MCB 4271 FINAL EXAM QUESTIONS AND CORRECT ANSWERS. VERIFIED 2025/2026.

MCB 4271 FINAL EXAM QUESTIONS
AND CORRECT ANSWERS. VERIFIED
2025/2026.




DNA Disrupt - ANS Metronidazole


DNA gyrase - ANS Quinolones target type II topoisomerases (DNA synth gyrase and topo IV)
Novobiocin


tRNA - ANS Mupirocin


RNA Polymerase - ANS Rifamycin
Erythromycin (Anasamycins)


Protein Synth: 50s - ANS Lincosanides
Macrolides
Chlorophenicol
Oxazolidinones (cycloserine)
Streptogramins


Protein synth: 30s - ANS aminoglycosides
tetracyclines


1 @COPYRIGHT 2025/2026 ALLRIGHTS RESERVED.

, Folic Acid Synthesis Inhibitors - ANS Sulfonamides- DHP synthesis
Trimethoprim- DHPR


Cell wall synthesis inhibitors - ANS Beta-lactams (PCN, cephalosporin, carbapenems,
monobactames, clavams)
glycopeptides (vanco)


Peptidoglycan synth: Cycloserine, bacitracin


Cell Membrane Function Inhibitor - ANS Antibacterial: polymixin, daptomycin
Antifungal: Amphoterian B, Nystatin, Terbinafine, Azoles


AMR mechanisms Mutations - ANS Rifampicin- point mut in rpoB coding for beta subunit or
RNA polymerase
Fluoroquinolones- mut in QRDR of GyrA & ParC/GrlA
Trimethoprim- mut in chromosome gene DHFR


AMR Mechanisms Horizontal Gene Transfer - ANS Methicillin- acq MecA gene by MRSA
Sulfonamide- acq foreign folP gene
Vanco- acq vanA& vanB gene


AMR Mechanisms - ANS PCN- inactivated by betalactamases, abx efflux pumps on G-
Cephalosporin- same as PCN
Carbapenems- resist hydrolysis by beta lactamases


viral integrase inhibitors - ANS Drugs that inhibit the action of the HIV integrase, so that the
virus cannot integrate into the host cell genome.
- usese: genetic inj, membrane fusion, endocytosis

2 @COPYRIGHT 2025/2026 ALLRIGHTS RESERVED.