NBME FORM 11 EXAM SCRIPT 2026
COMPREHENSIVE QUESTIONS AND
VERIFIED SOLUTIONS
⩥ Side effects of
rifampin
isoniazid
pyrazinamide. Answer: rifampin - hepatotox, cutaneous flushing
isoniazid - peripheral neuropathy with sideroblastic anemia, hepatox
pyrazinamide - hepatotox, hyperuricemia, arthralgias
⩥ Pt has apparent cirrhosis on exam with dullness to percussion over
flanks and distended abdomen. What is the most appropriate screening
test?. Answer: esophagogastroduodenoscopy
⩥ Young adult patient working in healthcare has a positive TB skin test
(15 mm). She is asymptomatic. She received the bCG vaccine during
infancy. What is your next step?. Answer: get a chest xray to exclude for
active TB
start on isoniazid therapy for latent TB
,bCG vaccine false-positive waves over 5 years
(15mm considered positive for healthy pt, 5mm positive for
immunocompromised)
to
⩥ What is a pleurodesis procedure. Answer: removes the pleural space
between the lung and the chest wall - done for pts with recurrent
malignant pleural effusions or recurrent pneumothoraces
⩥ What are lab values that support an empyema
pH
glucose
leukocyte count
appearance. Answer: ph less than 7.2
glucose less than 40
increased leukocytes
frank pus
⩥ What is the greatest risk factor for morbidity in a patient with a PE?.
Answer: age
, ⩥ bradypnea and miosis are specific indicators of what overdose?.
Answer: opioid
⩥ Pt has a central line for TPN and new onset fever and leukocytosis.
What is your next step in management>. Answer: blood cultures from
the catheter site (anaerobic and aerobic)
only resection the fistula via exploratory laparotomy if evidence of
peritonitis on exam
⩥ What is the difference between a case report and a case series?.
Answer: case report - describes disease course and outcome of a single
patient
case series - descriptive study that describes the history, possible
exposures, and clinical findings of a group of pts with a similar
diagnosis
⩥ Clinical findings of
anthrax
vaccinia
plague. Answer: anthrax - painless necrotic ulcer (cutnaeous anthrax)
COMPREHENSIVE QUESTIONS AND
VERIFIED SOLUTIONS
⩥ Side effects of
rifampin
isoniazid
pyrazinamide. Answer: rifampin - hepatotox, cutaneous flushing
isoniazid - peripheral neuropathy with sideroblastic anemia, hepatox
pyrazinamide - hepatotox, hyperuricemia, arthralgias
⩥ Pt has apparent cirrhosis on exam with dullness to percussion over
flanks and distended abdomen. What is the most appropriate screening
test?. Answer: esophagogastroduodenoscopy
⩥ Young adult patient working in healthcare has a positive TB skin test
(15 mm). She is asymptomatic. She received the bCG vaccine during
infancy. What is your next step?. Answer: get a chest xray to exclude for
active TB
start on isoniazid therapy for latent TB
,bCG vaccine false-positive waves over 5 years
(15mm considered positive for healthy pt, 5mm positive for
immunocompromised)
to
⩥ What is a pleurodesis procedure. Answer: removes the pleural space
between the lung and the chest wall - done for pts with recurrent
malignant pleural effusions or recurrent pneumothoraces
⩥ What are lab values that support an empyema
pH
glucose
leukocyte count
appearance. Answer: ph less than 7.2
glucose less than 40
increased leukocytes
frank pus
⩥ What is the greatest risk factor for morbidity in a patient with a PE?.
Answer: age
, ⩥ bradypnea and miosis are specific indicators of what overdose?.
Answer: opioid
⩥ Pt has a central line for TPN and new onset fever and leukocytosis.
What is your next step in management>. Answer: blood cultures from
the catheter site (anaerobic and aerobic)
only resection the fistula via exploratory laparotomy if evidence of
peritonitis on exam
⩥ What is the difference between a case report and a case series?.
Answer: case report - describes disease course and outcome of a single
patient
case series - descriptive study that describes the history, possible
exposures, and clinical findings of a group of pts with a similar
diagnosis
⩥ Clinical findings of
anthrax
vaccinia
plague. Answer: anthrax - painless necrotic ulcer (cutnaeous anthrax)
