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NURS 6521 (ADVANCED NURSING PRACTICE, PHARMACOLOGY, PATHOPHYSIOLOGY, RESEARCH METHODS AND EVIDENCE- BASED PRACTICE) MIDTERM EXAM QUESTIONS AND ANSWERS

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NURS 6521 (ADVANCED NURSING PRACTICE, PHARMACOLOGY, PATHOPHYSIOLOGY, RESEARCH METHODS AND EVIDENCE- BASED PRACTICE) MIDTERM EXAM QUESTIONS AND ANSWERS

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Institution
NURS 6521
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NURS 6521

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Uploaded on
January 16, 2026
Number of pages
378
Written in
2025/2026
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NURS 6521 (ADVANCED NURSING PRACTICE, PHARMACOLOGY,
PATHOPHYSIOLOGY, RESEARCH METHODS AND EVIDENCE-
BASED PRACTICE) MIDTERM EXAM QUESTIONS AND ANSWERS
VERIFIED ANSWERS PLUS RATIONALES



ADVANCED NURSING PRACTICE MIDTERM | | |




1. Which of the following best describes the primary goal of advanced nursing
| | | | | | | | | | |


practice?
|


A. Administer medications efficiently | |


B. Provide direct patient care only | | | |


C. Integrate evidence-based practice to improve patient outcomes
| | | | | |


D. Document care accurately | |




Answer: C |


Rationale: Advanced nursing practice emphasizes the integration of clinical
| | | | | | | |


expertise with research evidence to optimize patient outcomes.
| | | | | | | |




2. An advanced practice nurse (APN) is assessing a patient with hypertension.
| | | | | | | | | |


Which of the following interventions is most evidence-based for initial
| | | | | | | | | |


management?
|


A. Initiate beta-blockers in all patients
| | | |


B. Recommend lifestyle modifications and monitor blood pressure | | | | | |


C. Prescribe diuretics without evaluation | | |


D. Refer immediately to cardiology
| | |




Answer: B |


Rationale: Evidence-based guidelines recommend lifestyle modification as first-
| | | | | | |


line management in most hypertensive patients before pharmacologic
| | | | | | | |


intervention.
|




3. Which model best guides clinical decision-making by integrating patient
| | | | | | | |


preferences, clinical expertise, and research evidence?
| | | | | |


A. Health Belief Model | |


B. PICO Framework |


C. Evidence-Based Practice Model | |


D. Maslow’s Hierarchy of Needs | | |

,Answer: C |


Rationale: The Evidence-Based Practice Model combines best research
| | | | | | |


evidence, clinical expertise, and patient values for optimal care.
| | | | | | | | |




4. A patient presents with chronic pain unresponsive to non-opioid therapy. The
| | | | | | | | | |


APN considers initiating opioid therapy. What is the most important next step?
| | | | | | | | | | | |


A. Prescribe a long-acting opioid immediately | | | |


B. Evaluate risk factors for opioid misuse | | | | |


C. Refer the patient to physical therapy only
| | | | | |


D. Document pain and continue current therapy | | | | |




Answer: B |


Rationale: Assessing risk factors for opioid misuse is critical to ensure safe and
| | | | | | | | | | | |


effective pain management.
| | |




5. Which of the following is a core competency for advanced practice nurses
| | | | | | | | | | |


according to the AACN?
| | | |


A. Independent practice without collaboration | | |


B. Leadership in patient care and system improvement | | | | | |


C. Administrative documentation only | |


D. Sole reliance on standardized protocols
| | | |




Answer: B |


Rationale: Leadership in patient care, systems improvement, and quality
| | | | | | | |


enhancement is a core competency for APNs.
| | | | | | |




6. AnAPN is considering telehealth for a rural patient with diabetes. Which is a
| | | | | | | | | | | | |


primary advantage of telehealth in this scenario?
| | | | | | |


A. Replaces in-person visits entirely | | |


B. Reduces access to care | | |


C. Enhances patient monitoring and education | | | |


D. Limits patient engagement | |




Answer: C |


Rationale: Telehealth improves access, monitoring, and patient education,
| | | | | | |


especially in underserved areas.
| | | |




7. In implementing evidence-based practice, the PICO framework is used to:
| | | | | | | | |


A. Identify financial resources | |


B. Formulate clinical questions | |


C. Replace clinical judgment | |


D. Create patient satisfaction surveys
| | |

,Answer: B |


Rationale: PICO (Population, Intervention, Comparison, Outcome) is used to
| | | | | | | |


develop focused clinical questions for evidence-based practice.
| | | | | | |




8. When managing a patient with multiple comorbidities, theAPN should
| | | | | | | | |


prioritize interventions based on:
| | | |


A. Patient preference only | |


B. Disease severity and potential for harm | | | | |


C. Available hospital resources | |


D. Protocols regardless of context | | |




Answer: B |


Rationale: Prioritization is based on severity, potential harm, and overall impact
| | | | | | | | | |


on patient outcomes.
| | |




9. Which ethical principle emphasizes the obligation to do good for the patient?
| | | | | | | | | | |


A. Autonomy
B. Justice
C. Beneficence
D. Nonmaleficence
Answer: C |


Rationale: Beneficence refers to promoting good and acting in the best interest of
| | | | | | | | | | | |


the patient.
| |




10. Apatient refuses a recommended blood transfusion due to religious beliefs.
| | | | | | | | | |


The APN should:
| | |


A. Ignore the refusal and proceed | | | |


B. Respect autonomy and explore alternative therapies
| | | | |


C. Coerce the patient to consent | | | |


D. Document refusal but do nothing else | | | | |




Answer: B |


Rationale: Respecting patient autonomy while providing information and
| | | | | | |


alternatives is ethically required.
| | | |




11. TheAPN role includes prescriptive authority. Which factor is most critical to
| | | | | | | | | | |


safe prescribing?
| |


A. Familiarity with hospital formulary only | | | |


B. Comprehensive patient assessment | |


C. Prescribing based on patient request | | | |


D. Limiting prescriptions to over-the-counter medications
| | | |

, Answer: B |


Rationale: Safe prescribing relies on thorough assessment of the patient’s health
| | | | | | | | | |


status, comorbidities, and medication interactions.
| | | | |




12. Which type of research provides the highest level of evidence for clinical
| | | | | | | | | | |


decision-making?
|


A. Case series|


B. Randomized controlled trials (RCTs) | | |


C. Expert opinion |


D. Observational studies |




Answer: B |


Rationale: RCTs reduce bias and provide high-quality evidence for causality and
| | | | | | | | | |


effectiveness.
|




13. Which statement best describes shared decision-making in advanced
| | | | | | |


practice nursing?
| |


A. TheAPN makes decisions without patient input
| | | | | |


B. The patient makes all decisions independently
| | | | |


C. APN and patient collaborate, using evidence and patient values
| | | | | | | |


D. Family members dictate treatment plans
| | | |




Answer: C |


Rationale: Shared decision-making combines clinical evidence with patient
| | | | | | |


preferences and values.
| | |




14. AnAPN is treating a patient with early-stage heart failure. Which non-
| | | | | | | | | | |


pharmacologic intervention has strong evidence for improving outcomes?
| | | | | | | |


A. Daily high-sodium diet
| |


B. Structured exercise and fluid management | | | |


C. Complete bed rest | |


D. Ignoring weight monitoring | |




Answer: B |


Rationale: Exercise, fluid restriction, and daily weight monitoring are evidence-
| | | | | | | | |


based interventions for heart failure management.
| | | | | |




15. Which assessment tool is most appropriate for evaluating depression
| | | | | | | |


severity in adults?
| | |


A. MMSE
B. PHQ-9
C. GAD-7
D. Braden Scale |

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