Bio 207 Exam 2
et et et
Whatetisetmeantetbyettheettermet"restingetmembraneetpotential"?etHowetisetitetma
intained?et-etcorrectetanswer✔ ✔
RestingetmembraneetpotentialetisetwhenettheetequilibriumetpotentialetofetaetN
a+/K+etpumpetisetbetweenet-65etandet-85.et(-90mVetforetK+,et+60mVetforetNa+)
ItetisetmaintainedetbyettheetNa+/K+etpumpetbutetisetgeneratedetbyettheetunequalet
distributionetofetions.
Restingetmembraneetpotentialetisetcloseettoettheetequilibriumetpotentialetofetwhi
chetionet(EK+etoretENa+)?et-etcorrectetanswer✔ ✔
ItetisetmuchetcloserettoettheetK+etequilibriumet(-
90mV)etbecauseettheetmembraneetisetmoreetpermeableettoetK+
WhatetisettheetroleetofetNa+/K+etpumpetinetmaintainingetmembraneetpotential?et
Whatetisettheetroleetofetfixedetanions?et-etcorrectetanswer✔ ✔
TheetpumpsetactivelyetbringetinetK+,etwhichetpasseseteasilyetthroughettheetme
mbraneetandetmakesettheetcelletinterioretnegative
Negativeetanionsetinsideettheetcelletattractetcationsetoutsideettheetcell
Nameettheetsixettypesetofetglialetcellset-etcorrectetanswer✔ ✔
Schwannetcells
,Astrocytes
Microglia
Oligodendrocyte
Ependymal
Satelliteetcells
WhatetareettheetfunctionsetofetSchwannetcellsetinetnerveetconductionetandetnerve
etregenerationetfollowingetinjury? et-etcorrectetanswer✔ ✔
Schwannetcellsetformetmyelinetsheathsetaroundetperipheraletaxons.etMyelina
tedetaxonsetconductetimpulsesetmoreetrapidly.et
WhenetpartetofetaetPNSetnerveetisetsevered,ettheetSchwannetcelletsurvivesetandetf
ormsetaetregenerationettube.etTheettubeetreleasesetchemicalsetthatetattractetgrow
ingetaxonetandetguidesetregrowingetaxonettoetsynapticetsite.
Whatetareettheetfunctionsetofetoligodendrocytes?et-etcorrectetanswer✔ ✔
TheyetproduceetmyelinetsheathsetaroundetaxonsetinettheetCNS.etOneetoligode
ndrocyteetsendsetextensionsettoetseveraletaxons.
Whatetareettheetfunctionsetofetastrocytes?et-etcorrectetanswer✔ ✔
TakeetupetK+etfromettheetextracellularetenvironmentettoetmaintainetionicetenv
ironmentetforetneurons.etTakeetupetextraetneurotransmittersetreleasedetfrometax
onetendings;etTheetchemicalsetareetrecycled.etHelpetformettheetblood-
brainetbarrieretbyetproducingettightetjunctionsetinetbrainetcapillaries.etEnd-
, feetetaroundetcapillariesettakeetupetglucoseetfrometbloodetforetuseetbyetneuronsett
oetmakeetATP.
Describeetionetgatingetinetaxonset-etcorrectetanswer✔ ✔
Changesetinetmembraneetpotentialetareetcontrolledetbyetchangesetinettheetflow
etofetionsetthroughetionetchannels.
K+ethasettwoettypesetofetchannels:
Notetgatedet(alwaysetopen);etsometimesetcalledet"leaky"etK+etchannels
et
Voltage-
et
gatedetK+etchannels;etopenetwhenetaetparticularetmembraneetpotentialetisetreac
hed
Na+ethasetonlyetvoltage-gatedetchannelsetthatetareetclosedetatetrest.
TheetmembraneetisetlessetpermeableettoetNa+etatetrest.
Whatethappensetduringetactionetpotential?et-etcorrectetanswer✔ ✔
Whenetmembraneetpotentialetisetdepolarizedettoet-
55mV,etgatesetopenetthatetletetinetNa+.etNa+etpassesetthroughettheetmembraneeta
ndettheetmembraneetpotentialetthereforeetgetsetcloserettoettheetsodiumetpotential
.etAtet+30mV,ettheetsodiumetgatesetcloseetandettheetpotassiumetonesetopenettoetre
leaseetK+.etRepolarizationetgetsettheetrestingetpotentialetbacketdownettoet-
85mV,etwhereetitetisetthenetstabilizedetbyetNa+/K+etpumps.
et et et
Whatetisetmeantetbyettheettermet"restingetmembraneetpotential"?etHowetisetitetma
intained?et-etcorrectetanswer✔ ✔
RestingetmembraneetpotentialetisetwhenettheetequilibriumetpotentialetofetaetN
a+/K+etpumpetisetbetweenet-65etandet-85.et(-90mVetforetK+,et+60mVetforetNa+)
ItetisetmaintainedetbyettheetNa+/K+etpumpetbutetisetgeneratedetbyettheetunequalet
distributionetofetions.
Restingetmembraneetpotentialetisetcloseettoettheetequilibriumetpotentialetofetwhi
chetionet(EK+etoretENa+)?et-etcorrectetanswer✔ ✔
ItetisetmuchetcloserettoettheetK+etequilibriumet(-
90mV)etbecauseettheetmembraneetisetmoreetpermeableettoetK+
WhatetisettheetroleetofetNa+/K+etpumpetinetmaintainingetmembraneetpotential?et
Whatetisettheetroleetofetfixedetanions?et-etcorrectetanswer✔ ✔
TheetpumpsetactivelyetbringetinetK+,etwhichetpasseseteasilyetthroughettheetme
mbraneetandetmakesettheetcelletinterioretnegative
Negativeetanionsetinsideettheetcelletattractetcationsetoutsideettheetcell
Nameettheetsixettypesetofetglialetcellset-etcorrectetanswer✔ ✔
Schwannetcells
,Astrocytes
Microglia
Oligodendrocyte
Ependymal
Satelliteetcells
WhatetareettheetfunctionsetofetSchwannetcellsetinetnerveetconductionetandetnerve
etregenerationetfollowingetinjury? et-etcorrectetanswer✔ ✔
Schwannetcellsetformetmyelinetsheathsetaroundetperipheraletaxons.etMyelina
tedetaxonsetconductetimpulsesetmoreetrapidly.et
WhenetpartetofetaetPNSetnerveetisetsevered,ettheetSchwannetcelletsurvivesetandetf
ormsetaetregenerationettube.etTheettubeetreleasesetchemicalsetthatetattractetgrow
ingetaxonetandetguidesetregrowingetaxonettoetsynapticetsite.
Whatetareettheetfunctionsetofetoligodendrocytes?et-etcorrectetanswer✔ ✔
TheyetproduceetmyelinetsheathsetaroundetaxonsetinettheetCNS.etOneetoligode
ndrocyteetsendsetextensionsettoetseveraletaxons.
Whatetareettheetfunctionsetofetastrocytes?et-etcorrectetanswer✔ ✔
TakeetupetK+etfromettheetextracellularetenvironmentettoetmaintainetionicetenv
ironmentetforetneurons.etTakeetupetextraetneurotransmittersetreleasedetfrometax
onetendings;etTheetchemicalsetareetrecycled.etHelpetformettheetblood-
brainetbarrieretbyetproducingettightetjunctionsetinetbrainetcapillaries.etEnd-
, feetetaroundetcapillariesettakeetupetglucoseetfrometbloodetforetuseetbyetneuronsett
oetmakeetATP.
Describeetionetgatingetinetaxonset-etcorrectetanswer✔ ✔
Changesetinetmembraneetpotentialetareetcontrolledetbyetchangesetinettheetflow
etofetionsetthroughetionetchannels.
K+ethasettwoettypesetofetchannels:
Notetgatedet(alwaysetopen);etsometimesetcalledet"leaky"etK+etchannels
et
Voltage-
et
gatedetK+etchannels;etopenetwhenetaetparticularetmembraneetpotentialetisetreac
hed
Na+ethasetonlyetvoltage-gatedetchannelsetthatetareetclosedetatetrest.
TheetmembraneetisetlessetpermeableettoetNa+etatetrest.
Whatethappensetduringetactionetpotential?et-etcorrectetanswer✔ ✔
Whenetmembraneetpotentialetisetdepolarizedettoet-
55mV,etgatesetopenetthatetletetinetNa+.etNa+etpassesetthroughettheetmembraneeta
ndettheetmembraneetpotentialetthereforeetgetsetcloserettoettheetsodiumetpotential
.etAtet+30mV,ettheetsodiumetgatesetcloseetandettheetpotassiumetonesetopenettoetre
leaseetK+.etRepolarizationetgetsettheetrestingetpotentialetbacketdownettoet-
85mV,etwhereetitetisetthenetstabilizedetbyetNa+/K+etpumps.