Harrison's Principles of Internal Medicine
(Vol.1 & Vol.2)
22nd Edition
• Author(s)Joseph Loscalzo; Anthony S.
Fauci; Dennis L. Kasper; Stephen Hauser;
Dan Longo; J. Larry Jameson
Test Bank
Covered
PART 1: Foundations of Clinical Medicine
PART 2: Cardinal Symptoms & Clinical Presentations
PART 3: Clinical Pharmacology
PART 4: Oncology & Hematology
PART 5: Infectious Diseases
PART 6: Cardiovascular Disorders
PART 7: Respiratory Disorders
PART 8: Critical Care Medicine
PART 9: Kidney & Urinary Tract Disorders
PART 10: Gastrointestinal & Hepatobiliary Disorders
,PART 11: Immune-Mediated & Rheumatologic Disorders
PART 12: Endocrinology & Metabolism
PART 13: Neurologic & Psychiatric Disorders
PART 14: Toxicology & Environmental Injury
PART 15: Environmental & Occupational Medicine
PART 16: Genetics, Precision & Systems Medicine
PART 17–20: Special & Emerging Topics
1. The Practice of Medicine
Which principle best defines evidence-based medical practice
as described in Harrison’s?
A. Reliance on expert opinion
B. Use of pathophysiologic reasoning alone
C. Integration of best research evidence with clinical expertise
and patient values
D. Standardization of care across all patients
Correct Answer: C
Rationale: Evidence-based medicine combines high-quality
evidence, clinician judgment, and patient preferences.
Citation: Harrison’s Principles of Internal Medicine, 22nd ed.,
Ch. 1
,2. Promoting Good Health
Which intervention provides the greatest population-level
reduction in preventable mortality?
A. Genetic screening
B. Lifestyle modification
C. Advanced diagnostics
D. Tertiary medical care
Correct Answer: B
Rationale: Lifestyle interventions (smoking cessation, diet,
exercise) have the largest impact on morbidity and mortality.
Citation: Harrison’s, 22nd ed., Ch. 2
3. Vaccine Opposition and Hesitancy
Which factor is most strongly associated with vaccine
hesitancy?
A. Scientific illiteracy
B. Prior adverse events
C. Distrust in institutions
D. Lack of access
Correct Answer: C
Rationale: Harrison’s emphasizes mistrust of health systems
and authorities as a primary driver of hesitancy.
Citation: Harrison’s, 22nd ed., Ch. 3
, 4. Decision-Making in Clinical Medicine
Shared decision-making is MOST appropriate when:
A. Evidence strongly favors one option
B. The condition is life-threatening
C. Multiple reasonable options exist
D. The patient lacks medical knowledge
Correct Answer: C
Rationale: Shared decision-making is critical when benefits and
risks are closely balanced.
Citation: Harrison’s, 22nd ed., Ch. 4
5. Precision Medicine and Clinical Care
Precision medicine primarily aims to:
A. Replace clinical judgment
B. Individualize prevention and treatment
C. Reduce health care costs
D. Eliminate population-based guidelines
Correct Answer: B
Rationale: Precision medicine integrates genetic,
environmental, and lifestyle data to individualize care.
Citation: Harrison’s, 22nd ed., Ch. 5
6. Screening and Prevention of Disease
(Vol.1 & Vol.2)
22nd Edition
• Author(s)Joseph Loscalzo; Anthony S.
Fauci; Dennis L. Kasper; Stephen Hauser;
Dan Longo; J. Larry Jameson
Test Bank
Covered
PART 1: Foundations of Clinical Medicine
PART 2: Cardinal Symptoms & Clinical Presentations
PART 3: Clinical Pharmacology
PART 4: Oncology & Hematology
PART 5: Infectious Diseases
PART 6: Cardiovascular Disorders
PART 7: Respiratory Disorders
PART 8: Critical Care Medicine
PART 9: Kidney & Urinary Tract Disorders
PART 10: Gastrointestinal & Hepatobiliary Disorders
,PART 11: Immune-Mediated & Rheumatologic Disorders
PART 12: Endocrinology & Metabolism
PART 13: Neurologic & Psychiatric Disorders
PART 14: Toxicology & Environmental Injury
PART 15: Environmental & Occupational Medicine
PART 16: Genetics, Precision & Systems Medicine
PART 17–20: Special & Emerging Topics
1. The Practice of Medicine
Which principle best defines evidence-based medical practice
as described in Harrison’s?
A. Reliance on expert opinion
B. Use of pathophysiologic reasoning alone
C. Integration of best research evidence with clinical expertise
and patient values
D. Standardization of care across all patients
Correct Answer: C
Rationale: Evidence-based medicine combines high-quality
evidence, clinician judgment, and patient preferences.
Citation: Harrison’s Principles of Internal Medicine, 22nd ed.,
Ch. 1
,2. Promoting Good Health
Which intervention provides the greatest population-level
reduction in preventable mortality?
A. Genetic screening
B. Lifestyle modification
C. Advanced diagnostics
D. Tertiary medical care
Correct Answer: B
Rationale: Lifestyle interventions (smoking cessation, diet,
exercise) have the largest impact on morbidity and mortality.
Citation: Harrison’s, 22nd ed., Ch. 2
3. Vaccine Opposition and Hesitancy
Which factor is most strongly associated with vaccine
hesitancy?
A. Scientific illiteracy
B. Prior adverse events
C. Distrust in institutions
D. Lack of access
Correct Answer: C
Rationale: Harrison’s emphasizes mistrust of health systems
and authorities as a primary driver of hesitancy.
Citation: Harrison’s, 22nd ed., Ch. 3
, 4. Decision-Making in Clinical Medicine
Shared decision-making is MOST appropriate when:
A. Evidence strongly favors one option
B. The condition is life-threatening
C. Multiple reasonable options exist
D. The patient lacks medical knowledge
Correct Answer: C
Rationale: Shared decision-making is critical when benefits and
risks are closely balanced.
Citation: Harrison’s, 22nd ed., Ch. 4
5. Precision Medicine and Clinical Care
Precision medicine primarily aims to:
A. Replace clinical judgment
B. Individualize prevention and treatment
C. Reduce health care costs
D. Eliminate population-based guidelines
Correct Answer: B
Rationale: Precision medicine integrates genetic,
environmental, and lifestyle data to individualize care.
Citation: Harrison’s, 22nd ed., Ch. 5
6. Screening and Prevention of Disease
