NU 578
NU 578 Controlled Substances Unit 2 | Questions And
Answers | 2025-2026 Update | 100% Guaranteed Pass –
University Of South Alabama
Methadone C/I C/I
, Tapentadol A/E Hydromorphone C/i
2 of 86
Term
When to NOT give Morphine:
elderly/young (monitor)
Hx of Resp disease (COPD/Asthma)
Concurrent with CNS depressant
RR less than 12
REVERSE WITH NARCAN
Parenteral: induction and
maintenance of surgical
anesthesia.
Transdermal: severe
persistent pain in the opioid
tolerant
Biliary Colic
o Induce spasm of the common bile duct, causing pressure w/in the biliary tract to
rise dramatically
Symptoms epigastric distress to biliary colic
, Interacts with numerous drugs
LT use results in
accumulation of dangerous
metabolite
Interact with MAOI
Do not use in seizure d/o
3 of 86
Definition
Preexisting hx of prolonged
QT intervals or other drugs
that prolong. I. regular EKG
and >500msec stop
Avoid CNS depressants
Avoid drugs that inhibit
CYP3A4 ex clarithryomycin,
antifungal drugs, and HIV
protease inhibitors
methadone C/I morphine C/i
hydromorphone C/i methadone S/e
, 4 of 86
Definition
Full opioid agonists
Mod-strong Opioid
agonist.
Oxycodone is metabolized
by CYP3A4; therefore, drugs
that induce or inhibit
CYP3A4 can alter
oxycodone levels
*Do not crush*
oxycodone methadone
morphine hydrocodone
5 of 86
Term
Remifentanil drug class
NU 578 Controlled Substances Unit 2 | Questions And
Answers | 2025-2026 Update | 100% Guaranteed Pass –
University Of South Alabama
Methadone C/I C/I
, Tapentadol A/E Hydromorphone C/i
2 of 86
Term
When to NOT give Morphine:
elderly/young (monitor)
Hx of Resp disease (COPD/Asthma)
Concurrent with CNS depressant
RR less than 12
REVERSE WITH NARCAN
Parenteral: induction and
maintenance of surgical
anesthesia.
Transdermal: severe
persistent pain in the opioid
tolerant
Biliary Colic
o Induce spasm of the common bile duct, causing pressure w/in the biliary tract to
rise dramatically
Symptoms epigastric distress to biliary colic
, Interacts with numerous drugs
LT use results in
accumulation of dangerous
metabolite
Interact with MAOI
Do not use in seizure d/o
3 of 86
Definition
Preexisting hx of prolonged
QT intervals or other drugs
that prolong. I. regular EKG
and >500msec stop
Avoid CNS depressants
Avoid drugs that inhibit
CYP3A4 ex clarithryomycin,
antifungal drugs, and HIV
protease inhibitors
methadone C/I morphine C/i
hydromorphone C/i methadone S/e
, 4 of 86
Definition
Full opioid agonists
Mod-strong Opioid
agonist.
Oxycodone is metabolized
by CYP3A4; therefore, drugs
that induce or inhibit
CYP3A4 can alter
oxycodone levels
*Do not crush*
oxycodone methadone
morphine hydrocodone
5 of 86
Term
Remifentanil drug class
