APHON /
Overview Exam Questions With Correct Answers
/ // // // // //
biotherapy //- /
/CORRECT /
/ANSWERS(S)✔✔modality /
/of /
/tx: /
/agents /
/that /
/resemble /
/body's /
/own /
/defense /
/and /
/surveillance /
/systems. /
/can /
/augment/modulate/restore /
/host's /
/immune /
/response, /
/direct /
/antitumor //activity, //other //biological //effects. //side //effects //typically //hypersensitivity //rx
immune /
/surveillance //- /
/CORRECT /
/ANSWERS(S)✔✔tumor /
/cells /
/express /
/abnormal /
/tumor //antigens //on //surface //that //can //be //recognized/destroyed //by //immune //system
,natural /
/killer //cells //- //CORRECT //ANSWERS(S)✔✔lymphocyte //that //recognizes/kills //malignant //cells
cytotoxic //t //cells //- //CORRECT //ANSWERS(S)✔✔recognize //tumor-
assosiated //antigens //and //kills //cells
interferons //- /
/CORRECT //ANSWERS(S)✔✔multiple //moa's //& //produced //w/ //recombinant //dna. //
protein /
/capable //of //protecting //other //cells //from //viral //infections //by //interfering //w/ //viral //replication.
family /
/of //glycoproteins //include: //antiviral, //antiproliferative, //potent //immunomodulatory //effects
cytokines //- /
/CORRECT /
/ANSWERS(S)✔✔products /
/of //immune //cells //to //enhance //cytotoxic //activity //of //cells //and //increase //immune //response
alpha-interferon //- //CORRECT //ANSWERS(S)✔✔leukocyte-
derived. /
/tx: /
/hairy /
/cell /
/leukemia, /
/melanoma, /
/chronic //myeloid //leukemia, //follicular //lymphoma, //multiple //myeloma, //cutaneous //t-
cell //lymphoma
beta-interferon //- //CORRECT //ANSWERS(S)✔✔fibroblast-derived. //tx //MS
gamma-interferon //- //CORRECT //ANSWERS(S)✔✔t-
lymphocyte //derived. //tx //chronic //granulomatus //disease
,interleukin-2 //- //CORRECT //ANSWERS(S)✔✔produced //by //t-
helper //cells //& //stimulate //growth/maturation //of //t-cell //subsets, //cytotoxic //t-cells, //production
//of //lymphokines //& //cytokines.
act //as //chemical //signals //b/w //wbc's //(revs //up //immune //system)
retinoids //- /
/CORRECT /
/ANSWERS(S)✔✔immunomodulators //that //facilitate //differentiation //& //suppress //proliferation
//of //cancer //cells
all-trans //retinoic //acid //(atra) //- //CORRECT //ANSWERS(S)✔✔tx: //aml, //aml //m3 //subtype, //apl
increase //maturation //of //promyelocytic //blasts //and //rapid //resolution //of //coagulopathy //r/t //tx.
isotretinoin //(accutane) //- //CORRECT //ANSWERS(S)✔✔retinoid //tx //neuroblastoma. //
have /
/antitumor /
/activity /
/unknown /
/moa. /
/TERATOGENIC. /
/male/female //pt //must //register //iPledge //(fetal //exposure). //can //also //affect //hearing //& //vision
antibodies //- //CORRECT //ANSWERS(S)✔✔proteins //produced //by //b-
lymphocytes. /
/part //of //humoral //immunity //of //adaptive //system. //includes //immunoglobulins //(igG, //igA, //igM,
//igE, //igD)
murine //- //CORRECT //ANSWERS(S)✔✔mouse-
derived /
/MoAbs. /
/pt //develops //human //antimouse //antibodies //creating //high //risk //of //hypersensitivity //rx
, end //in //-momab
Monoclonal /
/antibodies //- /
/CORRECT /
/ANSWERS(S)✔✔very /
/specific. //directed //against //single //antigenic //determinant //on //cell //surface //causing //antibody-
dependent /
/cellular /
/toxicity, //direct //cell //death, //elimination //of //antigen/target //cell //that //expresses //the //antigen
low //toxicity
-ximab //- //CORRECT //ANSWERS(S)✔✔moab //combo //of //human //& //mouse //antibodies
-
zumab //- /
/CORRECT /
/ANSWERS(S)✔✔moab /
/humanized, //small //part //of //mouse //antibody //fused //w/ //human //antibody
-umab //- //CORRECT //ANSWERS(S)✔✔fully //humanized //moabs
chimeric /
/moab //- /
/CORRECT /
/ANSWERS(S)✔✔murine //variable //& //human //constant //coupled //using //recombinant //dna
purpose //of //moabs //- //CORRECT //ANSWERS(S)✔✔attach //low-
dose /
/radioisotopes //to //image //residual //disease. //target //chemo, //radiation, //biotherapy //to //tumor
purge //autologous //bone //marrow //of //cancer //cells //before //transplant
Overview Exam Questions With Correct Answers
/ // // // // //
biotherapy //- /
/CORRECT /
/ANSWERS(S)✔✔modality /
/of /
/tx: /
/agents /
/that /
/resemble /
/body's /
/own /
/defense /
/and /
/surveillance /
/systems. /
/can /
/augment/modulate/restore /
/host's /
/immune /
/response, /
/direct /
/antitumor //activity, //other //biological //effects. //side //effects //typically //hypersensitivity //rx
immune /
/surveillance //- /
/CORRECT /
/ANSWERS(S)✔✔tumor /
/cells /
/express /
/abnormal /
/tumor //antigens //on //surface //that //can //be //recognized/destroyed //by //immune //system
,natural /
/killer //cells //- //CORRECT //ANSWERS(S)✔✔lymphocyte //that //recognizes/kills //malignant //cells
cytotoxic //t //cells //- //CORRECT //ANSWERS(S)✔✔recognize //tumor-
assosiated //antigens //and //kills //cells
interferons //- /
/CORRECT //ANSWERS(S)✔✔multiple //moa's //& //produced //w/ //recombinant //dna. //
protein /
/capable //of //protecting //other //cells //from //viral //infections //by //interfering //w/ //viral //replication.
family /
/of //glycoproteins //include: //antiviral, //antiproliferative, //potent //immunomodulatory //effects
cytokines //- /
/CORRECT /
/ANSWERS(S)✔✔products /
/of //immune //cells //to //enhance //cytotoxic //activity //of //cells //and //increase //immune //response
alpha-interferon //- //CORRECT //ANSWERS(S)✔✔leukocyte-
derived. /
/tx: /
/hairy /
/cell /
/leukemia, /
/melanoma, /
/chronic //myeloid //leukemia, //follicular //lymphoma, //multiple //myeloma, //cutaneous //t-
cell //lymphoma
beta-interferon //- //CORRECT //ANSWERS(S)✔✔fibroblast-derived. //tx //MS
gamma-interferon //- //CORRECT //ANSWERS(S)✔✔t-
lymphocyte //derived. //tx //chronic //granulomatus //disease
,interleukin-2 //- //CORRECT //ANSWERS(S)✔✔produced //by //t-
helper //cells //& //stimulate //growth/maturation //of //t-cell //subsets, //cytotoxic //t-cells, //production
//of //lymphokines //& //cytokines.
act //as //chemical //signals //b/w //wbc's //(revs //up //immune //system)
retinoids //- /
/CORRECT /
/ANSWERS(S)✔✔immunomodulators //that //facilitate //differentiation //& //suppress //proliferation
//of //cancer //cells
all-trans //retinoic //acid //(atra) //- //CORRECT //ANSWERS(S)✔✔tx: //aml, //aml //m3 //subtype, //apl
increase //maturation //of //promyelocytic //blasts //and //rapid //resolution //of //coagulopathy //r/t //tx.
isotretinoin //(accutane) //- //CORRECT //ANSWERS(S)✔✔retinoid //tx //neuroblastoma. //
have /
/antitumor /
/activity /
/unknown /
/moa. /
/TERATOGENIC. /
/male/female //pt //must //register //iPledge //(fetal //exposure). //can //also //affect //hearing //& //vision
antibodies //- //CORRECT //ANSWERS(S)✔✔proteins //produced //by //b-
lymphocytes. /
/part //of //humoral //immunity //of //adaptive //system. //includes //immunoglobulins //(igG, //igA, //igM,
//igE, //igD)
murine //- //CORRECT //ANSWERS(S)✔✔mouse-
derived /
/MoAbs. /
/pt //develops //human //antimouse //antibodies //creating //high //risk //of //hypersensitivity //rx
, end //in //-momab
Monoclonal /
/antibodies //- /
/CORRECT /
/ANSWERS(S)✔✔very /
/specific. //directed //against //single //antigenic //determinant //on //cell //surface //causing //antibody-
dependent /
/cellular /
/toxicity, //direct //cell //death, //elimination //of //antigen/target //cell //that //expresses //the //antigen
low //toxicity
-ximab //- //CORRECT //ANSWERS(S)✔✔moab //combo //of //human //& //mouse //antibodies
-
zumab //- /
/CORRECT /
/ANSWERS(S)✔✔moab /
/humanized, //small //part //of //mouse //antibody //fused //w/ //human //antibody
-umab //- //CORRECT //ANSWERS(S)✔✔fully //humanized //moabs
chimeric /
/moab //- /
/CORRECT /
/ANSWERS(S)✔✔murine //variable //& //human //constant //coupled //using //recombinant //dna
purpose //of //moabs //- //CORRECT //ANSWERS(S)✔✔attach //low-
dose /
/radioisotopes //to //image //residual //disease. //target //chemo, //radiation, //biotherapy //to //tumor
purge //autologous //bone //marrow //of //cancer //cells //before //transplant
