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ATI Capstone Exam 2 2025: Verified Practice Questions & Key Content Review

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Prepare for the ATI Capstone Comprehensive Assessment 2 with our accurate 2025 guide. Features verified practice questions covering Management of Care, Pharmacology, Adult & Maternal-Child Health, Mental Health, and Fundamentals to boost your readiness for the proctored exam.

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2025/2026
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1|Page



ATI Capstone Exam 2 Newest 2025 with
accurate and verified questions covering key
nursing content areas including medical-surgical,
pharmacology, mental health, maternal-
newborn, and community health nursing for
comprehensive NCLEX preparation.




An immunizing agent that confers active immunity
protects by: - .....ANSWER ...✔✔ providing antibodies
obtained from immune humans or animals.


Antacids should be given one hour apart from most
other drugs. Which is the rationale? - .....ANSWER
...✔✔ Antacids may interfere with absorption of
drugs taken at the same time.


Vancomycin should not be used to treat minor infections
because it: - .....ANSWER ...✔✔ can cause "red man
syndrome", a hypertensive crisis that is almost always
fatal.

,2|Page



The antagonist for a client who has overdosed on
morphine is: - .....ANSWER ...✔✔ narcan.


The most serious adverse reaction to oral contraceptives
is: - .....ANSWER ...✔✔ thromboembolism.


When a client develops tolerance to a drug, the nurse
would expect: - .....ANSWER ...✔✔ higher dose
needed to achieve same effect.


Antihyperglycemic agents are prescribed for clients
with: - .....ANSWER ...✔✔ Type 2 diabetes mellitus.


The nurse assesses a client shortly after an intravenous
infusion of the osmotic diuretic mannitol is started. Which
finding represents an early adverse effect of mannitol? -
.....ANSWER ...✔✔ Bounding pulse


Compared to other beta adrenergic blockers,
cardioselective beta adrenergic blockers: - .....ANSWER
...✔✔ are less likely to cause bronchoconstriction.


A client who experiences motion sickness during airplane
flights obtains a prescription for meclizine (Antivert).

,3|Page



When is the best time to take the drug? - .....ANSWER
...✔✔ One hour before the flight


Before prescribing a cephalosporin, the nurse
practitioner asks if the client is allergic to penicillin. Why
is this important to assess? - .....ANSWER ...✔✔ A
client who is allergic to penicillin can have a cross
sensitivity to cephalosporins.


The use of which class of antibiotics should be avoided in
children? - .....ANSWER ...✔✔ Tetracyclines


In a walk-in clinic, clients are often given intramuscular
injections. Which drug should be readily available in
case a client has an anaphylactic reaction? -
.....ANSWER ...✔✔ Epinephrine


Thiazide and loop (high ceiling) diuretics are similar in
that both: - .....ANSWER ...✔✔ decrease tubular
reabsorption of sodium and water.


Which of the statements by the nurse most accurately
describes the effects of declined plasma albumin levels
in older adults? - .....ANSWER ...✔✔ "There is an
increased risk for adverse effects."

, 4|Page




To prevent oral fungal infections, the nurse should
instruct the client who uses a beclomethasone inhaler to
take which action? - .....ANSWER ...✔✔ Rinse the
mouth after each use.


A client takes ethinyl estradiol/norgestimate (Ortho Tri-
Cyclen) birth control pills. She calls the clinic and relates
that she missed her medication yesterday. Which
instructions will the nurse give? - .....ANSWER ...✔✔
"Take two pills today then continue on a daily basis."


The nurse may administer acetylcysteine (Mucomyst)
inhalation to: - .....ANSWER ...✔✔ facilitate mucus
expectoration.


Development of a chronic cough is an adverse effect
associated with which class of anti-hypertensive drugs? -
.....ANSWER ...✔✔ Angiotensin converting enzyme
(ACE) inhibitors


The nurse may administer baclofen (Lioresal) for the
treatment of which condition? - .....ANSWER ...✔✔
Protracted muscle spasticity
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