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Chapter 28 Review Questions Study Guide | High-Yield Exam Prep, Advanced Concepts, & Verified Knowledge Check

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Strengthen your mastery of Chapter 28 with this academically engineered Review Questions Study Guide, designed for learners who demand high-level conceptual clarity and exam-focused reinforcement. Whether used for course review, test prep, or intensive revision, this resource delivers a structured, high-yield approach that transforms complex concepts into clear, exam-ready understanding.

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Uploaded on
November 22, 2025
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C. Decreased erythrocytes in the circulating blood Correct

Anemia is a reduction in the total number of erythrocytes in the circulating
1. Which statement is a description blood or a decrease in the quality or quantity of hemoglobin. This option is
for the term anemia? the only one that accurately describes anemia.

A. Increased white blood cell size
B. Increased erythrocyte number in
the circulating blood
C. Decreased erythrocytes in the
circulating blood
D. Decreased circulating platelets




D. Presence of megaloblasts Correct

The macrocytic anemias are characterized by unusually large stem cells
(megaloblasts) in the marrow that mature into unusually large cells
2. Which characteristic describes (macrocytes) in the circulation. These cells have increased size, thickness,
macrocytic anemia? and volume. These anemias are the result of defective erythrocyte
deoxyribonucleic acid (DNA) synthesis, which is commonly caused by
A. Small cell size deficiencies of vitamin B12 (cobalamin) or folate (folic acid) or defective
B. Decreased thickness coenzymes that are required for nuclear maturation and DNA synthesis.
C. Caused by increased folate
D. Presence of megaloblasts

, B. It is associated with end-stage type A chronic atrophic gastritis. Correct

3. Regarding pernicious anemia,
which is a true statement? Pernicious anemia is the most common type of megaloblastic anemia and is
caused by vitamin B12 deficiency, which is often associated with the end-
A. It is a rare form of megaloblastic stage type A chronic atrophic (congenital or autoimmune) gastritis. It
anemia. generally occurs in older adults with a mean age of onset of 60 years.
B. It is associated with end-stage type
A chronic atrophic gastritis.
C. It has a viral origin.
D. It has a mean age of onset of 6
years.



C. Sideroblastic Correct

4. A defect in mitochondrial heme
Sideroblastic anemias are a heterogeneous group of disorders characterized
synthesis causes which form of
by varying severity because of a deviation in mitochondrial heme synthesis.
anemia?
Iron deficiency anemia is the most common type of anemia worldwide and
is a type of microcytic-hypochromic anemia. Unusually large erythrocytes
A. Iron deficiency
(macrocytes) characterize megaloblastic anemias.
B. Microcytic-hypochromic
C. Sideroblastic
D. Megaloblastic



A. Aplastic anemia Correct

Aplastic anemia occurs with pancytopenia, which is a decrease in all three
5. What is the term for a reduction in cell types. Hereditary hemochromatosis (HH) is a common inherited,
red blood cells, white blood cells, and autosomal recessive disorder of iron metabolism and is characterized by
platelets? increased gastrointestinal iron absorption with subsequent tissue iron.
Myelodysplastic syndrome is a group of disorders that demonstrate
hematopoietic stem cell dysfunction. A defect of mitochondrial heme
A. Aplastic anemia Correct synthesis causes sideroblastic anemia.
B. Hereditary hemochromatosis
C. Myelodysplastic syndrome
D. Sideroblastic anemia

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