kinase- linked receptor

exam quain :
Kinase-Linked receptor
↳ Describe

*
Key features/characteristic of enzyme -
or kinase-linked receptor superfamily

Binding of Ligand conformational transmitted transmembrane helix
change in receptor protein via
>
- -
·




intrinsic/associated .
carsade
>
- activation of an
enzyme >
- initiation of signaling
·
Mediate action of multiple growth factors , cytokine & hormones
play major roles in regulation of cell growth , proliferation
& differentiation

contain an intrinsic enzyme activity in their intracellular domain diverse super family of
associate > multi-subunit transmembrane
directly with an intracellular enzyme
.


protein complex either :




·
Focuse on
Type
1
family (Epidermal Growth factor Receptor)
·




regulator of critical cellular processes .
e
g
sell cycle control & cell migration , cell survival & metabolism

proliferation & differentiation .




initiation of
· contain intrinsic
tyrosine kinase domain - become active
upon ligand binding -



signalling cascades
key regulators of critical cellular process e.g proliferation & differentiation
cycle control cell survival s metabolism.
migration
cell & cell ,




of cell surface receptor that transduce signals to polypeptide & Protein
·

family
hormones & growth factors
↓ exam question Describe
:



basis for subclassification of kinate
enzyme
or
*
-




-
linked receptor


↳ Receptor Tyrosine Kinases e
g
.
IR , EGFR

-
contain intrinsic
tyrosin kinases
activity

↳ Receptor Serine/Threonine Kinases TGF-BR
eg
-
contain intrinsic serine/threonine kinases activity

↳ Tyrosine Kinase-Associated Receptor (Cytokine Receptor (
- Associate with protein that have tyrosine kinase activity
.




↳ Receptor Guanylyl Cyclones - ANPR

-
contain intrinsic cyclase activity

↳ Receptor Tyrotine Phosphatases