VERIFIED QUESTIONS AND ANSWERS
[GUARANTEED A+]
Overview - ✔✔A multisystemic, granulomatous disorder that
characteristically produces lymphadenopathy, pulmonary infiltration, and
skeletal, liver, eye, or skin lesions
May be acute (usually resolves within 2 years) or chronic
Chronic, progressive sarcoidosis (uncommon) associated with pulmonary
fibrosis and progressive pulmonary disability
Overview-Pathophysiology - ✔✔An excessive inflammatory process
begins in the alveoli, bronchioles, and blood vessels of the lungs.
Monocyte-macrophages accumulate in the target tissue, where they induce
the inflammatory process.
CD4+ T-lymphocytes and sensitized immune cells form a ring around the
inflamed area.
©morren2025/2026.Year published 2025.
, Fibroblasts, mast cells, collagen fibers, and proteoglycans encase the
inflammatory and immune cells, causing granuloma formation and leading
to obstruction or restriction in the lungs.
Overview-Causes - ✔✔Exact cause unknown
Possible causes:
Hypersensitivity response to atypical mycobacteria, fungi, and pine pollen
Chemicals
T-cell abnormalities
Lymphokine production abnormalities
Hypersensitivity response to atypical mycobacteria, fungi, and pine pollen
Chemicals
T-cell abnormalities
Lymphokine production abnormalities
Overview-Incidence - ✔✔Sarcoidosis is most common in people ages 20
to 40, with a peak incidence in those ages 25 to 35.
©morren2025/2026.Year published 2025.