MIDTERM EXAM NR507: NR507 ADVANCED
PATHOPHYSIOLOGY, 2025/2026 WITH
CORRECT/ACCURATE ANSWERS
NEWEST/BRAD NEW
AT CHAMBERLAIN UNIVERSITY
KEY TOPICS TYPICALLY INCLUDE:
Cardiovascular conditions
Hematologic disorders
Pulmonary functions:
, Renal and urological disorders
Endocrine system alterations
Neurological and psychological disorders
Immunology
ADVANCED PATHOPHYSIOLOGY
1. A common cause of urinary calculi that form due to accumulation
and bacterial destruction is:
A. Calcium phosphate stones
B. Struvite stones
C. Cystine stones
D. Uric acid stones
Rationale: Uric acid stones commonly form in acidic urine and can result from purine
metabolism issues.
2. An “innocent small fraction of 1%” of cells capable of self-
renewal and differentiation refers to:
A. Somatic cells
B. Stem cells
C. Gametes
D. Platelets
Rationale: Stem cells comprise a tiny cellular population with the ability to
differentiate.
3. The process in which renal cells undergo programmed division is
called:
A. Apoptosis
B. Necrosis
C. Cell cycle
D. Mitosis only
Rationale: The cell cycle encompasses all stages of cell division.
4. Anaphylaxis is which type of hypersensitivity reaction?
, A. Type II
B. Type I
C. Type III
D. Type IV
Rationale: Type I is IgE-mediated, rapid, and life-threatening.
5. Type II cytotoxic hypersensitivity reactions are primarily
mediated by:
A. IgA
B. IgE
C. IgM or IgG
D. Complement alone
Rationale: Type II involves IgM or IgG binding to cell surfaces leading to lysis.
6. A consequence of Rh incompatibility is:
A. T-cell suppression
B. Complement-mediated RBC lysis
C. IgA deficiency
D. Autoimmune thyroiditis
Rationale: Maternal antibodies attack fetal RBCs → hemolysis.
7. Cold exposure followed by warm/humid exposure triggering
systemic reaction refers to:
A. Type II hypersensitivity
B. Autoimmunity
C. Anaphylaxis
D. Serum sickness
Rationale: A rapid shift in environmental conditions can trigger anaphylactic
responses in sensitized individuals.
8. A primary immunodeficiency example is:
A. Diabetes
B. HIV
C. Chronic Granulomatous Disease
D. Malnutrition
Rationale: CGD is a congenital, genetic immune disorder.
PATHOPHYSIOLOGY, 2025/2026 WITH
CORRECT/ACCURATE ANSWERS
NEWEST/BRAD NEW
AT CHAMBERLAIN UNIVERSITY
KEY TOPICS TYPICALLY INCLUDE:
Cardiovascular conditions
Hematologic disorders
Pulmonary functions:
, Renal and urological disorders
Endocrine system alterations
Neurological and psychological disorders
Immunology
ADVANCED PATHOPHYSIOLOGY
1. A common cause of urinary calculi that form due to accumulation
and bacterial destruction is:
A. Calcium phosphate stones
B. Struvite stones
C. Cystine stones
D. Uric acid stones
Rationale: Uric acid stones commonly form in acidic urine and can result from purine
metabolism issues.
2. An “innocent small fraction of 1%” of cells capable of self-
renewal and differentiation refers to:
A. Somatic cells
B. Stem cells
C. Gametes
D. Platelets
Rationale: Stem cells comprise a tiny cellular population with the ability to
differentiate.
3. The process in which renal cells undergo programmed division is
called:
A. Apoptosis
B. Necrosis
C. Cell cycle
D. Mitosis only
Rationale: The cell cycle encompasses all stages of cell division.
4. Anaphylaxis is which type of hypersensitivity reaction?
, A. Type II
B. Type I
C. Type III
D. Type IV
Rationale: Type I is IgE-mediated, rapid, and life-threatening.
5. Type II cytotoxic hypersensitivity reactions are primarily
mediated by:
A. IgA
B. IgE
C. IgM or IgG
D. Complement alone
Rationale: Type II involves IgM or IgG binding to cell surfaces leading to lysis.
6. A consequence of Rh incompatibility is:
A. T-cell suppression
B. Complement-mediated RBC lysis
C. IgA deficiency
D. Autoimmune thyroiditis
Rationale: Maternal antibodies attack fetal RBCs → hemolysis.
7. Cold exposure followed by warm/humid exposure triggering
systemic reaction refers to:
A. Type II hypersensitivity
B. Autoimmunity
C. Anaphylaxis
D. Serum sickness
Rationale: A rapid shift in environmental conditions can trigger anaphylactic
responses in sensitized individuals.
8. A primary immunodeficiency example is:
A. Diabetes
B. HIV
C. Chronic Granulomatous Disease
D. Malnutrition
Rationale: CGD is a congenital, genetic immune disorder.
