Chemotherapy and Immunotherapy Exam Prep Guide
,create the 100 questions and answers well structured and well used right tick to mark correct
answer ONS Chemotherapy & Immunotherapy Certificate Exam (Latest 2025/2026) – A+ Graded
Hmm, this is a request for a large set of structured exam questions with answers. The user
wants 100 Q&A pairs for a chemotherapy/immunotherapy certification exam, formatted with
correct answers marked.
I need to ensure the questions cover key topics from the ONS curriculum while maintaining
accuracy. The response should be organized, clinically relevant, and include proper symbols for
correct answers.
I'll structure it with clear sections for different topics (safe handling, drug administration, side
effects, etc.), using a consistent format with bold numbering and checkmarks. The answers need
to be concise but comprehensive enough for exam preparation.
Since the user specified "latest 2025/2026," I'll include newer immunotherapy agents and
recent practice guidelines. The difficulty should match the ONS exam level—challenging but fair
for certified oncology nurses.
ONS Chemotherapy & Immunotherapy Certificate Exam (Latest 2025/2026) – 100 Practice
Questions & Answers
Section 1: Safe Handling, Administration, and Waste Management (1-25)
1. According to the ONS/ASCO standards for safe chemotherapy handling, which type of
personal protective equipment (PPE) is mandatory for nurses administering IV vesicants?
A. Single gloves
B. Single gloves and a face shield
C. Double gloves, a non-permeable gown, and eye/face protection ✓
D. A surgical mask
2. The primary purpose of using a closed-system transfer device (CSTD) is to:
A. Speed up the preparation process.
B. Protect healthcare workers from hazardous drug exposure by containing vapors and aerosols.
✓
C. Reduce the cost of chemotherapy drugs.
D. Eliminate the need for PPE during administration.
3. Which of the following is the correct sequence for donning PPE prior to drug
administration?
A. Gown, mask, goggles, gloves
,B. Gown, gloves, goggles, mask
C. Gown, goggles/mask, gloves ✓
D. Gloves, gown, goggles, mask
4. A patient receiving a continuous 5-FU infusion via a pump at home reports redness,
warmth, and pain at the IV site. Your first action should be to:
A. Increase the flow rate to flush the line.
B. Instruct the patient to stop the pump and disconnect the tubing. ✓
C. Tell the patient to apply a heating pad.
D. Advise the patient to take an aspirin.
5. The OSHA Hazard Communication Standard requires that all hazardous drugs (HDs):
A. Are administered only by physicians.
B. Have a Safety Data Sheet (SDS) readily available to employees. ✓
C. Are prepared under a Class II BSC only.
D. Are labeled with a blue sticker.
6. Which of the following items should be disposed of in a designated, leak-proof, puncture-
resistant chemotherapy waste container?
A. The patient's used food tray
B. Empty IV bags, tubing, gloves, and gowns used during administration ✓
C. Unused oral chemotherapy pills
D. The patient's bed linens
7. For how long should spill kits be available in all areas where HDs are handled?
A. Only during clinic hours
B. 24 hours a day, 7 days a week ✓
C. Only in the pharmacy
D. During the first cycle of a patient's treatment
8. When priming an IV tubing set with a hazardous drug, the nurse should:
A. Prime over a sink to facilitate cleanup.
B. Prime into a gauze pad inside a plastic bag or use a CSTD-priming feature. ✓
C. Prime the line at the patient's bedside.
D. Have the pharmacy pre-prime all tubing.
9. The maximum recommended time for a nurse to remain in a room where an aerosolized
drug like pentostatin is being administered is:
A. 15 minutes
B. 30 minutes
, C. 1 hour
D. There is no time limit; full PPE is sufficient. ✓
10. Which statement best describes the management of a minor (< 5 mL) spill of a hazardous
drug on the floor?
A. Evacuate the room and call housekeeping.
B. Don appropriate PPE, use the spill kit to contain and clean, and dispose of all materials as
hazardous waste. ✓
C. Cover it with a towel and notify the charge nurse.
D. Use a bleach solution to mop the area.
11. The "chemo double-check" process before administration involves verification by:
A. The prescribing physician only.
B. Two qualified clinicians at the point of care. ✓
C. The pharmacist and the patient.
D. A single nurse, as long as they are certified.
12. Which vein access site is generally contraindicated for the administration of vesicant
chemotherapy?
A. A large vein in the mid-forearm ✓
B. The dorsum of the hand
C. An antecubital fossa vein
D. A peripherally inserted central catheter (PICC)
13. Extravasation of a vesicant is suspected. After stopping the infusion, the next priority
action is to:
A. Apply warm compresses.
B. Attempt to aspirate any residual drug from the catheter. ✓
C. Administer the antidote.
D. Document the incident.
14. Which of the following is a key patient education point for safe handling of oral
chemotherapy at home?
A. Store pills in the bathroom medicine cabinet.
B. Crush or split pills to make them easier to swallow.
C. Wear disposable gloves when handling the medication. ✓
D. Flush unused pills down the toilet.
15. The most reliable method for confirming central venous access device (CVAD) tip
placement prior to administering vesicants is:
,create the 100 questions and answers well structured and well used right tick to mark correct
answer ONS Chemotherapy & Immunotherapy Certificate Exam (Latest 2025/2026) – A+ Graded
Hmm, this is a request for a large set of structured exam questions with answers. The user
wants 100 Q&A pairs for a chemotherapy/immunotherapy certification exam, formatted with
correct answers marked.
I need to ensure the questions cover key topics from the ONS curriculum while maintaining
accuracy. The response should be organized, clinically relevant, and include proper symbols for
correct answers.
I'll structure it with clear sections for different topics (safe handling, drug administration, side
effects, etc.), using a consistent format with bold numbering and checkmarks. The answers need
to be concise but comprehensive enough for exam preparation.
Since the user specified "latest 2025/2026," I'll include newer immunotherapy agents and
recent practice guidelines. The difficulty should match the ONS exam level—challenging but fair
for certified oncology nurses.
ONS Chemotherapy & Immunotherapy Certificate Exam (Latest 2025/2026) – 100 Practice
Questions & Answers
Section 1: Safe Handling, Administration, and Waste Management (1-25)
1. According to the ONS/ASCO standards for safe chemotherapy handling, which type of
personal protective equipment (PPE) is mandatory for nurses administering IV vesicants?
A. Single gloves
B. Single gloves and a face shield
C. Double gloves, a non-permeable gown, and eye/face protection ✓
D. A surgical mask
2. The primary purpose of using a closed-system transfer device (CSTD) is to:
A. Speed up the preparation process.
B. Protect healthcare workers from hazardous drug exposure by containing vapors and aerosols.
✓
C. Reduce the cost of chemotherapy drugs.
D. Eliminate the need for PPE during administration.
3. Which of the following is the correct sequence for donning PPE prior to drug
administration?
A. Gown, mask, goggles, gloves
,B. Gown, gloves, goggles, mask
C. Gown, goggles/mask, gloves ✓
D. Gloves, gown, goggles, mask
4. A patient receiving a continuous 5-FU infusion via a pump at home reports redness,
warmth, and pain at the IV site. Your first action should be to:
A. Increase the flow rate to flush the line.
B. Instruct the patient to stop the pump and disconnect the tubing. ✓
C. Tell the patient to apply a heating pad.
D. Advise the patient to take an aspirin.
5. The OSHA Hazard Communication Standard requires that all hazardous drugs (HDs):
A. Are administered only by physicians.
B. Have a Safety Data Sheet (SDS) readily available to employees. ✓
C. Are prepared under a Class II BSC only.
D. Are labeled with a blue sticker.
6. Which of the following items should be disposed of in a designated, leak-proof, puncture-
resistant chemotherapy waste container?
A. The patient's used food tray
B. Empty IV bags, tubing, gloves, and gowns used during administration ✓
C. Unused oral chemotherapy pills
D. The patient's bed linens
7. For how long should spill kits be available in all areas where HDs are handled?
A. Only during clinic hours
B. 24 hours a day, 7 days a week ✓
C. Only in the pharmacy
D. During the first cycle of a patient's treatment
8. When priming an IV tubing set with a hazardous drug, the nurse should:
A. Prime over a sink to facilitate cleanup.
B. Prime into a gauze pad inside a plastic bag or use a CSTD-priming feature. ✓
C. Prime the line at the patient's bedside.
D. Have the pharmacy pre-prime all tubing.
9. The maximum recommended time for a nurse to remain in a room where an aerosolized
drug like pentostatin is being administered is:
A. 15 minutes
B. 30 minutes
, C. 1 hour
D. There is no time limit; full PPE is sufficient. ✓
10. Which statement best describes the management of a minor (< 5 mL) spill of a hazardous
drug on the floor?
A. Evacuate the room and call housekeeping.
B. Don appropriate PPE, use the spill kit to contain and clean, and dispose of all materials as
hazardous waste. ✓
C. Cover it with a towel and notify the charge nurse.
D. Use a bleach solution to mop the area.
11. The "chemo double-check" process before administration involves verification by:
A. The prescribing physician only.
B. Two qualified clinicians at the point of care. ✓
C. The pharmacist and the patient.
D. A single nurse, as long as they are certified.
12. Which vein access site is generally contraindicated for the administration of vesicant
chemotherapy?
A. A large vein in the mid-forearm ✓
B. The dorsum of the hand
C. An antecubital fossa vein
D. A peripherally inserted central catheter (PICC)
13. Extravasation of a vesicant is suspected. After stopping the infusion, the next priority
action is to:
A. Apply warm compresses.
B. Attempt to aspirate any residual drug from the catheter. ✓
C. Administer the antidote.
D. Document the incident.
14. Which of the following is a key patient education point for safe handling of oral
chemotherapy at home?
A. Store pills in the bathroom medicine cabinet.
B. Crush or split pills to make them easier to swallow.
C. Wear disposable gloves when handling the medication. ✓
D. Flush unused pills down the toilet.
15. The most reliable method for confirming central venous access device (CVAD) tip
placement prior to administering vesicants is:
