Medical-Surgical Nursing MCQ Study Guide & Practice Test Bank

Harrison's Principles of Internal Medicine
(Vol.1 & Vol.2)
22nd Edition
• Author(s)Joseph Loscalzo; Anthony S.
Fauci; Dennis L. Kasper; Stephen Hauser;
Dan Longo; J. Larry Jameson
Test Bank




Covered

PART 1: Foundations of Clinical Medicine

PART 2: Cardinal Symptoms & Clinical Presentations

PART 3: Clinical Pharmacology

PART 4: Oncology & Hematology

PART 5: Infectious Diseases

PART 6: Cardiovascular Disorders

PART 7: Respiratory Disorders

PART 8: Critical Care Medicine

PART 9: Kidney & Urinary Tract Disorders

PART 10: Gastrointestinal & Hepatobiliary Disorders

,PART 11: Immune-Mediated & Rheumatologic Disorders

PART 12: Endocrinology & Metabolism

PART 13: Neurologic & Psychiatric Disorders

PART 14: Toxicology & Environmental Injury

PART 15: Environmental & Occupational Medicine

PART 16: Genetics, Precision & Systems Medicine

PART 17–20: Special & Emerging Topics




1. The Practice of Medicine
Q1. Which principle best characterizes modern internal
medicine practice as described in Harrison’s?
A. Disease-centered intervention
B. Algorithm-driven care alone
C. Integration of science, clinical reasoning, and humanism
D. Technology-first diagnosis
Correct Answer: C
Rationale: Harrison’s emphasizes that effective medical practice
integrates biomedical science, clinical expertise, and
compassionate patient-centered care.
Citation: Harrison’s 22nd ed., Ch. 1 – The Practice of Medicine


2. Promoting Good Health

,Q2. Which intervention has the greatest population-level
impact on reducing morbidity and mortality?
A. Tertiary care services
B. Individualized genomic therapy
C. Preventive public health measures
D. Advanced diagnostic imaging
Correct Answer: C
Rationale: Harrison’s highlights prevention (e.g., sanitation,
vaccination, lifestyle modification) as the most impactful
determinant of population health.
Citation: Harrison’s 22nd ed., Ch. 2 – Promoting Good Health


3. Vaccine Opposition and Hesitancy
Q3. What is the most effective clinician response to vaccine
hesitancy?
A. Dismissal of parental concerns
B. Provision of clear, empathetic, evidence-based
communication
C. Legal enforcement of vaccination
D. Use of fear-based messaging
Correct Answer: B
Rationale: Harrison’s stresses trust-building, respectful
dialogue, and addressing misinformation as key strategies.
Citation: Harrison’s 22nd ed., Ch. 3 – Vaccine Opposition and
Hesitancy

, 4. Decision-Making in Clinical Medicine
Q4. Clinical decision-making under uncertainty primarily relies
on which concept?
A. Intuition alone
B. Deterministic reasoning
C. Probabilistic thinking using pretest and posttest probability
D. Diagnostic certainty before intervention
Correct Answer: C
Rationale: Harrison’s emphasizes Bayesian reasoning to refine
diagnostic probability and guide decisions.
Citation: Harrison’s 22nd ed., Ch. 4 – Decision-Making in Clinical
Medicine


5. Precision Medicine and Clinical Care
Q5. Precision medicine primarily aims to:
A. Replace clinical assessment
B. Apply population averages to all patients
C. Tailor prevention and treatment based on individual
variability
D. Focus exclusively on genetic testing
Correct Answer: C
Rationale: Harrison’s defines precision medicine as integrating
genetics, environment, and lifestyle into care.