NUR 3145 Exam 4 Questions with Correct Answers
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Terms in this set (147)
• A decrease in normal dopamine levels; the nerve
What happens in patients
cells that produce dopamine break down
with parkinson's?
• Progressively gets worse over time
Mask-like
blank expression
s&s of Parkinson's stooped posture
tremors
shuffling gait
What is the mechanism of increase levels of dopamine or antagonize effects of
action of parkinson's Ach
medications?
Indirect acting dopaminergic drugs
What are indirect acting
Dopamine Modulators
meds for parkinson?
COMT Inhibitor
Direct Acting meds for Direct acting dopamine receptor agonist
parkinson?
, indirect acting dopamine receptor agonists (MAO-B
inhibitor)
indirect acting inhibits the action of the enzyme monoamine oxidase
dopaminergic- Selegiline primary role of MAO is the breakdown of
(Zelapar) catecholamines (the catecholamines are pi, norepi
and dopamine)
prevents breakdown of lepadopa
can be used with carbidopa-levodopa
Selegiline (Zelapar) cannot be used with meperidine
interactions interaction with tyramine foods;(cheese; wine, beer ,
yogurt) produces severe hypertension
when is Selegiline early stage;adjunct drug for parkinsons
(Zelapar) used?
anti viral used in the early stage
nerve fibers release dopamine in the basal ganglia &
blocks the reuptake of dopamine reduces tremor and
dopamine modulator-
rigidity
amantadine (Symmetrel)
also used for influenza; effective for 6-8 months.
is a dopamine modulator
improves muscle control and reduces stiffness
dizziness, insomnia and nausea; this med has
adverse effects of
anticholinergic effects, if used with other
amantadine (Symmetrel)
anticholinergic meds will have additive effects
What are two types of talcapone (Tasmar)
COMT inhibitor? entacapone (Comtan)
adjunct drug to carbidopa-levodopa
COMT inhibitor-talcapone treats symptoms
(Tasmar) levodopa dose-sparing effect.
Works both centrally and peripherally
COMT inhibitor- adjunct; Works only peripherally, can not cross BBB
entacapone (Comtan)
Adverse effects of GI upset
talcapone or entacapone urine discoloration associated with severe liver failure
| Latest Update
Save
Terms in this set (147)
• A decrease in normal dopamine levels; the nerve
What happens in patients
cells that produce dopamine break down
with parkinson's?
• Progressively gets worse over time
Mask-like
blank expression
s&s of Parkinson's stooped posture
tremors
shuffling gait
What is the mechanism of increase levels of dopamine or antagonize effects of
action of parkinson's Ach
medications?
Indirect acting dopaminergic drugs
What are indirect acting
Dopamine Modulators
meds for parkinson?
COMT Inhibitor
Direct Acting meds for Direct acting dopamine receptor agonist
parkinson?
, indirect acting dopamine receptor agonists (MAO-B
inhibitor)
indirect acting inhibits the action of the enzyme monoamine oxidase
dopaminergic- Selegiline primary role of MAO is the breakdown of
(Zelapar) catecholamines (the catecholamines are pi, norepi
and dopamine)
prevents breakdown of lepadopa
can be used with carbidopa-levodopa
Selegiline (Zelapar) cannot be used with meperidine
interactions interaction with tyramine foods;(cheese; wine, beer ,
yogurt) produces severe hypertension
when is Selegiline early stage;adjunct drug for parkinsons
(Zelapar) used?
anti viral used in the early stage
nerve fibers release dopamine in the basal ganglia &
blocks the reuptake of dopamine reduces tremor and
dopamine modulator-
rigidity
amantadine (Symmetrel)
also used for influenza; effective for 6-8 months.
is a dopamine modulator
improves muscle control and reduces stiffness
dizziness, insomnia and nausea; this med has
adverse effects of
anticholinergic effects, if used with other
amantadine (Symmetrel)
anticholinergic meds will have additive effects
What are two types of talcapone (Tasmar)
COMT inhibitor? entacapone (Comtan)
adjunct drug to carbidopa-levodopa
COMT inhibitor-talcapone treats symptoms
(Tasmar) levodopa dose-sparing effect.
Works both centrally and peripherally
COMT inhibitor- adjunct; Works only peripherally, can not cross BBB
entacapone (Comtan)
Adverse effects of GI upset
talcapone or entacapone urine discoloration associated with severe liver failure
