Answers | 2026 Update | 100% Correct
1. Which class of drugs is first-line for hypertension in non-pregnant adults?
A) Beta-blockers
B) ACE inhibitors
C) Calcium channel blockers
D) Diuretics
Answer: D) Diuretics
Rationale: Thiazide diuretics are first-line for uncomplicated hypertension; they reduce blood
volume and peripheral resistance.
2. Which electrolyte imbalance is most likely with hydrochlorothiazide?
A) Hyperkalemia
B) Hypokalemia
C) Hypercalcemia
D) Hypermagnesemia
Answer: B) Hypokalemia
Rationale: Thiazides increase potassium excretion; monitor serum potassium and advise
potassium-rich foods.
3. Which drug is a loop diuretic?
A) Furosemide
B) Hydrochlorothiazide
C) Spironolactone
D) Mannitol
Answer: A) Furosemide
Rationale: Loop diuretics act on the Na⁺-K⁺-2Cl⁻ transporter in the loop of Henle, causing potent
diuresis and electrolyte loss.
, 4. Which drug class is potassium-sparing?
A) Thiazides
B) Loop diuretics
C) Spironolactone
D) Osmotic diuretics
Answer: C) Spironolactone
Rationale: Spironolactone antagonizes aldosterone, reducing sodium reabsorption and retaining
potassium; monitor for hyperkalemia.
5. Which antihypertensive is safest in pregnancy?
A) Lisinopril
B) Methyldopa
C) Atenolol
D) Losartan
Answer: B) Methyldopa
Rationale: Methyldopa is well-studied in pregnancy and reduces BP without harming the fetus.
ACE inhibitors and ARBs are contraindicated.
6. Which beta-blocker is cardioselective?
A) Propranolol
B) Metoprolol
C) Carvedilol
D) Labetalol
Answer: B) Metoprolol
Rationale: Beta-1 selective, reducing heart rate and contractility with less bronchospasm risk.
7. Which beta-blocker also blocks alpha receptors?
A) Metoprolol
B) Labetalol