Sedation & Anesthesia Pharmacology
Mastery Exam: 150 Questions,
Answers And Rationales
2025/2026
1. Which drug is commonly used for rapid sequence intubation due to
its fast onset?
A. Midazolam
B. Propofol
C. Etomidate
D. Diazepam
Etomidate has rapid onset and minimal cardiovascular effects, making
it ideal for RSI.
2. Which inhaled anesthetic has the fastest induction time?
A. Halothane
B. Isoflurane
C. Sevoflurane
D. Desflurane
Desflurane has a very low blood-gas solubility, leading to rapid onset.
3. Which sedative is a benzodiazepine?
A. Dexmedetomidine
B. Ketamine
C. Midazolam
D. Propofol
Midazolam is a short-acting benzodiazepine used for procedural
sedation.
,4. Which drug provides dissociative anesthesia?
A. Propofol
B. Ketamine
C. Thiopental
D. Fentanyl
Ketamine produces dissociative anesthesia and preserves airway
reflexes.
5. Which opioid is commonly used with anesthesia for analgesia?
A. Morphine
B. Fentanyl
C. Codeine
D. Tramadol
Fentanyl is a potent, short-acting opioid commonly used in anesthesia.
6. Which neuromuscular blocker is depolarizing?
A. Rocuronium
B. Vecuronium
C. Pancuronium
D. Succinylcholine
Succinylcholine depolarizes the neuromuscular junction to cause
paralysis.
7. Which agent is used to reverse benzodiazepine effects?
A. Naloxone
B. Flumazenil
C. Neostigmine
D. Sugammadex
Flumazenil is a benzodiazepine antagonist.
8. Which agent reverses opioid overdose?
A. Flumazenil
B. Naloxone
, C. Atropine
D. Physostigmine
Naloxone competitively antagonizes opioid receptors.
9. Which IV anesthetic causes significant hypotension?
A. Ketamine
B. Etomidate
C. Propofol
D. Midazolam
Propofol causes vasodilation and myocardial depression.
10. Which local anesthetic is most cardiotoxic if overdosed?
A. Lidocaine
B. Procaine
C. Bupivacaine
D. Chloroprocaine
Bupivacaine has high cardiotoxic potential at toxic doses.
Questions 11–50
11. Which inhaled anesthetic can trigger malignant
hyperthermia?
A. Nitrous oxide
B. Halothane
C. Sevoflurane
D. Xenon
Volatile anesthetics like halothane can trigger malignant
hyperthermia.
12. What drug treats malignant hyperthermia?
A. Diazepam
B. Dantrolene
Mastery Exam: 150 Questions,
Answers And Rationales
2025/2026
1. Which drug is commonly used for rapid sequence intubation due to
its fast onset?
A. Midazolam
B. Propofol
C. Etomidate
D. Diazepam
Etomidate has rapid onset and minimal cardiovascular effects, making
it ideal for RSI.
2. Which inhaled anesthetic has the fastest induction time?
A. Halothane
B. Isoflurane
C. Sevoflurane
D. Desflurane
Desflurane has a very low blood-gas solubility, leading to rapid onset.
3. Which sedative is a benzodiazepine?
A. Dexmedetomidine
B. Ketamine
C. Midazolam
D. Propofol
Midazolam is a short-acting benzodiazepine used for procedural
sedation.
,4. Which drug provides dissociative anesthesia?
A. Propofol
B. Ketamine
C. Thiopental
D. Fentanyl
Ketamine produces dissociative anesthesia and preserves airway
reflexes.
5. Which opioid is commonly used with anesthesia for analgesia?
A. Morphine
B. Fentanyl
C. Codeine
D. Tramadol
Fentanyl is a potent, short-acting opioid commonly used in anesthesia.
6. Which neuromuscular blocker is depolarizing?
A. Rocuronium
B. Vecuronium
C. Pancuronium
D. Succinylcholine
Succinylcholine depolarizes the neuromuscular junction to cause
paralysis.
7. Which agent is used to reverse benzodiazepine effects?
A. Naloxone
B. Flumazenil
C. Neostigmine
D. Sugammadex
Flumazenil is a benzodiazepine antagonist.
8. Which agent reverses opioid overdose?
A. Flumazenil
B. Naloxone
, C. Atropine
D. Physostigmine
Naloxone competitively antagonizes opioid receptors.
9. Which IV anesthetic causes significant hypotension?
A. Ketamine
B. Etomidate
C. Propofol
D. Midazolam
Propofol causes vasodilation and myocardial depression.
10. Which local anesthetic is most cardiotoxic if overdosed?
A. Lidocaine
B. Procaine
C. Bupivacaine
D. Chloroprocaine
Bupivacaine has high cardiotoxic potential at toxic doses.
Questions 11–50
11. Which inhaled anesthetic can trigger malignant
hyperthermia?
A. Nitrous oxide
B. Halothane
C. Sevoflurane
D. Xenon
Volatile anesthetics like halothane can trigger malignant
hyperthermia.
12. What drug treats malignant hyperthermia?
A. Diazepam
B. Dantrolene
