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This@study@source@was@downloaded@by@100000826342158@@on@09-15-2021@17:54:15@GMT@-
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,https://www.stuvia.com/
Chapter 1 RBCs and Platelet Preservation: Historical Perspectives and Current Trends
@ @ @ @ @ @ @ @ @ @
Multiple Choice
@
Identify the choice that best completes the statement or answers the question.
@ @ @ @ @ @ @ @ @ @ @
1. Which metabolic pathway is responsible for generating 90% of the ATP for the RBC?
@ @ @ @ @ @ @ @ @ @ @ @ @
a. Pentose phosphate shunt c. Glycolysis
@ @
b. Luebering-Rapoport shunt d. Methemoglobin reductase @ @ @
2. A unit of blood was returned to the blood bank before it was spiked. Apparently the patient’s IV failed.
@ @ @ @ @ @ @ @ @ @ @ @ @ @ @ @ @ @ @
The unit of blood was outside the blood bank for 35 minutes. Which of the statements below is most a
@ @ @ @ @ @ @ @ @ @ @ @ @ @ @ @ @ @ @
ccurate?
a. The unit of blood should be discarded immediately.
@ @ @ @ @ @ @
b. The unit of blood can be returned to inventory.
@ @ @ @ @ @ @ @
c. The unit of blood must be transfused within 4 hours or be discarded at the end of that time.
@ @ @ @ @ @ @ @ @ @ @ @ @ @ @ @ @ @
d. The unit of blood must be transfused with 24 hours.
@ @ @ @ @ @ @ @ @
3. What is the average diameter of a platelet?
@ @ @ @ @ @ @
a. 5 to 10 µm @ @ @ c. 1 to 2 µm @ @ @
b. 2 to 4 µm @ @ @ d. 4 to 6 µm
@ @ @ @ @
4. In the normal hemoglobin-
@ @ @
oxygen dissociation curve, what percentage of oxygen is released to the tissues when PO2 averages 4
@ @ @ @ @ @ @ @ @ @ @ @ @ @ @
0 mm Hg? @ @
a. 75% c. 100%
b. 25% d. 50% @
5. What factors are known to influence platelet metabolism and function?
@ @ @ @ @ @ @ @ @
a. Storage temperature c. Platelet count
@ @
b. Initial pH d. All of the above
@ @ @ @ @
6. Which of the following red blood cell morphologies may be present on the peripheral blood smear as a re
@ @ @ @ @ @ @ @ @ @ @ @ @ @ @ @ @ @
sult of loss of RBC membrane?
@ @ @ @ @
a. Spherocytes c. Burr cells @
b. Target cells d. Schistocytes
@ @
7. What does the term autologous transfusion refer to?
@ @ @ @ @ @ @
a. A parent donating blood for his or her child
@ @ @ @ @ @ @ @
b. An individual donating blood for a friend
@ @ @ @ @ @
c. An individual donating blood for a relative
@ @ @ @ @ @
d. An individual donating blood for his or her own transfusion
@ @ @ @ @ @ @ @ @
8. What is the primary function of hemoglobin?
@ @ @ @ @ @
a. Iron metabolism @ c. Oxygen transport @
b. Porphyrin synthesis d. Signal transduction
@ @ @
9. All of the following areas of red blood cell biology are crucial for normal erythrocyte survival except:
@ @ @ @ @ @ @ @ @ @ @ @ @ @ @ @
a. Cellular metabolism. c. Site of the ABO antigen attachment.
@ @ @ @ @ @
b. RBC membrane. @ d. Hemoglobin structure. @ @
This@study@source@was@downloaded@by@100000826342158@@on@09-15-2021@17:54:15@GMT@-
05:00
https://www.coursehero.com/file/25537437/ch01rtf/
,https://www.stuvia.com/
@ 10. What is the correct biochemical composition of the RBC membrane?
@ @ @ @ @ @ @ @ @ @
a. 52% protein, 40% lipid, 8% carbohydrate
@ @ @ @ @
b. 40% protein, 8% lipid, 52% carbohydrate
@ @ @ @ @
c. 8% protein, 52% lipid, 40% carbohydrate
@ @ @ @ @
d. 8% lipid, 40% carbohydrate, 52% protein
@ @ @ @ @
@ 11. All of the following biochemical changes are associated with loss of red blood cell viability upon storage
@ @ @ @ @ @ @ @ @ @ @ @ @ @ @ @ @
except:
a. Decreased pH. c. Increased ATP level.
@ @ @
b. Loss of red blood cell function.
@ @ d. Decreased glucose consumption.
@ @ @ @ @ @
@ 12. Which red blood cell preservative has a storage time of 35 days?
@ @ @ @ @ @ @ @ @ @ @ @
a. ACD c. AS-1
b. CPDA-1 d. CPD @ @
@ 13. The RBC membrane is relatively permeable to all of the following except:
@ @ @ @ @ @ @ @ @ @ @ @
a. Chloride. c. Bicarbonate.
b. Sodium. d. Water. @
@ 14. What percentage of platelets is sequestered in the spleen as functional reserve after being released from
@ @ @ @ @ @ @ @ @ @ @ @ @ @ @ @
the bone marrow?
@ @ @
a. 30% c. 10%
b. 50% d. 25% @ @
@ 15. What is the major biochemical consideration in platelet storage?
@ @ @ @ @ @ @ @ @
a. Glucose metabolism @ c. Production of carbon dioxide @ @ @
b. Oxygen supply @ d. Regulation of pH @ @ @
@ 16. What would the hemoglobin-
@ @ @ @
oxygen dissociation curve depict in a patient exhibiting clinical signs of alkalosis?
@ @ @ @ @ @ @ @ @ @ @
a. Normal c. Shift to the right @ @ @
b. Shift to the left @ @ d. None of the above
@ @ @ @ @
@ 17. Name the main lipid components of a red blood cell membrane.
@ @ @ @ @ @ @ @ @ @ @
a. Phospholipid c. Glycolipid
b. Sphingomyelin d. Glycophorin A @ @
@ 18. The ABO blood groups were discovered in 1901 by whom?
@ @ @ @ @ @ @ @ @ @
a. Charles Drew @c. Loutit and Mollison @ @
b. Karl Landsteiner @ d. Edward Lindeman @ @
@ 19. A standing order of platelets was shipped to your facility by your supplier. It was inadvertently left in th
@ @ @ @ @ @ @ @ @ @ @ @ @ @ @ @ @ @ @
e corner of the department until discovered 36 hours later. What would the appropriate action be for the
@ @ @ @ @ @ @ @ @ @ @ @ @ @ @ @ @ @
blood banker? @
a. If the temperature in the box was 22 +/-
@ @ @ @ @ @ @ @
2°C and the platelet swirl seemed OK, it would be OK to accept the unit into inventor
@ @ @ @ @ @ @ @ @ @ @ @ @ @ @ @ @
y.
b. The platelets have fallen outside the supplier’s quality assurance. The unit should be
@ @ @ @ @ @ @ @ @ @ @ @ @
discarded because the pH has probably dropped too low and platelet activation has be
@ @ @ @ @ @ @ @ @ @ @ @ @
en compromised. @
c. If the temperature was 1°C to 6°C and the platelet swirl seemed OK, it would be OK to
@ @ @ @ @ @ @ @ @ @ @ @ @ @ @ @ @
This@study@source@was@downloaded@by@100000826342158@@on@09-15-2021@17:54:15@GMT@-
05:00
https://www.coursehero.com/file/25537437/ch01rtf/
,https://www.stuvia.com/
accept the unit into inventory.
@ @ @ @
d. If the platelets appeared OK and passed the platelet swirl test after being placed on
@ @ @ @ @ @ @ @ @ @ @ @ @ @ @
the agitator, they could be accepted into the inventory.
@ @ @ @ @ @ @ @
@ 20. Which metabolic pathway permits the accumulation of 2,3 diphosphoglycerate (2,3-DPG)?
@ @ @ @ @ @ @ @ @ @
a. Glycolysis c. Pentose phosphate shunt @ @
b. Luebering-Rapoport shunt d. Methemoglobin reductase @ @ @
@ 21. All of the following are consistent with a "shift to the right" of the hemoglobin-oxygen dissociation curve
@ @ @ @ @ @ @ @ @ @ @ @ @ @ @ @ @
except:
a. Increased 2,3-DPG. @
b. 50% O2 saturation to tissues.
@ @ @ @
c. Decreased 2,3-DPG. @
d. Decreased hemoglobin affinity for O2. @ @ @ @
@ 22. What is the normal platelet count range per cubic millimeter?
@ @ @ @ @ @ @ @ @ @
a. 100 to 350 @ @ c. 50,000 to 200,000 @ @
b. 150,000 to 350,000 @ d. 350,000 to 500,000
@ @ @ @
@ 23. What cryoprotective agent is added to red blood cells upon freezing?
@ @ @ @ @ @ @ @ @ @ @
a. Dextrose c. Glycerol
b. Adsol d. All of the above @ @ @ @
@ 24. If platelets are to be stored for 5 days on a rotator, what is the optimal storage temperature?
@ @ @ @ @ @ @ @ @ @ @ @ @ @ @ @ @ @
a. 1°C to 6°C @ @ c. 35°C to 37°C @ @
b. 20°C to 24°C @ @ d. 1°C to 10°C @ @ @
@ 25. What role do platelets play in hemostasis?
@ @ @ @ @ @ @
a. Maintenance of vascular integrity @ @ @
b. Initial arrest of bleeding by platelet plug formation
@ @ @ @ @ @ @
c. Stabilization of the hemostatic plug @ @ @ @
d. All of the above @ @ @
@ 26. Which of the following best describes "integral" membrane proteins?
@ @ @ @ @ @ @ @ @
a. Reside at the cytoplasmic surface of membrane
@ @ @ @ @ @
b. Span the entire membrane surface
@ @ @ @
c. Form the red blood cell cytoskeleton
@ @ @ @ @
d. None of the above @ @ @
@ 27. How is stroma-free hemoglobin solution prepared?
@ @ @ @ @ @
a. Outdated red blood cells are concentrated, and stroma is removed.
@ @ @ @ @ @ @ @ @
b. Outdated red blood cells are diluted with saline, and stroma is removed.
@ @ @ @ @ @ @ @ @ @ @
c. Outdated red blood cells are lysed, and stroma is removed.
@ @ @ @ @ @ @ @ @
d. None of the above @ @ @
@ 28. What is the normal life span of an RBC?
@ @ @ @ @ @ @ @ @
a. 100 days @ c. 120 hours @
b. 120 days @ d. 2 days
@ @
@ 29. Regarding loss of RBC membrane deformability, all of the following are true except:
@ @ @ @ @ @ @ @ @ @ @ @ @
a. Increase in ATP level. @ @ @
b. Decrease in ATP level. @ @ @
This@study@source@was@downloaded@by@100000826342158@@on@09-15-2021@17:54:15@GMT@-
05:00
https://www.coursehero.com/file/25537437/ch01rtf/
This@study@source@was@downloaded@by@100000826342158@@on@09-15-2021@17:54:15@GMT@-
05:00
https://www.coursehero.com/file/25537437/ch01rtf/
,https://www.stuvia.com/
Chapter 1 RBCs and Platelet Preservation: Historical Perspectives and Current Trends
@ @ @ @ @ @ @ @ @ @
Multiple Choice
@
Identify the choice that best completes the statement or answers the question.
@ @ @ @ @ @ @ @ @ @ @
1. Which metabolic pathway is responsible for generating 90% of the ATP for the RBC?
@ @ @ @ @ @ @ @ @ @ @ @ @
a. Pentose phosphate shunt c. Glycolysis
@ @
b. Luebering-Rapoport shunt d. Methemoglobin reductase @ @ @
2. A unit of blood was returned to the blood bank before it was spiked. Apparently the patient’s IV failed.
@ @ @ @ @ @ @ @ @ @ @ @ @ @ @ @ @ @ @
The unit of blood was outside the blood bank for 35 minutes. Which of the statements below is most a
@ @ @ @ @ @ @ @ @ @ @ @ @ @ @ @ @ @ @
ccurate?
a. The unit of blood should be discarded immediately.
@ @ @ @ @ @ @
b. The unit of blood can be returned to inventory.
@ @ @ @ @ @ @ @
c. The unit of blood must be transfused within 4 hours or be discarded at the end of that time.
@ @ @ @ @ @ @ @ @ @ @ @ @ @ @ @ @ @
d. The unit of blood must be transfused with 24 hours.
@ @ @ @ @ @ @ @ @
3. What is the average diameter of a platelet?
@ @ @ @ @ @ @
a. 5 to 10 µm @ @ @ c. 1 to 2 µm @ @ @
b. 2 to 4 µm @ @ @ d. 4 to 6 µm
@ @ @ @ @
4. In the normal hemoglobin-
@ @ @
oxygen dissociation curve, what percentage of oxygen is released to the tissues when PO2 averages 4
@ @ @ @ @ @ @ @ @ @ @ @ @ @ @
0 mm Hg? @ @
a. 75% c. 100%
b. 25% d. 50% @
5. What factors are known to influence platelet metabolism and function?
@ @ @ @ @ @ @ @ @
a. Storage temperature c. Platelet count
@ @
b. Initial pH d. All of the above
@ @ @ @ @
6. Which of the following red blood cell morphologies may be present on the peripheral blood smear as a re
@ @ @ @ @ @ @ @ @ @ @ @ @ @ @ @ @ @
sult of loss of RBC membrane?
@ @ @ @ @
a. Spherocytes c. Burr cells @
b. Target cells d. Schistocytes
@ @
7. What does the term autologous transfusion refer to?
@ @ @ @ @ @ @
a. A parent donating blood for his or her child
@ @ @ @ @ @ @ @
b. An individual donating blood for a friend
@ @ @ @ @ @
c. An individual donating blood for a relative
@ @ @ @ @ @
d. An individual donating blood for his or her own transfusion
@ @ @ @ @ @ @ @ @
8. What is the primary function of hemoglobin?
@ @ @ @ @ @
a. Iron metabolism @ c. Oxygen transport @
b. Porphyrin synthesis d. Signal transduction
@ @ @
9. All of the following areas of red blood cell biology are crucial for normal erythrocyte survival except:
@ @ @ @ @ @ @ @ @ @ @ @ @ @ @ @
a. Cellular metabolism. c. Site of the ABO antigen attachment.
@ @ @ @ @ @
b. RBC membrane. @ d. Hemoglobin structure. @ @
This@study@source@was@downloaded@by@100000826342158@@on@09-15-2021@17:54:15@GMT@-
05:00
https://www.coursehero.com/file/25537437/ch01rtf/
,https://www.stuvia.com/
@ 10. What is the correct biochemical composition of the RBC membrane?
@ @ @ @ @ @ @ @ @ @
a. 52% protein, 40% lipid, 8% carbohydrate
@ @ @ @ @
b. 40% protein, 8% lipid, 52% carbohydrate
@ @ @ @ @
c. 8% protein, 52% lipid, 40% carbohydrate
@ @ @ @ @
d. 8% lipid, 40% carbohydrate, 52% protein
@ @ @ @ @
@ 11. All of the following biochemical changes are associated with loss of red blood cell viability upon storage
@ @ @ @ @ @ @ @ @ @ @ @ @ @ @ @ @
except:
a. Decreased pH. c. Increased ATP level.
@ @ @
b. Loss of red blood cell function.
@ @ d. Decreased glucose consumption.
@ @ @ @ @ @
@ 12. Which red blood cell preservative has a storage time of 35 days?
@ @ @ @ @ @ @ @ @ @ @ @
a. ACD c. AS-1
b. CPDA-1 d. CPD @ @
@ 13. The RBC membrane is relatively permeable to all of the following except:
@ @ @ @ @ @ @ @ @ @ @ @
a. Chloride. c. Bicarbonate.
b. Sodium. d. Water. @
@ 14. What percentage of platelets is sequestered in the spleen as functional reserve after being released from
@ @ @ @ @ @ @ @ @ @ @ @ @ @ @ @
the bone marrow?
@ @ @
a. 30% c. 10%
b. 50% d. 25% @ @
@ 15. What is the major biochemical consideration in platelet storage?
@ @ @ @ @ @ @ @ @
a. Glucose metabolism @ c. Production of carbon dioxide @ @ @
b. Oxygen supply @ d. Regulation of pH @ @ @
@ 16. What would the hemoglobin-
@ @ @ @
oxygen dissociation curve depict in a patient exhibiting clinical signs of alkalosis?
@ @ @ @ @ @ @ @ @ @ @
a. Normal c. Shift to the right @ @ @
b. Shift to the left @ @ d. None of the above
@ @ @ @ @
@ 17. Name the main lipid components of a red blood cell membrane.
@ @ @ @ @ @ @ @ @ @ @
a. Phospholipid c. Glycolipid
b. Sphingomyelin d. Glycophorin A @ @
@ 18. The ABO blood groups were discovered in 1901 by whom?
@ @ @ @ @ @ @ @ @ @
a. Charles Drew @c. Loutit and Mollison @ @
b. Karl Landsteiner @ d. Edward Lindeman @ @
@ 19. A standing order of platelets was shipped to your facility by your supplier. It was inadvertently left in th
@ @ @ @ @ @ @ @ @ @ @ @ @ @ @ @ @ @ @
e corner of the department until discovered 36 hours later. What would the appropriate action be for the
@ @ @ @ @ @ @ @ @ @ @ @ @ @ @ @ @ @
blood banker? @
a. If the temperature in the box was 22 +/-
@ @ @ @ @ @ @ @
2°C and the platelet swirl seemed OK, it would be OK to accept the unit into inventor
@ @ @ @ @ @ @ @ @ @ @ @ @ @ @ @ @
y.
b. The platelets have fallen outside the supplier’s quality assurance. The unit should be
@ @ @ @ @ @ @ @ @ @ @ @ @
discarded because the pH has probably dropped too low and platelet activation has be
@ @ @ @ @ @ @ @ @ @ @ @ @
en compromised. @
c. If the temperature was 1°C to 6°C and the platelet swirl seemed OK, it would be OK to
@ @ @ @ @ @ @ @ @ @ @ @ @ @ @ @ @
This@study@source@was@downloaded@by@100000826342158@@on@09-15-2021@17:54:15@GMT@-
05:00
https://www.coursehero.com/file/25537437/ch01rtf/
,https://www.stuvia.com/
accept the unit into inventory.
@ @ @ @
d. If the platelets appeared OK and passed the platelet swirl test after being placed on
@ @ @ @ @ @ @ @ @ @ @ @ @ @ @
the agitator, they could be accepted into the inventory.
@ @ @ @ @ @ @ @
@ 20. Which metabolic pathway permits the accumulation of 2,3 diphosphoglycerate (2,3-DPG)?
@ @ @ @ @ @ @ @ @ @
a. Glycolysis c. Pentose phosphate shunt @ @
b. Luebering-Rapoport shunt d. Methemoglobin reductase @ @ @
@ 21. All of the following are consistent with a "shift to the right" of the hemoglobin-oxygen dissociation curve
@ @ @ @ @ @ @ @ @ @ @ @ @ @ @ @ @
except:
a. Increased 2,3-DPG. @
b. 50% O2 saturation to tissues.
@ @ @ @
c. Decreased 2,3-DPG. @
d. Decreased hemoglobin affinity for O2. @ @ @ @
@ 22. What is the normal platelet count range per cubic millimeter?
@ @ @ @ @ @ @ @ @ @
a. 100 to 350 @ @ c. 50,000 to 200,000 @ @
b. 150,000 to 350,000 @ d. 350,000 to 500,000
@ @ @ @
@ 23. What cryoprotective agent is added to red blood cells upon freezing?
@ @ @ @ @ @ @ @ @ @ @
a. Dextrose c. Glycerol
b. Adsol d. All of the above @ @ @ @
@ 24. If platelets are to be stored for 5 days on a rotator, what is the optimal storage temperature?
@ @ @ @ @ @ @ @ @ @ @ @ @ @ @ @ @ @
a. 1°C to 6°C @ @ c. 35°C to 37°C @ @
b. 20°C to 24°C @ @ d. 1°C to 10°C @ @ @
@ 25. What role do platelets play in hemostasis?
@ @ @ @ @ @ @
a. Maintenance of vascular integrity @ @ @
b. Initial arrest of bleeding by platelet plug formation
@ @ @ @ @ @ @
c. Stabilization of the hemostatic plug @ @ @ @
d. All of the above @ @ @
@ 26. Which of the following best describes "integral" membrane proteins?
@ @ @ @ @ @ @ @ @
a. Reside at the cytoplasmic surface of membrane
@ @ @ @ @ @
b. Span the entire membrane surface
@ @ @ @
c. Form the red blood cell cytoskeleton
@ @ @ @ @
d. None of the above @ @ @
@ 27. How is stroma-free hemoglobin solution prepared?
@ @ @ @ @ @
a. Outdated red blood cells are concentrated, and stroma is removed.
@ @ @ @ @ @ @ @ @
b. Outdated red blood cells are diluted with saline, and stroma is removed.
@ @ @ @ @ @ @ @ @ @ @
c. Outdated red blood cells are lysed, and stroma is removed.
@ @ @ @ @ @ @ @ @
d. None of the above @ @ @
@ 28. What is the normal life span of an RBC?
@ @ @ @ @ @ @ @ @
a. 100 days @ c. 120 hours @
b. 120 days @ d. 2 days
@ @
@ 29. Regarding loss of RBC membrane deformability, all of the following are true except:
@ @ @ @ @ @ @ @ @ @ @ @ @
a. Increase in ATP level. @ @ @
b. Decrease in ATP level. @ @ @
This@study@source@was@downloaded@by@100000826342158@@on@09-15-2021@17:54:15@GMT@-
05:00
https://www.coursehero.com/file/25537437/ch01rtf/
