University of Sussex (UOS)

This resource contains two complete, exam‑style essays written under timed conditions for the Cell Signalling & Therapeutics module (University of Sussex, Third Year). Essay 1 (HER2 breast cancer): Explains the HER2–Ras–Raf–MEK–ERK signalling cascade and how ERK activation in HER2‑positive breast cancer develops resistance to receptor‑targeted therapies. Discusses mechanisms such as receptor bypass, B‑Raf mutations, and PI3K/AKT activation. Evaluates therapeutic strategies inclu...

This resource contains two complete, exam‑ready essays written under timed conditions for the Immunology in Health & Disease module (University of Sussex, Third Year). Essay 1: Comparison of Type I and Type III hypersensitivity reactions with clinical case studies. Includes detailed analysis of two patients (Ava and Noah), with blood test results integrated in text form. Explains diagnostic reasoning, immunological mechanisms (IgE vs IgG, mast cells vs immune complexes), and clinical outcomes...

This comprehensive study resource covers Glioblastoma Multiforme (GBM) in detail, designed for Semester 5 medical/biotech students and anyone preparing for exams in oncology, neuroscience, or pathology. What’s inside: Complete lecture notes (Etiology, epidemiology, risk factors, glial cell types, WHO grading, molecular subtypes, signaling pathways, treatment options); Mechanistic depth (Clear explanations of temozolomide (TMZ) action, MGMT resistance, and DNA repair pathways); Targeted ther...

This document provides a comprehensive study resource on breast cancer and glioblastoma signaling, designed for semester-level coursework and exam preparation. It covers: Epidemiology & statistics (global and UK incidence/mortality); Risk factors (modifiable and non-modifiable); Diagnosis methods (clinical, imaging, histopathology).; Breast cancer subtypes (Luminal A/B, HER2+, triple-negative); Estrogen receptor biology (ERα activation, phosphorylation sites, signaling pathways); Therapies (end...

This document is a set of structured study notes summarizing the key concepts of cancer cell metabolism, focusing on how metabolic pathways are reprogrammed to support tumor growth and survival. The notes outline core cellular metabolic pathways (glycolysis, the TCA cycle, and oxidative phosphorylation) and contrast normal cellular metabolism with the altered metabolic phenotype observed in cancer cells. The notes also describe how oncogenes and tumor suppressor genes—including HIF-1, PI3K/...

This powerpoint has all the slides from the beginning of the module till the end, it is best used to study with chatgpt by putting it all in and letting the AI quiz you on them.

These notes offer a lecture‐by‐lecture deep dive into every topic of the module, weaving together core concepts, key findings and cutting‐edge research. They’re your one‐stop resource for Canvas quiz prep and crafting 500-word exam essays with confidence. Key Topics Covered Diagnosis, Epidemiology & Pharmacology • Definitions, DSM-5/ICD-11 vs. RDoC framework • Neuroanatomy, brain imaging, psychopharmacology (PK/PD) Risk Factors • Biopsychosocial model – genetic, environ...

This study pack contains lecture notes summarised to not only be succint but provide enough detail (both contextual and mechanistic) which are then assessed by the exam practice section. Whilst the exam practice session focuses solely on the lecture notes, difficult questions utilise knowledge obtained to dedicated textbooks or external sources. The black font shows my attempt at answering a question while the red font shows AI supported feedback, raising the answer from its achieved mark to a h...

This study pack contains lecture notes summarised to not only be succint but provide enough detail (both contextual and mechanistic) which are then assessed by the exam practice section. Whilst the exam practice session focuses solely on the lecture notes, difficult questions utilise knowledge obtained to dedicated textbooks or external sources. The black font shows my attempt at answering a question while the red font shows AI supported feedback, raising the answer from its achieved mark to a h...

This study pack begins with the lecture notes summarised to only be a summary of the important points from the lectures but also provided detailed understanding sourced from textbooks and the internet. Following, the exam practice section is divided for each lecture, where black fonts show my attempt and red fonts are corrections to my attempts. AI was used to ensure that my corrections not only make my answer as similar to a first class marking (focusing on detail but succint styles). These que...