Page | 1
NR 565 - ADVANCED PHARMACOLOGY
MIDTERM – CHAMBERLAIN 2026
QUESTIONS AND ANSWERS | A+
GRADED | WITH EXPERT SOLUTIONS
During what trimester is a pregnant woman most at risk for
adverse drug reactions with potential long term consequences? -
correct answer-1st trimester (fetus most at risk d/t rapid growth)
What is BEERS criteria? - correct answer-Recommendations of
medications inappropriate for elderly (65 and older), prescriber
ultimately decides
What is the CYP450 (cytochrome P450) - correct answer-liver
enzyme system where medications are metabolized, can either
be inducers or inhibitors and create drug-drug interactions
CYP450 inducers - correct answer-Speed up metabolism of drugs
(drug is cleared faster), drug has lesser effect (decrease blood
levels of drug), elevate CYP450 enzymes
, Page | 2
CYP450 inducers pneumonic - correct answer-"Bullshit Crap GPS
INDUCES rage"
CYP450 inducer drug names - correct answer-Barbituates, St
John wort, Carbamazepine, rifampin, alcohol, phenytoin,
griseofulvin, phenobarbital, sulfonylureas
CYP450 inhibitors - correct answer-inhibit metabolism, increase
blood levels of medications
CYP450 pneumonic - correct answer-"VISA credit card debt
INHIBITS spending on designers like CK to look GQ"
CYP450 inhibitors drug names - correct answer-Valproate,
isoniazid, sulfonamides, amiodarone, chloramphenicol,
ketoconazole, grapefruit juice, quinidine
Physiological changes during pregnancy that impact
pharmacodynamics and pharmacokinetic properties of drugs? -
, Page | 3
correct answer-increase glomerular filtration rate leads to
increase durg excretion
increase hepatic metabolism
decrease tone and motility of bowel
increase drug absorption
Examples of medications that can be teratogenic - correct
answer-Antiepileptic drugs, antimicrobials such as tetracyclines
and fluoroquinolones, vitamin A in large doses, some
anticoagulants, and hormonal medications such as
diethylstilbestrol (DES).
How is absorption of intramuscular medications different in
neonates? - correct answer-slow and erratic due to low blood flow
in muscles first few days of life
Why is absorption of medication in the stomach increased in
infancy? - correct answer-delayed gastric emptying
Some medications that should be avoided in the pediatric patient?
- correct answer-glucocorticoids, discoloration of developing teeth
, Page | 4
with tetracyclines, and kernicterus with sulfonamides, levofloxacin
(antibiotics)
aspirin (Severe intoxication from acute overdose)
what should be included in medication administration patient
education? - correct answer-dosage size and timing
route and technique of administration
duration of treatment
drug storage
nature and time course of desired responses
nature and time course of adverse responses
finish taking antibiotic
What are some things that put the elderly patient at higher risk for
adverse drug reactions? - correct answer-reduced renal function
polypharmacy (the use of five or more medications daily)
greater severity of illness
presence of comorbidities
use of drugs that have a low therapeutic index (e.g., digoxin)
increased individual variation secondary to altered
pharmacokinetics
inadequate supervision of long-term therapy
NR 565 - ADVANCED PHARMACOLOGY
MIDTERM – CHAMBERLAIN 2026
QUESTIONS AND ANSWERS | A+
GRADED | WITH EXPERT SOLUTIONS
During what trimester is a pregnant woman most at risk for
adverse drug reactions with potential long term consequences? -
correct answer-1st trimester (fetus most at risk d/t rapid growth)
What is BEERS criteria? - correct answer-Recommendations of
medications inappropriate for elderly (65 and older), prescriber
ultimately decides
What is the CYP450 (cytochrome P450) - correct answer-liver
enzyme system where medications are metabolized, can either
be inducers or inhibitors and create drug-drug interactions
CYP450 inducers - correct answer-Speed up metabolism of drugs
(drug is cleared faster), drug has lesser effect (decrease blood
levels of drug), elevate CYP450 enzymes
, Page | 2
CYP450 inducers pneumonic - correct answer-"Bullshit Crap GPS
INDUCES rage"
CYP450 inducer drug names - correct answer-Barbituates, St
John wort, Carbamazepine, rifampin, alcohol, phenytoin,
griseofulvin, phenobarbital, sulfonylureas
CYP450 inhibitors - correct answer-inhibit metabolism, increase
blood levels of medications
CYP450 pneumonic - correct answer-"VISA credit card debt
INHIBITS spending on designers like CK to look GQ"
CYP450 inhibitors drug names - correct answer-Valproate,
isoniazid, sulfonamides, amiodarone, chloramphenicol,
ketoconazole, grapefruit juice, quinidine
Physiological changes during pregnancy that impact
pharmacodynamics and pharmacokinetic properties of drugs? -
, Page | 3
correct answer-increase glomerular filtration rate leads to
increase durg excretion
increase hepatic metabolism
decrease tone and motility of bowel
increase drug absorption
Examples of medications that can be teratogenic - correct
answer-Antiepileptic drugs, antimicrobials such as tetracyclines
and fluoroquinolones, vitamin A in large doses, some
anticoagulants, and hormonal medications such as
diethylstilbestrol (DES).
How is absorption of intramuscular medications different in
neonates? - correct answer-slow and erratic due to low blood flow
in muscles first few days of life
Why is absorption of medication in the stomach increased in
infancy? - correct answer-delayed gastric emptying
Some medications that should be avoided in the pediatric patient?
- correct answer-glucocorticoids, discoloration of developing teeth
, Page | 4
with tetracyclines, and kernicterus with sulfonamides, levofloxacin
(antibiotics)
aspirin (Severe intoxication from acute overdose)
what should be included in medication administration patient
education? - correct answer-dosage size and timing
route and technique of administration
duration of treatment
drug storage
nature and time course of desired responses
nature and time course of adverse responses
finish taking antibiotic
What are some things that put the elderly patient at higher risk for
adverse drug reactions? - correct answer-reduced renal function
polypharmacy (the use of five or more medications daily)
greater severity of illness
presence of comorbidities
use of drugs that have a low therapeutic index (e.g., digoxin)
increased individual variation secondary to altered
pharmacokinetics
inadequate supervision of long-term therapy
