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Version 3 – HESI & NGN Pharmacology Practice Exam | 100 Original Questions with Rationales 2025/2026

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Master pharmacology concepts with Version 3 of the HESI and NGN Pharmacology Practice Exam. This 100-question exam includes fully original questions and detailed rationales, covering drug classes, mechanisms of action, side effects, nursing considerations, and therapeutic uses. Designed for nursing students preparing for HESI RN, Next Generation NCLEX (NGN), and NCLEX-RN exams. Updated for 2025/2026 to ensure the most current and relevant content.

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HESI + NGN PHARMACOLOGY
Course
HESI + NGN PHARMACOLOGY











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Institution
HESI + NGN PHARMACOLOGY
Course
HESI + NGN PHARMACOLOGY

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Uploaded on
November 29, 2025
Number of pages
48
Written in
2025/2026
Type
Exam (elaborations)
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VERSION 3 — HESI + NGN PHARMACOLOGY PRACTICE EXAM (100
ORIGINAL QUESTIONS + RATIONALES)
PART I — NGN-STYLE CASE STUDIES (25 QUESTIONS)
===============================
📘 CASE STUDY 1 — HEART FAILURE EXACERBATION (Questions
1–5)


Patient: 72-year-old with acute HF.
Meds: Furosemide IV, carvedilol, lisinopril, potassium chloride.


1. (Matrix: Match drug → expected effect)


Drugs:


Furosemide


Carvedilol


Lisinopril


Potassium chloride


Effects:


Decrease preload


Lower potassium loss

,VERSION 3 — HESI + NGN PHARMACOLOGY PRACTICE EXAM (100
ORIGINAL QUESTIONS + RATIONALES)


Reduce HR/BP


Vasodilation


Answer:


Furosemide → Decrease preload


Carvedilol → Reduce HR/BP


Lisinopril → Vasodilation


Potassium → Lower potassium loss


Rationale: Furosemide removes fluid; carvedilol lowers workload;
ACE inhibitors dilate vessels; potassium replaces losses.


2. (Multiple-response)


Which findings indicate furosemide is too effective?


A. BP 82/48
B. Weight ↓ 2 lbs overnight
C. Potassium 3.0

,VERSION 3 — HESI + NGN PHARMACOLOGY PRACTICE EXAM (100
ORIGINAL QUESTIONS + RATIONALES)
D. Crackles improved
E. Urine output 2000 mL


Answer: A, C
Rationale: Hypotension + hypokalemia require immediate
correction.


3. (Cloze)


Before giving carvedilol, the nurse must check the patient’s
______.


Answer: Heart rate
Rationale: Hold if HR <60.


4.


Which symptom is an ACE inhibitor adverse effect?


A. Dry cough
B. Bradycardia
C. Chest pain
D. Constipation


Answer: A

, VERSION 3 — HESI + NGN PHARMACOLOGY PRACTICE EXAM (100
ORIGINAL QUESTIONS + RATIONALES)
5. (Priority)


Which finding requires first action?


A. 1+ edema
B. Sodium 138
C. Potassium 2.9
D. HR 64


Answer: C
Rationale: Life-threatening arrhythmias possible.


📘 CASE STUDY 2 — COMMUNITY-ACQUIRED PNEUMONIA
(Questions 6–10)


Patient: 55-year-old on IV ceftriaxone, albuterol PRN,
acetaminophen.


6. (Matrix: Expected vs Unexpected)


Findings:


WBC 7,200


Rash

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