Comprehensive Test Bank for ASCP BOC 2026 Exam
Preparation with 1400+ Real Exam Questions and Correct
Answers/ ASCP BOC Exam Prep Test Bank Latest 2026
1) The light-colored zone adjacent to the nucleus in a plasmacyte is the:
a. ribosome
b. chromatin
c. mitochondria
d. Golgi area - ANSWER-d (Morphological identifiable perinuclear halo.)
3) The majority of the iron in an adult is found as a constituent of:
a. hemoglobin
b. hemosiderin
c. myoglobin
d. transferrin - ANSWER-a (2/3 iron in body bound to Hgb.)
4) The main function of the hexose monophosphate shunt in the erythrocyte is to:
a. regulate the level of 2,3-DPG
b. provide reduced glutathione to prevent oxidation of hemoglobin
c. prevent the reduction of heme iron
d. provide energy for membrane maintenance - ANSWER-b (Maintains in Fe++
form by way of reduced glutathione.)
10) In order for hemoglobin to combine reversibly with oxygen, the iron must be:
a. complexed with haptoglobin
b. freely circulating in the cytoplasm
pg. 1
,c. attached to transferrin
d. in the ferrous state - ANSWER-d (Functional form of Fe [reduced].)
11) In which of the following disease states are teardrop cells and abnormal
platelets most characteristically seen?
a. hemolytic anemia
b. multiple myeloma
c. G-6-PD deficiency
d. myeloid metaplasia - ANSWER-d (RBC morphology; disease state
identification.)
13) In the normal adult, the spleen acts as a site for:
a. storage of RBCs
b. production of RBCs
c. synthesis of erythropoietin
d. removal of imperfect and aging cells - ANSWER-d (Major site of destruction of
senescent red blood cells.)
14) After the removal of RBCs from the circulation hemoglobin is broken down
into:
a. iron, prophyrin, amino acids
b. iron, protoporphyrin, globin
c. heme, protoporphyrin, amino acids
d. heme, hemosiderin, globin - ANSWER-b (Normal degradation products of red
blood cells.)
15) Heinz bodies are:
pg. 2
,a. readily identified with polychrome stains
b. rarely found in glucose-6-phosphate dehydrogenase deficient erythrocytes
c. closely associated with spherocytes
d. denatured hemoglobin inclusion that are readily removed by the spleen -
ANSWER-d (Formed with oxidization of Fe and formation of methemoglobin.)
17) Cells for the transport of O2 and CO2 are:
a. erythrocytes
b. granulocytes
c. lymphocytes
d. thrombocytes - ANSWER-a (Primary functions of red blood cells.)
18) Erythropoietin acts as:
a. shorten the replication time of the granulocytes
b. stimulate RNA synthesis of erythroid cells
c. increase colony-stimulating factors produced by the B-lymphs
d. decrease the release of marrow reticulocytes - ANSWER-b (Erythropoietin
action.)
19) What cell shape is most commonly associated with an increased MCHC?
a. teardrop cells
b. target cells
c. spherocytes
d. sickle cells - ANSWER-c (May be referred to as hyperchromic because of
decreased MCHC.)
pg. 3
, 27) Which of the following characteristics are common to hereditary spherocytosis,
hereditary elliptocytosis, hereditary stomatocytosis, and paroxysmal nocturnal
hemoglobinuria?
a. autosomal dominant inheritance
b. red cell membrane defect
c. positive DAT
d. measured platelet count - ANSWER-b (RBC membrane defects are common to
PNH, HS, and HE.)
30) Which of the following is most closely associated with iron deficiency anemia?
a. iron overload in tissue
b. target cells
c. basophilic stippling
d. chronic blood loss - ANSWER-d (Chronic blood loss frequently results in iron
deficiency anemia.)
32) Evidence indicates that the genetic defect in thalassemia usually results in:
a. the production of abnormal globin chains
b. a quantitative deficiency in RNA resulting in decreased globin chain production
c. a structural change in the heme portion of the hemoglobin
d. an abnormality in the alpha- or beta- chain binding or affinity - ANSWER-b
(Mechanism of genetic abnormality in thalassemia reduces globin chain
production.)
36) An enzyme deficiency associated with a moderate to severe hemolytic anemia
after the patient is exposed to certain drugs and characterized by red cell inclusions
formed by denatured hemoglobin is:
a. LD deficiency
pg. 4
Preparation with 1400+ Real Exam Questions and Correct
Answers/ ASCP BOC Exam Prep Test Bank Latest 2026
1) The light-colored zone adjacent to the nucleus in a plasmacyte is the:
a. ribosome
b. chromatin
c. mitochondria
d. Golgi area - ANSWER-d (Morphological identifiable perinuclear halo.)
3) The majority of the iron in an adult is found as a constituent of:
a. hemoglobin
b. hemosiderin
c. myoglobin
d. transferrin - ANSWER-a (2/3 iron in body bound to Hgb.)
4) The main function of the hexose monophosphate shunt in the erythrocyte is to:
a. regulate the level of 2,3-DPG
b. provide reduced glutathione to prevent oxidation of hemoglobin
c. prevent the reduction of heme iron
d. provide energy for membrane maintenance - ANSWER-b (Maintains in Fe++
form by way of reduced glutathione.)
10) In order for hemoglobin to combine reversibly with oxygen, the iron must be:
a. complexed with haptoglobin
b. freely circulating in the cytoplasm
pg. 1
,c. attached to transferrin
d. in the ferrous state - ANSWER-d (Functional form of Fe [reduced].)
11) In which of the following disease states are teardrop cells and abnormal
platelets most characteristically seen?
a. hemolytic anemia
b. multiple myeloma
c. G-6-PD deficiency
d. myeloid metaplasia - ANSWER-d (RBC morphology; disease state
identification.)
13) In the normal adult, the spleen acts as a site for:
a. storage of RBCs
b. production of RBCs
c. synthesis of erythropoietin
d. removal of imperfect and aging cells - ANSWER-d (Major site of destruction of
senescent red blood cells.)
14) After the removal of RBCs from the circulation hemoglobin is broken down
into:
a. iron, prophyrin, amino acids
b. iron, protoporphyrin, globin
c. heme, protoporphyrin, amino acids
d. heme, hemosiderin, globin - ANSWER-b (Normal degradation products of red
blood cells.)
15) Heinz bodies are:
pg. 2
,a. readily identified with polychrome stains
b. rarely found in glucose-6-phosphate dehydrogenase deficient erythrocytes
c. closely associated with spherocytes
d. denatured hemoglobin inclusion that are readily removed by the spleen -
ANSWER-d (Formed with oxidization of Fe and formation of methemoglobin.)
17) Cells for the transport of O2 and CO2 are:
a. erythrocytes
b. granulocytes
c. lymphocytes
d. thrombocytes - ANSWER-a (Primary functions of red blood cells.)
18) Erythropoietin acts as:
a. shorten the replication time of the granulocytes
b. stimulate RNA synthesis of erythroid cells
c. increase colony-stimulating factors produced by the B-lymphs
d. decrease the release of marrow reticulocytes - ANSWER-b (Erythropoietin
action.)
19) What cell shape is most commonly associated with an increased MCHC?
a. teardrop cells
b. target cells
c. spherocytes
d. sickle cells - ANSWER-c (May be referred to as hyperchromic because of
decreased MCHC.)
pg. 3
, 27) Which of the following characteristics are common to hereditary spherocytosis,
hereditary elliptocytosis, hereditary stomatocytosis, and paroxysmal nocturnal
hemoglobinuria?
a. autosomal dominant inheritance
b. red cell membrane defect
c. positive DAT
d. measured platelet count - ANSWER-b (RBC membrane defects are common to
PNH, HS, and HE.)
30) Which of the following is most closely associated with iron deficiency anemia?
a. iron overload in tissue
b. target cells
c. basophilic stippling
d. chronic blood loss - ANSWER-d (Chronic blood loss frequently results in iron
deficiency anemia.)
32) Evidence indicates that the genetic defect in thalassemia usually results in:
a. the production of abnormal globin chains
b. a quantitative deficiency in RNA resulting in decreased globin chain production
c. a structural change in the heme portion of the hemoglobin
d. an abnormality in the alpha- or beta- chain binding or affinity - ANSWER-b
(Mechanism of genetic abnormality in thalassemia reduces globin chain
production.)
36) An enzyme deficiency associated with a moderate to severe hemolytic anemia
after the patient is exposed to certain drugs and characterized by red cell inclusions
formed by denatured hemoglobin is:
a. LD deficiency
pg. 4
