Test Bank - Cellular and Molecular Immunology, 10th Edition (Abbas, 2022), Chapter 1-21 | All Chapters

TEST BANK p4




Cellular and Molecular Immunology
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Abul Abbas, Andrew Lichtman, and Shiv Pillai
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10th Edition
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,Table of Contents
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Chapter 01 Properties and Overview of Immune Responses
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Chapter 02 Cells and Tissues of the Immune System
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Chapter 03 Leukocyte Circulation and Migration Into Tissues
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Chapter 04 Innate Immunity
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Chapter 05 Antibodies and Antigens
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Chapter 06 Antigen Presentation to T Lymphocytes and the Functions of Major
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Histocompatibility Complex Molecules p4 p4 20
Chapter 07 Immune Receptors and Signal Transduction
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Chapter 08 Lymphocyte Development and Antigen Receptor Gene Rearrangement
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Chapter 09 Activation of T Lymphocytes
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Chapter 10 Differentiation and Functions of CD4+ Effector T Cells
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Chapter 11 Differentiation and Functions of CD8+ Effector T Cells
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Chapter 12 B Cell Activation and Antibody Production
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Chapter 13 Effector Mechanisms of Humoral Immunity
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Chapter 14 Specialized Immunity at Epithelial Barriers and in Immune Privileged Tissues
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Chapter 15 Immunologic Tolerance and Autoimmunity
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Chapter 16 Immunity to Microbes
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Chapter 17 Transplantation Immunology
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Chapter 18 Tumor Immunology
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Chapter 19 Hypersensitivity Disorders
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Chapter 20 Allergy
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Chapter 21 Primary and Acquired Immunodeficiencies
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,Chapter 01: Properties and Overview of Immune Responses
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Abbas, Lichtman, and Pillai: Cellular and Molecular Immunology, 10th Edition
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MULTIPLE CHOICE p4




1. The principal function of the immune system is:
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a. Defense against cancer p4 p4



b. Repair of injured tissues p4 p4 p4



c. Defense against microbial infections p4 p4 p4



d. Prevention of inflammatory diseases p4 p4 p4



e. Protection against environmental toxins p4 p4 p4




ANS: C p 4



The immune system has evolved in the setting of selective pressures imposed by
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microbial infections. Although immune responses to cancer may occur, the concept that
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“immunosurveillance” against cancer is a principal function of the immune system is
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controversial. Repair of injured tissues may be a secondary consequence of the immune
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responses and inflammation. Although the immune system has regulatory features that
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are needed to prevent excessive inflammation, prevention of inflammatory diseases is
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not a primary function. The immune system can protect against microbial toxins, but it
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generally does not offer protection against toxins of nonbiologic origin.
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2. Which of the following infectious diseases was prevented by the first successful
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vaccination?
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a. Polio
b. Tuberculosis
c. Smallpox
d. Tetanus
e. Rubella
ANS: C p 4



In 1798, Edward Jenner reported the first intentional successful vaccination, which was
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against smallpox in a boy, using material from the cowpox pustules of a milkmaid. In
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1980, smallpox was reported to be eradicated worldwide by a vaccination program.
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Effective vaccines against tetanus toxin, rubella virus, and poliovirus were developed in
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the 20th century and are widely used. There is no effective vaccine against
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Mycobacterium tuberculosis.
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3. Which of the following is a unique property of the adaptive immune system?
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a. Highly diverse repertoire of specificities for antigens
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b. Self-nonself discrimination p4



c. Recognition of microbial structures by both cell-associated and soluble receptors p4 p4 p4 p4 p4 p4 p4 p4 p4



d. Protection against viral infections p4 p4 p4



e. Responses that have the same kinetics and magnitude on repeated exposure to the
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same microbe p4 p4




ANS: p 4 A

, Highly diverse repertoires of specificities for antigens are found only in T and B
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lymphocytes, which are the central cellular components of the adaptive immune system.
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Both the innate and the adaptive immune systems use cell-associated and soluble receptors
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to recognize microbes, display some degree of self-nonself discrimination, and protect
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against viruses. On repeated exposure to the same microbe, the adaptive immune
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response becomes more rapid and of greater magnitude; this is the manifestation of
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memory.
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4. Antibodies and T lymphocytes are the respective mediators of which two types of
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immunity?
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a. Innate and adaptive p4 p4



b. Passive and active p4 p4



c. Specific and nonspecific p4 p4



d. Humoral and cell-mediated p4 p4



e. Adult and neonatal p4 p4




ANS: D p 4



Both B and T lymphocytes are principal components of adaptive immunity. B
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lymphocytes produce antibodies, which are the recognition and effector molecules of
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humoral immune responses to extracellular pathogens. T cells recognize and promote
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eradication of intracellular pathogens in cell-mediated immunity. Passive and active
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immunity both can be mediated by either B or T lymphocytes. Specific immunity is
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another term for adaptive immunity. Both B and T lymphocytes participate in adult
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adaptive immunity but are still developing in the neonatal period.
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5. The two major functional classes of effector T lymphocytes are:
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a. Helper T lymphocytes and cytotoxic T lymphocytes p4 p4 p4 p4 p4 p4




b. Natural killer cells and cytoWtoWxW
ic.TTlB
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c. Memory T cells and effector T cells p4 p4 p4 p4 p4 p4



d. Helper cells and antigen-presenting cells p4 p4 p4 p4



e. Cytotoxic T lymphocytes and target cells p4 p4 p4 p4 p4




ANS: A p 4



T cells can be classified into effector subsets that perform different effector functions. Most
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effector T cells are either helper T lymphocytes, which enhance the responses of other
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immune cells, including phagocytes and B cells, to infections, or cytotoxic T
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lymphocytes, which directly kill infected cells. Natural killer cells are not T
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lymphocytes.
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Antigen-presenting cells usually are not T cells. Memory T cells are not effector T cells. p4 p4 p4 p4 p4 p4 p4 p4 p4 p4 p4 p4 p4 p4




6. Which of the following cell types is required for all adaptive humoral immune responses?
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a. Natural killer cells p4 p4



b. Dendritic cells p4



c. Cytolytic T lymphocytes p4 p4



d. B lymphocytes p4



e. Helper T lymphocytes p4 p4




ANS: D p 4



Humoral immune responses are antibody-mediated immune responses, and all antibodies
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are made by B lymphocytes and no other cell type.
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