SAMENVATTING
FARMACEUTISCHE BIOLOGIE
Tweede semester 2020
, Inhoud
1. Inleiding ................................................................................................................................................... 4
1. Begripsbepaling .................................................................................................................................. 4
2. Primaire VS secundair metabolisme ................................................................................................... 4
3. Aanrijking van actieve bestanddelen .................................................................................................. 5
2. Fenylpropaan derivaten .......................................................................................................................... 7
1. Fenylpropaanderivaten (C6C3) ............................................................................................................ 8
1. In Harsen......................................................................................................................................... 8
2. In vluchtige oliën ............................................................................................................................ 9
2. Cumarinen ............................................................................................................................................... 9
1. Simpele Cumarinen ........................................................................................................................ 9
2. Furanocumarinen ......................................................................................................................... 10
3. Pyranocumarinen ......................................................................................................................... 11
4. Lignanen............................................................................................................................................ 11
5. C6C2-, C6C- en C6-afbouwproducten .................................................................................................. 12
3. Acetogeninen ........................................................................................................................................ 13
1. Vetzuren en derivaten ...................................................................................................................... 13
1. Prostanoïden ................................................................................................................................ 14
2. Vetten en oliën ............................................................................................................................. 15
3. Wassen ......................................................................................................................................... 17
2. Polyketiden ....................................................................................................................................... 18
1. Antranoïden .................................................................................................................................. 19
2. Andere verbindingen .................................................................................................................... 21
3. SHZ/ACG-combinatiederivaten ......................................................................................................... 21
1. C6C3/ lineaire nC2 verbindingen .................................................................................................... 21
2. C6C3 / cyclische nC2 verbindingen ................................................................................................. 21
4. Glycanen .................................................................................................................................................... 23
1. Bouwstenen ...................................................................................................................................... 23
1. Monosacchariden ......................................................................................................................... 23
2. Disaccharide ................................................................................................................................. 24
2. Structuur................................................................................................................................................ 24
3. Functies in organismen ..................................................................................................................... 24
4. Biosynthese....................................................................................................................................... 25
, 1. Principe A (vooral reservekoolhydraten)...................................................................................... 25
2. Principe B ...................................................................................................................................... 25
5. Homoglycanen (homopolysacchariden) ........................................................................................... 25
1. Homoglucanen.............................................................................................................................. 25
2. Homogalactanen .......................................................................................................................... 26
6. Heteroglycanen................................................................................................................................. 27
1. Guluronomanuronanen ................................................................................................................ 27
2. Heteroxylanen .............................................................................................................................. 27
3. Galactomannanen ........................................................................................................................ 28
5. Alkaloïden .................................................................................................................................................. 29
1. Fenylalanine derivaten ..................................................................................................................... 29
1. Arylalkylaminen ............................................................................................................................ 30
2. Simpele TH isochinolinen.............................................................................................................. 31
3. Benzyl TH isochinolinen ................................................................................................................ 32
4. TH isochinoline-monoterpenen .................................................................................................... 34
5. Tropolonen ................................................................................................................................... 35
2. Tryptofaan derivaten............................................................................................................................. 35
1. Indool alkaloïden .......................................................................................................................... 36
2. Chinoline alkaloïden ..................................................................................................................... 39
3. Lysine/Ornithine derivaten ............................................................................................................... 40
1. Piperidine/chinolizidine alkaloïden .............................................................................................. 40
2. Pyrrolidine alkaloïden ................................................................................................................... 41
4. Alkaloïden afkomstig van andere aminozuren ...................................................................................... 42
6. Terpenoïden en Steroïden..................................................................................................................... 43
1. Monoterpenen.................................................................................................................................. 44
1. In vluchtige oliën .......................................................................................................................... 44
2. Onregelmatige monoterpenen ..................................................................................................... 46
3. Iridoïden ....................................................................................................................................... 46
2. Sesquiterpenen ................................................................................................................................. 46
3. Diterpenen ........................................................................................................................................ 47
4. Triterpenen ....................................................................................................................................... 49
5. Tetraterpenen ................................................................................................................................... 50
6. Steroïden........................................................................................................................................... 50
, 1. Steroïdale saponinen .................................................................................................................... 51
2. Hartglycosiden .............................................................................................................................. 51
FARMACEUTISCHE BIOLOGIE
Tweede semester 2020
, Inhoud
1. Inleiding ................................................................................................................................................... 4
1. Begripsbepaling .................................................................................................................................. 4
2. Primaire VS secundair metabolisme ................................................................................................... 4
3. Aanrijking van actieve bestanddelen .................................................................................................. 5
2. Fenylpropaan derivaten .......................................................................................................................... 7
1. Fenylpropaanderivaten (C6C3) ............................................................................................................ 8
1. In Harsen......................................................................................................................................... 8
2. In vluchtige oliën ............................................................................................................................ 9
2. Cumarinen ............................................................................................................................................... 9
1. Simpele Cumarinen ........................................................................................................................ 9
2. Furanocumarinen ......................................................................................................................... 10
3. Pyranocumarinen ......................................................................................................................... 11
4. Lignanen............................................................................................................................................ 11
5. C6C2-, C6C- en C6-afbouwproducten .................................................................................................. 12
3. Acetogeninen ........................................................................................................................................ 13
1. Vetzuren en derivaten ...................................................................................................................... 13
1. Prostanoïden ................................................................................................................................ 14
2. Vetten en oliën ............................................................................................................................. 15
3. Wassen ......................................................................................................................................... 17
2. Polyketiden ....................................................................................................................................... 18
1. Antranoïden .................................................................................................................................. 19
2. Andere verbindingen .................................................................................................................... 21
3. SHZ/ACG-combinatiederivaten ......................................................................................................... 21
1. C6C3/ lineaire nC2 verbindingen .................................................................................................... 21
2. C6C3 / cyclische nC2 verbindingen ................................................................................................. 21
4. Glycanen .................................................................................................................................................... 23
1. Bouwstenen ...................................................................................................................................... 23
1. Monosacchariden ......................................................................................................................... 23
2. Disaccharide ................................................................................................................................. 24
2. Structuur................................................................................................................................................ 24
3. Functies in organismen ..................................................................................................................... 24
4. Biosynthese....................................................................................................................................... 25
, 1. Principe A (vooral reservekoolhydraten)...................................................................................... 25
2. Principe B ...................................................................................................................................... 25
5. Homoglycanen (homopolysacchariden) ........................................................................................... 25
1. Homoglucanen.............................................................................................................................. 25
2. Homogalactanen .......................................................................................................................... 26
6. Heteroglycanen................................................................................................................................. 27
1. Guluronomanuronanen ................................................................................................................ 27
2. Heteroxylanen .............................................................................................................................. 27
3. Galactomannanen ........................................................................................................................ 28
5. Alkaloïden .................................................................................................................................................. 29
1. Fenylalanine derivaten ..................................................................................................................... 29
1. Arylalkylaminen ............................................................................................................................ 30
2. Simpele TH isochinolinen.............................................................................................................. 31
3. Benzyl TH isochinolinen ................................................................................................................ 32
4. TH isochinoline-monoterpenen .................................................................................................... 34
5. Tropolonen ................................................................................................................................... 35
2. Tryptofaan derivaten............................................................................................................................. 35
1. Indool alkaloïden .......................................................................................................................... 36
2. Chinoline alkaloïden ..................................................................................................................... 39
3. Lysine/Ornithine derivaten ............................................................................................................... 40
1. Piperidine/chinolizidine alkaloïden .............................................................................................. 40
2. Pyrrolidine alkaloïden ................................................................................................................... 41
4. Alkaloïden afkomstig van andere aminozuren ...................................................................................... 42
6. Terpenoïden en Steroïden..................................................................................................................... 43
1. Monoterpenen.................................................................................................................................. 44
1. In vluchtige oliën .......................................................................................................................... 44
2. Onregelmatige monoterpenen ..................................................................................................... 46
3. Iridoïden ....................................................................................................................................... 46
2. Sesquiterpenen ................................................................................................................................. 46
3. Diterpenen ........................................................................................................................................ 47
4. Triterpenen ....................................................................................................................................... 49
5. Tetraterpenen ................................................................................................................................... 50
6. Steroïden........................................................................................................................................... 50
, 1. Steroïdale saponinen .................................................................................................................... 51
2. Hartglycosiden .............................................................................................................................. 51
