NURS 5334 Advanced Pharm: Final Exam |
Questions and Answers | 2025 Update | 100%
Correct – UTA.
Advanced Pharm: Final Exam
1. Charlie is a 65-year-old male who has been diagnosed with hypertension and
benign prostatic hyperplasia. Doxazosin has been chosen to treat his
hypertension because it:
1. Increases peripheral vasoconstriction
2. Decreases detrusor muscle contractility
3. Lowers supine blood pressure more than standing pressure
4. Relaxes smooth muscle in the bladder neck
4. Relaxes smooth muscle in the bladder neck
2. To reduce potential adverse effects, patients taking a peripherally acting alpha1
antagonist should do all of the following EXCEPT:
1. Take the dose at bedtime
2. Sit up slowly and dangle their feet before standing
3. Monitor their blood pressure and skip a dose if the pressure is less than
120/80
4. Weigh daily and report weight gain of greater than 2 pounds in one day
3. Monitor their blood pressure and skip a dose if the pressure is less than
120/80
3. John has clonidine, a centrally-acting adrenergic blocker, prescribed for his
hypertension. He should:
1. Not miss a dose or stop taking the drug because of potential rebound
hypertension
2. Increase fiber in the diet to treat any diarrhea that may occur
3. Reduce fluid intake to less than 2 liters per day to prevent fluid retention
4. Avoid sitting for long periods, as this can lead to deep vein thrombosis
1. Not miss a dose or stop taking the drug because of potential rebound
hypertension
,4. Clonidine has several off-label uses, including:
1. Alcohol and nicotine withdrawal
2. Post-herpetic neuralgia
3. Both 1 and 2
4. Neither 1 nor 2
3. Both 1 and 2
5. Jim is being treated for hypertension. Because he has a history of heart
attacks, the drug chosen is atenolol. Beta-blockers treat hypertension by:
1. Increasing heart rate to improve cardiac output
2. Reducing vascular smooth muscle tone
3. Increasing aldosterone-mediated volume activity
4. Reducing aqueous humor production
2. Reducing vascular smooth muscle tone
6. Which of the following adverse effects are less likely in a beta 1-selective
blocker?
1. Dysrhythmias
2. Impaired insulin release
3. Reflex orthostatic changes
4. Decreased triglycerides and cholesterol
2. Impaired insulin release
7. Richard is 70 years old and has a history of cardiac dysrhythmias. He has been
prescribed nadolol. You do his annual laboratory work and find a CrCl of 25
ml/min. What action should you take related to his nadolol?
1. Extend the dosage interval.
2. Decrease the dose by 75%.
3. Take no action because this value is expected in the older adult.
4. Schedule a serum creatinine level to validate the CrCl value.
1. Extend the dosage interval.
8. Beta blockers are the drugs of choice for exertional angina because they:
1. Improve myocardial oxygen supply by vasodilating the coronary arteries
2. Decrease myocardial oxygen demand by decreasing heart rate and vascular
resistance
3. Both 1 and 2
4. Neither 1 nor 2
2. Decrease myocardial oxygen demand by decreasing heart rate and vascular
resistance
9. Adherence to beta-blocker therapy may be affected by their:
, 1. Short half-lives requiring twice daily dosing
2. Tendency to elevate lipid levels
3. Effects on the male genitalia, which may produce impotence
g g g g g g g g
4. None of the above g g g
3. Effects on the male genitalia, which may produce impotence
g g g g g g g g
10. Beta-blockers have favorable effects on survival and disease progression in g g g g g g g g g
heart failure. Treatment should be initiated when the:
g g g g g g g g
1. Symptoms are severe g g
2. Patient has not responded to other therapies g g g g g g
3. Patient has concurrent hypertension g g g
4. Left ventricular dysfunction is diagnosed
g g g g
4. Left ventricular dysfunction is diagnosed
g g g g g
11. Abrupt withdrawal of beta blockers can be life-threatening. Patients at the
g g g g g g g g g g
highest risk for serious consequences of rapid withdrawal are those with:
g g g g g g g g g g g
1. Angina
2. Coronary artery disease g g
3. Both 1 and 2 g g g
4. Neither 1 nor 2 g g g
3. Both 1 and 2
g g g g
12. To prevent life-threatening events from rapid withdrawal of a beta blocker:
g g g g g g g g g g
1. The dosage interval should be increased by 1 hour each day.
g g g g g g g g g g
2. An alpha blocker should be added to the treatment regimen before withdrawal.
g g g g g g g g g g g
3. The dosage should be tapered over a period of weeks.
g g g g g g g g g
4. The dosage should be decreased by one-half every 4 days.
g g g g g g g g g
4. The dosage should be decreased by one-half every 4 days.
g g g g g g g g g g
13. Beta-blockers are prescribed for diabetics with caution because of their abilityg g g g g g g g g g
to produce hypoglycemia and block the common symptoms of it. Which of the
g g g g g g g g g g g g g
following symptoms of hypoglycemia is not blocked by these drugs and so can be
g g g g g g g g g g g g g g
used to warn diabetics of possible decreased blood glucose?
g g g g g g g g g
1. Dizziness
2. Increased heart rate g g
3. Nervousness and shakiness g g
4. Diaphoresis
4. Diaphoresis
g
, 14. Combined alpha-beta antagonists are used to reduce the progression of heart
g g g g g g g g g g
failure because they:
g g g
1. Vasodilate the peripheral vasculature g g g
2. Decrease cardiac output g g
3. Increase renal vascular resistance g g g
4. Reduce atherosclerosis secondary to elevated serum lipoproteins
g g g g g g
1. Vasodilate the peripheral vasculature g g g
15. Carvedilol is heavily metabolized by CYP2D6 and 2C9, resulting in drug
g g g g g g g g g g
interactions with which of the following drug classes?
g g g g g g g g
1. Histamine 2 blockers g g
2. Quinolones
3. Serotonin re-uptake inhibitors g g
4. All of the above
g g g
4. All of the above
g g g g
16. Alpha-beta blockers are especially effective in treating hypertension for which
g g g g g g g g g
ethnic group?
g g
1. White
2. Asian
3. African American g
4. Native American g
3. African American
g g
17. Bethanechol:
1. Increases detrusor muscle tone to empty the bladder g g g g g g g
2. Decreases gastric acid secretion to treat peptic ulcer disease g g g g g g g g
3. Stimulates voluntary muscle tone to improve strength g g g g g g
4. Reduces bronchial airway constriction to treat asthma
g g g g g g
1. Increases detrusor muscle tone to empty the bladder g g g g g g g
18. Clinical dosing of Bethanechol:
g g g
1. Begins at the highest effective dose to obtain a rapid response
g g g g g g g g g g
2. Starts at 5 mg to 10 mg PO and is repeated every hour until a satisfactory
g g g g g g g g g g g g g g g
clinical response is achieved
g g g g
3. Requires dosing only once daily g g g g
Questions and Answers | 2025 Update | 100%
Correct – UTA.
Advanced Pharm: Final Exam
1. Charlie is a 65-year-old male who has been diagnosed with hypertension and
benign prostatic hyperplasia. Doxazosin has been chosen to treat his
hypertension because it:
1. Increases peripheral vasoconstriction
2. Decreases detrusor muscle contractility
3. Lowers supine blood pressure more than standing pressure
4. Relaxes smooth muscle in the bladder neck
4. Relaxes smooth muscle in the bladder neck
2. To reduce potential adverse effects, patients taking a peripherally acting alpha1
antagonist should do all of the following EXCEPT:
1. Take the dose at bedtime
2. Sit up slowly and dangle their feet before standing
3. Monitor their blood pressure and skip a dose if the pressure is less than
120/80
4. Weigh daily and report weight gain of greater than 2 pounds in one day
3. Monitor their blood pressure and skip a dose if the pressure is less than
120/80
3. John has clonidine, a centrally-acting adrenergic blocker, prescribed for his
hypertension. He should:
1. Not miss a dose or stop taking the drug because of potential rebound
hypertension
2. Increase fiber in the diet to treat any diarrhea that may occur
3. Reduce fluid intake to less than 2 liters per day to prevent fluid retention
4. Avoid sitting for long periods, as this can lead to deep vein thrombosis
1. Not miss a dose or stop taking the drug because of potential rebound
hypertension
,4. Clonidine has several off-label uses, including:
1. Alcohol and nicotine withdrawal
2. Post-herpetic neuralgia
3. Both 1 and 2
4. Neither 1 nor 2
3. Both 1 and 2
5. Jim is being treated for hypertension. Because he has a history of heart
attacks, the drug chosen is atenolol. Beta-blockers treat hypertension by:
1. Increasing heart rate to improve cardiac output
2. Reducing vascular smooth muscle tone
3. Increasing aldosterone-mediated volume activity
4. Reducing aqueous humor production
2. Reducing vascular smooth muscle tone
6. Which of the following adverse effects are less likely in a beta 1-selective
blocker?
1. Dysrhythmias
2. Impaired insulin release
3. Reflex orthostatic changes
4. Decreased triglycerides and cholesterol
2. Impaired insulin release
7. Richard is 70 years old and has a history of cardiac dysrhythmias. He has been
prescribed nadolol. You do his annual laboratory work and find a CrCl of 25
ml/min. What action should you take related to his nadolol?
1. Extend the dosage interval.
2. Decrease the dose by 75%.
3. Take no action because this value is expected in the older adult.
4. Schedule a serum creatinine level to validate the CrCl value.
1. Extend the dosage interval.
8. Beta blockers are the drugs of choice for exertional angina because they:
1. Improve myocardial oxygen supply by vasodilating the coronary arteries
2. Decrease myocardial oxygen demand by decreasing heart rate and vascular
resistance
3. Both 1 and 2
4. Neither 1 nor 2
2. Decrease myocardial oxygen demand by decreasing heart rate and vascular
resistance
9. Adherence to beta-blocker therapy may be affected by their:
, 1. Short half-lives requiring twice daily dosing
2. Tendency to elevate lipid levels
3. Effects on the male genitalia, which may produce impotence
g g g g g g g g
4. None of the above g g g
3. Effects on the male genitalia, which may produce impotence
g g g g g g g g
10. Beta-blockers have favorable effects on survival and disease progression in g g g g g g g g g
heart failure. Treatment should be initiated when the:
g g g g g g g g
1. Symptoms are severe g g
2. Patient has not responded to other therapies g g g g g g
3. Patient has concurrent hypertension g g g
4. Left ventricular dysfunction is diagnosed
g g g g
4. Left ventricular dysfunction is diagnosed
g g g g g
11. Abrupt withdrawal of beta blockers can be life-threatening. Patients at the
g g g g g g g g g g
highest risk for serious consequences of rapid withdrawal are those with:
g g g g g g g g g g g
1. Angina
2. Coronary artery disease g g
3. Both 1 and 2 g g g
4. Neither 1 nor 2 g g g
3. Both 1 and 2
g g g g
12. To prevent life-threatening events from rapid withdrawal of a beta blocker:
g g g g g g g g g g
1. The dosage interval should be increased by 1 hour each day.
g g g g g g g g g g
2. An alpha blocker should be added to the treatment regimen before withdrawal.
g g g g g g g g g g g
3. The dosage should be tapered over a period of weeks.
g g g g g g g g g
4. The dosage should be decreased by one-half every 4 days.
g g g g g g g g g
4. The dosage should be decreased by one-half every 4 days.
g g g g g g g g g g
13. Beta-blockers are prescribed for diabetics with caution because of their abilityg g g g g g g g g g
to produce hypoglycemia and block the common symptoms of it. Which of the
g g g g g g g g g g g g g
following symptoms of hypoglycemia is not blocked by these drugs and so can be
g g g g g g g g g g g g g g
used to warn diabetics of possible decreased blood glucose?
g g g g g g g g g
1. Dizziness
2. Increased heart rate g g
3. Nervousness and shakiness g g
4. Diaphoresis
4. Diaphoresis
g
, 14. Combined alpha-beta antagonists are used to reduce the progression of heart
g g g g g g g g g g
failure because they:
g g g
1. Vasodilate the peripheral vasculature g g g
2. Decrease cardiac output g g
3. Increase renal vascular resistance g g g
4. Reduce atherosclerosis secondary to elevated serum lipoproteins
g g g g g g
1. Vasodilate the peripheral vasculature g g g
15. Carvedilol is heavily metabolized by CYP2D6 and 2C9, resulting in drug
g g g g g g g g g g
interactions with which of the following drug classes?
g g g g g g g g
1. Histamine 2 blockers g g
2. Quinolones
3. Serotonin re-uptake inhibitors g g
4. All of the above
g g g
4. All of the above
g g g g
16. Alpha-beta blockers are especially effective in treating hypertension for which
g g g g g g g g g
ethnic group?
g g
1. White
2. Asian
3. African American g
4. Native American g
3. African American
g g
17. Bethanechol:
1. Increases detrusor muscle tone to empty the bladder g g g g g g g
2. Decreases gastric acid secretion to treat peptic ulcer disease g g g g g g g g
3. Stimulates voluntary muscle tone to improve strength g g g g g g
4. Reduces bronchial airway constriction to treat asthma
g g g g g g
1. Increases detrusor muscle tone to empty the bladder g g g g g g g
18. Clinical dosing of Bethanechol:
g g g
1. Begins at the highest effective dose to obtain a rapid response
g g g g g g g g g g
2. Starts at 5 mg to 10 mg PO and is repeated every hour until a satisfactory
g g g g g g g g g g g g g g g
clinical response is achieved
g g g g
3. Requires dosing only once daily g g g g
