harrison’s Internal Medicine Study Guide

Harrison's Principles of Internal Medicine
(Vol.1 & Vol.2)
22nd Edition
• Author(s)Joseph Loscalzo; Anthony S.
Fauci; Dennis L. Kasper; Stephen Hauser;
Dan Longo; J. Larry Jameson
Test Bank




Covered

PART 1: Foundations of Clinical Medicine

PART 2: Cardinal Symptoms & Clinical Presentations

PART 3: Clinical Pharmacology

PART 4: Oncology & Hematology

PART 5: Infectious Diseases

PART 6: Cardiovascular Disorders

PART 7: Respiratory Disorders

PART 8: Critical Care Medicine

PART 9: Kidney & Urinary Tract Disorders

PART 10: Gastrointestinal & Hepatobiliary Disorders

,PART 11: Immune-Mediated & Rheumatologic Disorders

PART 12: Endocrinology & Metabolism

PART 13: Neurologic & Psychiatric Disorders

PART 14: Toxicology & Environmental Injury

PART 15: Environmental & Occupational Medicine

PART 16: Genetics, Precision & Systems Medicine

PART 17–20: Special & Emerging Topics




1.
Which principle best distinguishes the practice of medicine as
described in Harrison’s?
A. Reliance on diagnostic technology over clinical reasoning
B. Application of population-based guidelines without
individualization
C. Integration of scientific evidence with patient-centered
judgment
D. Prioritization of cost containment over outcomes
Correct Answer: C
Rationale: Harrison’s emphasizes medicine as the integration of
biomedical science with individualized clinical judgment and
patient values.
Citation: Harrison’s Principles of Internal Medicine, 22nd ed.,
Ch. 1 – The Practice of Medicine


2.

,Which nursing action best supports health promotion at the
population level?
A. Administering acute pharmacologic therapy
B. Screening only symptomatic individuals
C. Addressing social and behavioral determinants of health
D. Focusing exclusively on genetic risk
Correct Answer: C
Rationale: Harrison’s highlights that health promotion requires
addressing behavioral, environmental, and social determinants
of health.
Citation: Harrison’s Principles of Internal Medicine, 22nd ed.,
Ch. 2 – Promoting Good Health


3.
A patient expresses concern that vaccines weaken the immune
system. What is the most appropriate nursing response based
on Harrison’s?
A. Acknowledge the belief and avoid discussion
B. Provide clear, evidence-based education addressing
misconceptions
C. Emphasize mandatory compliance
D. Redirect the discussion to unrelated preventive care
Correct Answer: B
Rationale: Vaccine hesitancy is best addressed through
respectful, evidence-based communication that builds trust.

, Citation: Harrison’s Principles of Internal Medicine, 22nd ed.,
Ch. 3 – Vaccine Opposition and Hesitancy


4.
Which factor most strongly contributes to sound clinical
decision-making?
A. Diagnostic testing prior to history
B. Anchoring on the initial diagnosis
C. Probabilistic reasoning using pretest likelihoods
D. Reliance on clinical intuition alone
Correct Answer: C
Rationale: Harrison’s emphasizes probabilistic thinking and
Bayesian reasoning to guide diagnostic and therapeutic
decisions.
Citation: Harrison’s Principles of Internal Medicine, 22nd ed.,
Ch. 4 – Decision-Making in Clinical Medicine


5.
Precision medicine primarily aims to:
A. Replace clinical assessment with genomics
B. Standardize treatment across populations
C. Tailor prevention and treatment using individual variability
D. Eliminate environmental risk assessment