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What is an NSAID used for? - CORRECT ANSWERS ✔✔mild
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to moderate pain
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What are the NSAIDs we must know? - CORRECT
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ANSWERS ✔✔diclofenac |\ |\
aspirin |\
naproxen |\
ibuprofen |\
celecoxib
What is the different in mechanism of action between 1st
|\ |\ |\ |\ |\ |\ |\ |\ |\ |\
generation and 2nd generation NSAIDs? - CORRECT |\ |\ |\ |\ |\ |\ |\
ANSWERS ✔✔1st generation: inhibits both COX-1 and |\ |\ |\ |\ |\ |\ |\
COX-2 |\
2nd generation: inhibits COX-2 only
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General mechanism of action (MOA) for NSAIDs -
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CORRECT ANSWERS ✔✔- inhibits COX-1 and COX-2, which
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inhibits prostaglandin synthesis centrally and peripherally
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|\
- antipyretic
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- anti-inflammatory
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,- antihistamine
|\
General side effects of NSAIDs - CORRECT ANSWERS ✔✔-
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GI upset/bleeding
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- Renal Toxicity
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- Liver Effects (jaundice or hepatitis)
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- Hypertension/CVA/MI
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- Setven's Johnson Syndrome
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- Seizures
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- Headache
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- Nervousness
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General nursing considerations for NSAIDs - CORRECT
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ANSWERS ✔✔- take with food (specifically protein rich in
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order to coat) |\ |\ |\
- caution with cardiac patients or patients with high BP
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- caution for patients with bleeding risk (ex: if taking
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warfarin) |\
- monitor pain level
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- do not crush, may give liquid
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Additional MOA for aspirin - CORRECT ANSWERS ✔✔-
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Decrease platelet aggregation |\ |\
,Additional side effects (SE) for aspirin - CORRECT |\ |\ |\ |\ |\ |\ |\ |\
ANSWERS ✔✔A - abdominal pain & asthma trigger |\ |\ |\ |\ |\ |\ |\ |\
S - salicylism
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P - Peptic ulcer disease
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I - Intestinal bleeding
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R - Reye's Syndrome & respiratory distress (Laryngeal
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edema) |\
I - Itchy/rash
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N - noise (tinnitus)
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Additional desired outcome for aspirin - CORRECT |\ |\ |\ |\ |\ |\ |\
ANSWERS ✔✔Reduced clotting risk |\ |\ |\
What kind of route of administration is diclofenac given? -
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CORRECT ANSWERS ✔✔Topical - ex: Voltaren gel |\ |\ |\ |\ |\ |\ |\
- will be more localized so wont have the same side
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effects as other NSAIDs |\ |\ |\
Additional SE for diclofenac - CORRECT ANSWERS ✔✔- |\ |\ |\ |\ |\ |\ |\ |\
pruritus |\
- dry skin
|\ |\
, Additional nursing consideration for diclofenac - CORRECT
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ANSWERS ✔✔- Monitor skin integrity
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Specific use for diclofenac - CORRECT ANSWERS ✔✔Knee
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and back pain
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What is the 2nd generation NSAID we must know? -
|\ |\ |\ |\ |\ |\ |\ |\ |\ |\
CORRECT ANSWERS ✔✔celecoxib (Celebrex) |\ |\ |\
What is celecoxib's MOA? - CORRECT ANSWERS
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✔✔inhibits COX-2 |\
Additional SE for celecoxib - CORRECT ANSWERS ✔✔-
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lower GI risk (better for long-term use)
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- greater risk for MI
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What is an example of a non-opioid analgesic? - CORRECT
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ANSWERS ✔✔acetaminophen (Tylenol)
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What is the mechanism of action for acetaminophen? -
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CORRECT ANSWERS ✔✔Inhibits prostaglandin synthesis in
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the CNS (centrally)
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