PCB 3233 Exam 5 Questions and Answers
Latest 2025 Top Rated A+
How many complement receptors are there?
4
-CR1,CR2,CR3,CR4
CR1 binds to
C3b
CR3 and CR4 binds to?
iC3b and LPS
CR2 binds to?
C3D
CD19 is the?
signalling component.
What does BCR & BCR co-receptor provide?
It provides a stronger signal.
The Co-receptors can bind on which two kinds of
antigens?
Membrane bound antigens and Soluble antigen
Mature Dendritic Cells are known as what for T-cells?
Reservoir of antigen for T-cells
B-cells can get their antigen from
-Subcapsular Macrophages
-Follicular dendritic cells
B-cells and T-cells are both activated in
,Secondary lymphoid tissue, where harbored antigens are
located.
What chemokine draws T-cells to Mature Debdritic
Cells?
CCL18
What chemokine draws B-cells into the follicle?
CXCL13 draws the B-cell to the dendritic cell and binds on
receptor CXCR5 on B-cell.
Mature Dendritic cells are also known as
Interdigitating Reticular cells
Surface marker for Mature Dendritic cells
DC-SIGN
Surface marker for immature dendritic cells
DEC205
AID
-changes "c's" to "u's" in DNA
-used in Somatic Hypermutation and Isotype Switching
In the Primary Follicle B-cells...
-form Germinal centers
-proceeds into Somatic Hypermutation and Isotype
switching
In the Medullary Cords B-cells...
Can become Plasma cells and secrete IgM
CD40 and CD40L leads to
Isotype Switching and Somatic Hypermutation
Centroblasts
, -Dark Zone
-Somatic Hypermutation
-Isotype Switching
-Proliferation
*NO BCR ON SURFACE
Centrocytes
-Expresses BCR again to test against antigen
-Testing new receptor to make sure they have higher
affinity
-little to no proliferation
Somatic Hypermutation changes what?
CDRs
Isotype Switching changes what?
Fc regions of Heavy regions
Which B-cell will be able to gain access and
outcompete all of the other B-cells?
The one with the highest Affinity
What helps B-cells go through Somatic hypermutation
and Isotype Switching?
AID
True or False? Centrocytes would be highly
proliferating B-cells.
False
Latest 2025 Top Rated A+
How many complement receptors are there?
4
-CR1,CR2,CR3,CR4
CR1 binds to
C3b
CR3 and CR4 binds to?
iC3b and LPS
CR2 binds to?
C3D
CD19 is the?
signalling component.
What does BCR & BCR co-receptor provide?
It provides a stronger signal.
The Co-receptors can bind on which two kinds of
antigens?
Membrane bound antigens and Soluble antigen
Mature Dendritic Cells are known as what for T-cells?
Reservoir of antigen for T-cells
B-cells can get their antigen from
-Subcapsular Macrophages
-Follicular dendritic cells
B-cells and T-cells are both activated in
,Secondary lymphoid tissue, where harbored antigens are
located.
What chemokine draws T-cells to Mature Debdritic
Cells?
CCL18
What chemokine draws B-cells into the follicle?
CXCL13 draws the B-cell to the dendritic cell and binds on
receptor CXCR5 on B-cell.
Mature Dendritic cells are also known as
Interdigitating Reticular cells
Surface marker for Mature Dendritic cells
DC-SIGN
Surface marker for immature dendritic cells
DEC205
AID
-changes "c's" to "u's" in DNA
-used in Somatic Hypermutation and Isotype Switching
In the Primary Follicle B-cells...
-form Germinal centers
-proceeds into Somatic Hypermutation and Isotype
switching
In the Medullary Cords B-cells...
Can become Plasma cells and secrete IgM
CD40 and CD40L leads to
Isotype Switching and Somatic Hypermutation
Centroblasts
, -Dark Zone
-Somatic Hypermutation
-Isotype Switching
-Proliferation
*NO BCR ON SURFACE
Centrocytes
-Expresses BCR again to test against antigen
-Testing new receptor to make sure they have higher
affinity
-little to no proliferation
Somatic Hypermutation changes what?
CDRs
Isotype Switching changes what?
Fc regions of Heavy regions
Which B-cell will be able to gain access and
outcompete all of the other B-cells?
The one with the highest Affinity
What helps B-cells go through Somatic hypermutation
and Isotype Switching?
AID
True or False? Centrocytes would be highly
proliferating B-cells.
False
